Join dr. Carmen Sanges from University Clinic Würzburg in Germany as she tells us about AIDPATH. This collaborative initiative is dedicated to improving access to advanced cellular therapies by employing artificial intelligence (AI) in the production process. Listen to dr. Sanges explain how AI technology is used to integrate patient-specific information and biomarkers to optimize CAR-T therapy. Tune in to hear about the current approaches and future directions of this cutting-edge technology. 

Stay tuned for future episodes!   

Host: Isabel Olivera-Martinez, Medical Writer 

Guest: Dr Carmen Sanges

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Join us for this inspiring interview with prof. Elizabeth Macintyre from Université Paris Cité in France who tells us about her professional journey in hematology.

Listen to prof. Macintyre discuss her views on the current state and future directions of advanced diagnostics in malignant hematology and their implications for healthcare management and the training of young specialists. Tune in to hear how Biomedical Alliance may impact future policies through “trans-European” approaches. 

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof Elizabeth Macintyre

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Join Professor Kirsten Gronbaek and Professor Uwe Platzbecker as they discuss the complexities behind the classification and prognostication of low-risk myelodysplastic syndromes (MDS). They dive into the historical context of MDS classification, the evolution of prognostic indexes such as IPSS and IPSSM, and the implications of recent molecular findings.  

This conversation highlights the challenges in defining "low-risk" MDS, the role of genetic mutations in prognosis, and the considerations for treatment strategies, including the potential for stem cell transplantation.  

Host: Professor Kirsten Gronbaek, University of Copenhagen, Denmark 

Guest: Professor Uwe Platzbecker, University Clinic of Leipzig

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Join host Professor Kirsten Gronbaek and guest Professor Arjan van de Loosdrecht as they dive into the complexities of measurable residual disease (MRD) monitoring in myelodysplastic syndromes (MDS) and myeloid cancers. Professor van de Loosdrecht explains the transition from minimal to measurable residual disease, the significance of MRD in predicting disease outcomes, and the various techniques used for MRD detection.  

Listen as they explore the challenges and potential strategies for MRD monitoring in MDS, and the implications for treatment decisions. This episode is a must-listen for anyone interested in the latest advancements in hematology and the future of MRD monitoring in MDS. 

Tune in to EHA Unplugged to gain valuable insights and stay updated with the latest research and clinical practices in hematology.

Host: Prof Kirsten Gronbaek

Guest: Prof Arjan van de Loosdrecht

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In this episode, we sit down with prof. Martin Dreyling from the Ludwig-Maximilians-University in Munich who talks about his professional journey in hematology as a clinician and a researcher.

Listen to prof. Dreyling as he recalls his contributions to the field of lymphoma, and in particular mantle cell lymphoma, that resulted in novel therapeutic approaches. The ongoing emphasis on the cross-border teamwork in clinical trials and the importance of European cooperation highlights the impact that these initiatives had on prof. Dreyling’s career.

Tune in to hear his thoughts about the future directions in lymphoma treatment and collaborative clinical research in general.

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: prof. Martin Dreyling

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In this episode, prof. Kirsten Gronbaek and dr. Shahram Kordasti discuss the role of immune dysfunction in MDS. With the improving understanding of complex pathophysiology of MDS, the major role of the immune system in this process is becoming increasingly apparent.

Listen to dr. Kordasti discuss the multifactorial interactions between the malignant clones and the inflammatory environment, manifesting in elements of autoimmunity and elements of autoinflammation in MDS. As the complexity of immunophenotypes observed in MDS is being unraveled, the need to include immunophenotypic factors in the prognostic scores is growing.

Tune in to hear dr. Kordasti’s and prof. Gronbaek’s thoughts on the future of prognostication, the more comprehensive approach for patient stratification designed to predict therapy responses and the future of immunotherapy in MDS.

Host: Prof Kirsten Gronbaek

Guest: Dr Shahram Kordasti

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In this interview, dr. Maria del Mar Mañu Pereira from Vall d’Hebron Research Institute in Spain talks about the Rare Anemia Disorders European Epidemiological Platform (RADeep). RADeep is an initiative of ERN-EuroBloodNet and functions as an umbrella for both new and already existing European patients' registries in rare anemia disorders.  

Listen to dr. Mañu Pereira talk about the history of RADeep from its early days until today and about its ambitious goals to advance research and promote best practices in care for RAD patients across Europe. You will hear about the milestones achieved, current research, and how RADeep registry and the ENROL (European Rare Blood Disorders Platform) initiative complement each other to achieve optimal health outcomes for RAD patients.

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Dr. Maria del Mar Mañu Pereira

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Prof. Antonio Almeida from Hospital da Luz in Lisbon takes us through his professional journey in hematology as a clinician and educator, and his current role as the President of EHA. Listen to prof. Almeida recount his professional path that allowed him to experience various facets of hematological clinical practice in the UK and Portugal.

Alongside his career as a hematologist, prof. Almeida cultivated a growing love for education, where he tries to employ student-centered techniques to enhance educational experiences.

Tune in to hear how prof. Almeida describes his journey to becoming the President of EHA and what he sees as today’s most significant challenges in hematology and what solutions he has in mind to address those.

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Prof. Antonio Almeida

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Join us for a conversation between prof. Kirsten Gronbaek and her guest prof. Dominik Wolf, as they discuss targeting the immune system in MDS management. In light of accumulating evidence that inflammatory signals play a role throughout disease evolution in MDS patients, prof. Wolf elucidates the current insights and possible future therapeutic options.

He uses the example of targeting NLRP3/IL-1 axis in low-risk MDS to highlight the need of understanding the underlying cellular biology to translate that knowledge into clinical approaches. He also discusses the concept of possibly targeting both non-clonal and clonal compartments for better patient outcomes in the future.

Tune in, to hear about other future directions in treatment of MDS, such as recent developments in CAR T-cell approaches and about the central role that allo-transplantation is likely to keep in the treatment of high-risk MDS. You will also hear about the potential link between inflammation and fatigue, which is clinically highly relevant, but as yet an unsolved issue in MDS.  

Host: prof. Kirsten Gronbaek

Guest: prof. Dominik Wolf

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Listen to Dr. Jan Moritz Middeke from University Hospital in Dresden as he discusses the future of clinical trials in hematology and the role artificial intelligence (AI) may play in that field. Dr. Middeke explains how synthetic data is generated and what are the potential benefits and limitations of its use in clinical trials. He also points out the open questions and hurdles that need to be addressed before AI-generated synthetic patients can be included in clinical trial design.

Tune in to hear how Dr. Middeke envisages the role of AI in solving the challenges of clinical trials for rare malignant diseases and how it may accelerate data generation and access to novel therapies.

If you want to know more:

https://www.nature.com/articles/s41746-024-01076-x 

Host: Isabel Olivera-Martinez, PhD, Medical Writer 

Guest: Dr. Jan Moritz Middeke

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