What’s in a name? What can you really tell from a label like “polycystic ovarian syndrome”? And how much of that is more misconception than truth? The answer, as it turns out, is the former. In this episode, we delve into the world of PCOS, a world that shows us how preconceived notions of health and disease, gender and sexuality can do far more harm than good. For many people with PCOS, this condition violates society’s expectations of how you should look, act, or feel. And the resulting stigma and shame deepens the silence that often surrounds PCOS and leads to inadequate treatment and medical gaslighting. But thanks to the work of some incredible advocates, that silence is slowly fading. Tune in to discover the many lessons that PCOS can teach us, if only we are willing to learn.

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This episode, we aren’t asking you to taste the rainbow, but we are scrutinizing the artificial dyes that give it its color. When you’re munching on brightly colored candies or dipping a french fry in purple ketchup, what exactly is it you’re tasting? In this episode, we take you through the story of food dyes, from their serendipitous discovery to their enthusiastic overuse, from much-needed regulation to controversial health findings. You’ve read the headlines, now get the full picture of artificial food dyes.

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From the earliest grunts and gestures to the complex sentences we use today to convey a multitude of concepts, language has evolved to become one of humanity’s most powerful tools. It allows us to connect, create, conspire, control, console, catch up, and so much more. How did we come to have this uniquely human trait? What anatomical changes or cultural developments were necessary for language to evolve? What differentiates language from communication? In this TPWKY book club episode, Professor Steven Mithen joins us to discuss his latest book The Language Puzzle: Piecing Together the Six-Million-Year Story of How Words Evolved. By combining scholarship across wide-ranging fields such as archaeology, genetics, anthropology, linguistics, neuroscience, and more, Professor Mithen presents a compelling story of the origins of language. If you’ve ever wondered how babies can go from babbling one day and talking in a torrent of words the next, or how an individual language changes with each generation, this is the episode and book for you.

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In last week’s episode, we traced the history of fluoridation (and the anti-fluoridation movement) to its roots in the early 20th century, but we left you wondering whether there’s anything to back up the health claims that anti-fluoridationists make. Today, we get deep into the weeds of the fluoride literature, explaining how this mineral works, the difference between topical and systemic fluoride, and whether fluoridation has been linked to any health issues. The details matter, and don’t you worry - we’ve got plenty of nitty gritty for you to feast on.

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Is it just us, or does it seem like every other week there’s a new headline about some state or town banning water fluoridation? As it turns out, this has been going on for decades, basically since fluoride was first introduced. Why are some people opposed to fluoride? Is there any basis to their fears? What does fluoride actually do? And how the heck did we find out about it? This week and next, we’re deep diving into our first dental discussion about this revolutionary mineral. In the first of these episodes, we explore the origins of fluoridation and the outcry against it - how did tuberculosis, a gold rush town, and a dentist with an insatiable curiosity set the stage for one of the greatest public health achievements of the 20th century? And why has there been pushback against it since its inception? Tune in to find out.

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For many of us, pelvic exams are a routine part of our healthcare. Of course, that doesn’t mean we don’t await them with some dread or anxiety; naturally, these exams evoke a wide range of emotions. But they are a cornerstone in gynecological preventative care - a relatively new one at that. In this TPWKY book club episode, we sit down with Dr. Wendy Kline, Historian of Medicine at Purdue University, to discuss her book Exposed: The Hidden History of the Pelvic Exam. Dr. Kline takes readers through various chapters in the story of this exam: its murky origins at the hands of J. Marion Sims, its stint as a psychological diagnostic tool used by some misogynistic doctors, and its reclamation by feminist physicians and activists who sought to connect with their own bodies. Tune in for a fascinating conversation that exposes all sides of the pelvic exam, with heroes, villains, and more.

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If you’ve ever read the little instructions pamphlet included in a box of tampons, you probably came across a paragraph calling attention to a condition called toxic shock syndrome (TSS). It describes the association between TSS and tampon use, symptoms of TSS, and guidance on how to reduce risk. This legally mandated warning label has formed an indelible link connecting tampons and TSS, and indeed, tampons form a large part of the story of TSS. But they are not the entire story. In this episode, we delve into that full story, examining what TSS actually is, the pathogens it’s associated with, and how it was first identified. If you’ve had TSS questions ever since you first heard of it in health class or on your box of tampons, this is the episode for you!

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This week, we’re coming at you with a classic TPWKY episode on one of the most notorious poisons out there: strychnine. Although strychnine might not flash across too many headlines these days, it was once imported by the ton in certain regions of the world. What did people want with so much strychnine? Depends on who you ask. Maybe it was for a revitalizing tonic, maybe a rat poison, or maybe it was to murder the founder of a famous university. Tune in to learn how this deadly poison acts on the body and keep listening for a very special musical treat. 

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For the past few months, measles has been in regular rotation in the news cycle here in the US, with outbreaks occurring across the country in regions with low vaccine uptake. These outbreaks represent a worrying trend in the rejection of scientific and medical expertise, with long-term consequences not only for those individuals refusing vaccines but also the communities to which they belong. In this TPWKY book club episode (recorded March 14, 2025), Dr. Adam Ratner joins us to discuss his book Booster Shots: The Urgent Lessons of Measles and the Uncertain Future of Children's Health. With his firsthand experience treating children with measles and other vaccine-preventable diseases, Dr. Ratner provides a powerful perspective on the dangers of the measles virus and vaccine hesitancy. What can we learn from the history of measles and the measles vaccine rollout? Why is measles such a dangerous virus? Where do we go from here? Tune in for all this and more.

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Last week, we started this two-parter with a big picture view of pasteurization and the raw milk movement. In this episode, we address the alleged health claims made by proponents of raw milk and dive into the very real risks carried by its consumption. Is raw milk actually better for you? Does it have more vitamins or prevent allergies? What deadly pathogens does it harbor? How much does drinking raw milk increase your chance of contracting a milk-related disease? (Spoilers: A LOT). We tackle these questions with reliable data that paint a very different picture of raw milk than that shown by many raw milk influencers. Tune in for all this and more.

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