Prof. Antonio Almeida from Hospital da Luz in Lisbon takes us through his professional journey in hematology as a clinician and educator, and his current role as the President of EHA. Listen to prof. Almeida recount his professional path that allowed him to experience various facets of hematological clinical practice in the UK and Portugal.

Alongside his career as a hematologist, prof. Almeida cultivated a growing love for education, where he tries to employ student-centered techniques to enhance educational experiences.

Tune in to hear how prof. Almeida describes his journey to becoming the President of EHA and what he sees as today’s most significant challenges in hematology and what solutions he has in mind to address those.

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof. Antonio Almeida

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Join us for a conversation between prof. Kirsten Gronbaek and her guest prof. Dominik Wolf, as they discuss targeting the immune system in MDS management. In light of accumulating evidence that inflammatory signals play a role throughout disease evolution in MDS patients, prof. Wolf elucidates the current insights and possible future therapeutic options.

He uses the example of targeting NLRP3/IL-1 axis in low-risk MDS to highlight the need of understanding the underlying cellular biology to translate that knowledge into clinical approaches. He also discusses the concept of possibly targeting both non-clonal and clonal compartments for better patient outcomes in the future.

Tune in, to hear about other future directions in treatment of MDS, such as recent developments in CAR T-cell approaches and about the central role that allo-transplantation is likely to keep in the treatment of high-risk MDS. You will also hear about the potential link between inflammation and fatigue, which is clinically highly relevant, but as yet an unsolved issue in MDS.  

Host: prof. Kirsten Gronbaek

Guest: prof. Dominik Wolf

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Listen to Dr. Jan Moritz Middeke from University Hospital in Dresden as he discusses the future of clinical trials in hematology and the role artificial intelligence (AI) may play in that field. Dr. Middeke explains how synthetic data is generated and what are the potential benefits and limitations of its use in clinical trials. He also points out the open questions and hurdles that need to be addressed before AI-generated synthetic patients can be included in clinical trial design.

Tune in to hear how Dr. Middeke envisages the role of AI in solving the challenges of clinical trials for rare malignant diseases and how it may accelerate data generation and access to novel therapies.

If you want to know more:

https://www.nature.com/articles/s41746-024-01076-x 

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Dr. Jan Moritz Middeke

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In this episode, Dr. Onima Chowdhury, a hematologist from the University Hospital in Oxford, talks about the diagnostic workup of Myelodysplastic Syndromes (MDS). With a focus on both clinical practice and research, Dr. Chowdhury outlines the essential steps and tests required for diagnosing MDS, discusses the role of morphology, cytogenetics, and the significance of NGS panels in the diagnostic process.

The conversation also touches on the potential of artificial intelligence in diagnostics, the prognostic value of genetic mutations, and the importance of considering germline disorders in MDS. This episode is a must-listen for healthcare professionals seeking to deepen their understanding of MDS diagnostics.

Host: Prof Kirsten Grønbæk

Guest: Dr Onima Chowdhury

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Join us for this insightful interview with prof. Brian Huntly from the University of Cambridge who tells about his professional journey in hematology as a clinician, scientist and educator.

Listen to prof. Huntly discuss his important contributions to the field of leukemia stem cell biology in the context of current understanding of cell biological hierarchies and leukemia development.

Prof. Huntly also touches on the concepts of early interception and tumor-specific and tumor-nonspecific areas to personalized medicine. Tune in to hear how prof. Huntly combines his work in the fields of science and clinical medicine and what his recommendations are for younger colleagues, who are in the early stages of their careers. 

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof Brian Huntly

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In this podcast, Prof Dame Lesley Fallowfield and Prof Clemens Wendtner discuss patient mental health and communication in the context of Chronic Lymphocytic Leukemia (CLL) treatment. They explore the psychological impact of CLL and leukemia in general, the importance of patient communication, and the need for integrated mental health support. 

The conversation highlights the challenges of explaining complex medical concepts to patients and the role of resilience in both patients and physicians. They also address the challenges of managing patient anxiety and depression, the role of trust in the doctor-patient relationship, the importance of empathy, and the need for integrated psychological support services.

Guests:

Prof Dame Lesley Fallowfield

Prof Clemens Wendtner

Note: This podcast is based on content provided by BeiGene. It has been reviewed by EHA, which found it unbiased and aligned with EHA educational standards, as well as edited by EHA to create an effective educational experience.

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Join us for an insightful interview with patient advocates Miriam Santos Freire (sickle cell disease) and Loris Brunetta (beta-thalassemia major). Benefit from their experiences as they discuss with our host Isabel Olivera-Martinez the promises and challenges of gene therapy for these conditions.

