Explore the latest breakthroughs in gene therapy for sickle cell disease and beta thalassemia with Dr. Stefano Rivella, hematologist and research faculty at Children's Hospital of Philadelphia.  

In this episode, Dr. Rivella discusses the science behind FDA-approved therapies, compares gene addition and gene editing approaches, and shares insights on clinical safety, efficacy, and future innovations like in vivo gene therapy.  

Learn about the challenges of access, cost, and global equity, and discover how evolving technologies could transform treatment for patients worldwide. 

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Dr Stefano Rivella

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Join us for this insightful interview with prof. Hartmut Döhner from University Hospital Ulm in Germany who tells about most recent developments in the management of older and unfit patients with AML.

Prof. Döhner discusses all key aspects of the management including assessing patient fitness, genetic risk classification, and the choice of treatment, among which also the emerging therapies.

Tune in, to hear about the most relevant recommendations for the clinical decision making while treating older unfit patients with AML.

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof Hartmut Döhner, University Hospital Ulm, Germany

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Join EHA President prof. Konstanze Döhner from University Hospital Ulm in Germany who discusses the most recent developments in the management of young and fit patients with AML. Tune in to hear about the diagnostic workup, risk stratification, treatment and the evolving role of measurable residual disease (MRD) measurements in clinical decision making in this group of patients. Prof. Döhner also shares her thoughts on the future of the treatment landscape for AML.  

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof Konstanze Döhner

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Listen as Prof. Christian Chabannon from Aix Marseille Université in France who tells about GoCART Coalition in this new podcast episode. The main goal of this coalition, which unites expertise from many fields, is to promote access to novel cellular therapies, such as CAR T-cells. Prof. Chabannon explain how GoCART is working on reaching this goal by generating new clinical insights, improving standards of care, providing education and building policy. Tune in to learn more about the impact of this coalition on healthcare today and in the future.     

Stay tuned for future episodes!   

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof. Christian Chabannon

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Jan Geissler from Germany tells about his work as a patient advocate in the field of hematological malignancies. As a cancer survivor, patient advocate and patient engagement expert, Jan has been working tirelessly for many years in organizations such as European Patients Academy (EUPATI), Patvocates and many others. Listen to Jan’s passionate call for a collaborative spirit to achieve the best outcomes for patients. Tune in to hear his views on patient advocacy and the impact it has on patient care.  

Stay tuned for future episodes!   

Guest: Jan Geissler, Patient Advocate, Germany 

Host: Isabel Olivera-Martinez, PhD, Medical Writer   

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Prof. Maria Themeli tells about most recent developments in the field of “off-the-shelf” CAR T-cells. As the clinical success of advanced cellular therapies is growing, so is the need for broader access to these treatments. Listen as Prof. Themeli summarize the state-of-the-art technology that aims to generate “off-the-shelf” CAR T-cells from sources such as induced pluripotent stem cells (iPSCs) and how this approach may offer a feasible strategy to improve clinical outcomes and reduce the costs of advanced cellular therapies in the future.   

Stay tuned for future episodes!   

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof Maria Themeli

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Join dr. Carmen Sanges from University Clinic Würzburg in Germany as she tells us about AIDPATH. This collaborative initiative is dedicated to improving access to advanced cellular therapies by employing artificial intelligence (AI) in the production process. Listen to dr. Sanges explain how AI technology is used to integrate patient-specific information and biomarkers to optimize CAR-T therapy. Tune in to hear about the current approaches and future directions of this cutting-edge technology. 

Stay tuned for future episodes!   

Host: Isabel Olivera-Martinez, Medical Writer 

Guest: Dr Carmen Sanges

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Join us for this inspiring interview with prof. Elizabeth Macintyre from Université Paris Cité in France who tells us about her professional journey in hematology.

Listen to prof. Macintyre discuss her views on the current state and future directions of advanced diagnostics in malignant hematology and their implications for healthcare management and the training of young specialists. Tune in to hear how Biomedical Alliance may impact future policies through “trans-European” approaches. 

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof Elizabeth Macintyre

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Join Professor Kirsten Gronbaek and Professor Uwe Platzbecker as they discuss the complexities behind the classification and prognostication of low-risk myelodysplastic syndromes (MDS). They dive into the historical context of MDS classification, the evolution of prognostic indexes such as IPSS and IPSSM, and the implications of recent molecular findings.  

This conversation highlights the challenges in defining "low-risk" MDS, the role of genetic mutations in prognosis, and the considerations for treatment strategies, including the potential for stem cell transplantation.  

Host: Professor Kirsten Gronbaek, University of Copenhagen, Denmark 

Guest: Professor Uwe Platzbecker, University Clinic of Leipzig

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Join host Professor Kirsten Gronbaek and guest Professor Arjan van de Loosdrecht as they dive into the complexities of measurable residual disease (MRD) monitoring in myelodysplastic syndromes (MDS) and myeloid cancers. Professor van de Loosdrecht explains the transition from minimal to measurable residual disease, the significance of MRD in predicting disease outcomes, and the various techniques used for MRD detection.  

Listen as they explore the challenges and potential strategies for MRD monitoring in MDS, and the implications for treatment decisions. This episode is a must-listen for anyone interested in the latest advancements in hematology and the future of MRD monitoring in MDS. 

Tune in to EHA Unplugged to gain valuable insights and stay updated with the latest research and clinical practices in hematology.

Host: Prof Kirsten Gronbaek

Guest: Prof Arjan van de Loosdrecht

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