Listen to their experiences of living with these genetic conditions while they highlight the disparities in treatment access between wealthy and low-income countries. Both view gene therapy as a breakthrough that has the potential to cure these diseases, but express caution regarding its current limitations and complications. Tune in for their valuable insights and recommendations for advancing SCD and thalassemia management.

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guests:

Miriam Santos Freire, Patient representative for EuroBloodNet

Patient Advocacy & Communication for Sickle Cell (Portugal & UK) at European Sickle Cell Federation (ESCF)

European Hematology Association (EHA)

ERN-EuroBloodNet

Associação Portuguesa de Pais de Doentes com Hemoglobinopatias (APPDH) – also a Board Member

Loris Brunetta

Board Member of Thalassaemia International Federation (TIF),

Vice-chair of EHA Patients’ Advocacy Committee (PAC),

Member of the Patients and Consumer Working Party (PCWP) at EMA,

EMA expert on ESEC,

Former member of Committee for Orphan Medicinal Products (COMP) at EMA,

ePAG at EuroBloodNet,

Coordinator of the Italian Associations Advocacy Council (IAAC)

President of Associazione Ligure Thalassemici (Italy).

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Join us for an interview with Prof Kostas Stamatopoulos, as he shares his personal journey as both a medical doctor and a researcher in hematology and understand how these two activities have always been profoundly linked in his drive to deliver impactful solutions for patients - even though years may pass between a discovery and a change for patients in clinical practice.

Prof Stamatopoulos describes here his work into stereotypy of B-cell receptor (BCR) immunoglobulin and how this phenomenon explains the existence of the same or highly similar subsets of BCR clones in unrelated patients with CLL. Our guest explains further how this knowledge is leading to the classification of CLL patients into subsets with specific pathologies and might help personalize the treatment.

Next to translational research, Prof Stamatopoulos is focusing on patient empowerment. In this podcast, he will explain how he strives to create a more participatory healthcare model, and how he aims to transform education and training for young clinicians and researchers. 

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof Kostas Stamatopoulos

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This podcast episode is derived from the MDS Algorithm on EHA Campus. Check out the MDS Algorithm, which is an expert based tool for healthcare providers, ensuring a structured and evidence-based approach to managing myelodysplastic syndromes.

In this episode, our host Prof Kirsten Grønbæk from University of Copenhagen, discusses the management of high-risk MDS with Prof Katharina Götze from Technical University of Munich and Prof Valeria Santini from University of Florence. The experts delve into the two classification systems for MDS, defined by the International Consensus Classification (ICC) and World Health Organization (WHO) in 2022.

They discuss the impact of the similarities and discrepancies between these systems on clinical practice and the patients’ understanding of their disease. The speakers further talk about hypomethylating agents (HMA) as the backbone of current treatments for high-risk MDS. They exchange their views on the considerations for choosing the patients who are most likely to benefit from these treatments, while avoiding myelotoxicity. The experts also discuss selecting the right patients for other (emerging) treatments, such as venetoclax and magrolimab, while stressing that data from phase III trials is yet to become available for some of these agents.

The role of allogeneic transplantation as the only curative option for patients with high-risk MDS is also emphasized, with the experts highlighting the role of Molecular International Prognostic Scoring System (IPSS-M) in selecting the eligible patients. In the closing remarks, the importance and challenges of monitoring the molecular evolution of the disease are stressed, as this technology allows to tailor the available treatments to each individual patient. 

Host: Prof Kirsten Grønbæk

Guests: Prof Katharina Götze & Prof Valeria Santini

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In this episode on recent insights about metabolism of the hematopoietic stem cells (HSCs), Dr Krzysztof Szade from Jagellonian University in Krakow, Poland, discusses HSPc in health, aging and malignancy. This podcast recaps the findings that aim to elucidate the metabolic requirements of HSCs at different stages of aging.

Listen to Dr Szade summarize the data on how heme oxygenase-1 (HO-1) influences glycolytic metabolic stemness of HSCs, impacting on their self-renewal and differentiation. Follow his explanations of the hierarchical relationship between myeloid-biased and balanced HSCs and other observations shedding more light on the mechanisms of HSC aging. As the understanding of the metabolic requirements of HSCs during aging can point to new therapies for hematological disorders, tune in for this latest update.

Guest: Dr Krzysztof Szade

This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify, YouTube, and EHA Campus. More lectures will be available in the future. Stay tuned!

For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/

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