Chadi resumes his WCLC review with Dr. Eric Singhi of The University of Texas MD Anderson Cancer Center, exploring the most significant updates in mutation-driven lung cancer presented at this year’s meeting. The discussion dives into advances in sequencing and molecular profiling to identify actionable genomic alterations (AGAs) and how these findings are transforming both early- and late-stage treatment strategies. Dr. Singhi highlights key data from the ADAURA, TARGET, and NAUTIKA1 studies, as well as the expanding role of EGFR-, ALK-, BRAF-, and KRAS-targeted therapies in neoadjuvant and adjuvant settings. The conversation also examines the challenges of financial toxicity, decisions around adjuvant treatment cessation, and the nuanced management of locally advanced and stage IV EGFR-positive disease in the era of precision oncology.

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Dr. Estelamari Rodriguez, thoracic oncologist at the University of Miami’s Sylvester Comprehensive Cancer Center, joins the show to break down the latest advances in non-mutation driven and small cell lung cancer presented at the World Conference on Lung Cancer (WCLC) and how they translate into everyday clinical practice. She discusses pivotal studies including the ALCHEMIST trial exploring adjuvant therapy in ALK-fusion–positive early-stage lung cancer, PACIFIC-2 assessing concurrent immunotherapy and radiation, and the FLAURA2 and MARIPOSA trials redefining targeted approaches for advanced disease. The conversation also delves into next-generation drugs transforming outcomes in extensive-stage small cell lung cancer, updates in mesothelioma, and the expanding use of liquid biopsy—now a cornerstone for diagnosis, monitoring, and guiding precision therapy for all patients.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA 

Returning guest Dr. Amer Zeidan of Yale Medicine and Smilow Cancer Hospital joins to discuss how clinicians should approach low-risk Myelodysplastic Syndrome (MDS), which is most often managed in community settings. He breaks down how to risk-stratify patients using molecular and prognostic markers, when to treat versus observe, and his preferred first-line therapies in today’s landscape. Dr. Zeidan also delves into the COMMANDS trial and the role of luspatercept, emerging questions shaping the future of low-risk MDS management, and offers a preview of high-risk MDS developments, including insights from the VERONA study.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Returning guest Jill Feldman, a prominent lung cancer survivor and patient advocate, shares her reflections on the World Conference on Lung Cancer (WCLC) from a patient’s point of view. She discusses how patients and advocates interpret complex scientific data, why attending conferences like WCLC is vital for bridging the gap between research and real-world experience, and how the dialogue between scientists and patients continues to evolve. Jill also highlights key takeaways from the meeting, including the growing focus on survivorship and the need for a more patient-centered lexicon when communicating about side effects and treatment outcomes.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA 

Investigative journalist and New York Times bestselling author Gardiner Harris joins the podcast to dive deep into his groundbreaking book, “No More Tears: The Dark Secrets of Johnson & Johnson.” Harris recounts the extensive research and challenges behind uncovering how J&J—long regarded as a trusted “goliath” of American healthcare—played a far greater role in fueling the opioid epidemic than Purdue Pharma, a contribution he argues led to more than two million American deaths yet received a fraction of the public scrutiny. He discusses the pushback he faced while exposing the company’s practices, critiques how the FDA failed to act more decisively, and examines the intersection of profit, policy, and patient safety. The conversation also touches on the modern science and marketing of Tylenol, revealing how deep the influence of corporate power runs in shaping public health narratives.

View more about the book.
https://gardinerharris.com/

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

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Returning guest Anthony DiGiorgio, DO, a practicing neurosurgeon at UCSF and noted health policy commentator, takes a deep dive into the 340B Drug Pricing Program—one of the most consequential yet misunderstood mechanisms in US healthcare. He traces the program’s origins in the early 1990s, designed to help safety net hospitals stretch scarce federal resources to better serve vulnerable patients. Dr. DiGiorgio examines how, over time, many institutions have leveraged 340B as an ancillary revenue stream rather than a patient-centered support system, detailing when and how these practices emerged, the financial incentives at play, and the consequences for both physicians and patients. He also discusses current policy debates and potential reforms aimed at restoring 340B to its original mission.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA 

Dr. Anand Patel, DO, founder of LV8 Health, walks us through the philosophy and mechanics of concierge-style longevity medicine. He explains how LV8 applies Medicine 3.0, combining precision diagnostics (DEXA, VO₂ max, resting metabolic rate, advanced blood panels) with regenerative and geroprotective therapies, nutrition, fitness, and sleep optimization. You’ll hear how he translates data from wearables and diagnostics into bespoke plans, how he helps patients sustain behavior change, and how he answers critics who question the scientific basis of his approach.

View the LV8 website.
https://www.lv8.health/

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Gavin MacBeath, CEO of TScan Therapeutics, takes us inside his journey from scientist to biotech leader and what it means to build and run a therapeutic development company at the cutting edge of immuno-oncology. He breaks down how TScan’s platform works to discover and match T-cell receptors (TCRs) with their antigens, and why TCR-T therapies may provide distinct benefits over CAR-T approaches, especially when tackling solid tumors. He also discusses which diseases are most likely to respond to TCR therapies and shares the latest updates on TScan’s clinical programs, from early-phase trials to an upcoming phase III study poised to shape the future of cancer treatment.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ 

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA 

Dr. Sameer Keole, radiation oncologist at Mayo Clinic Arizona and president of ASTRO, joins the show to preview the upcoming ASTRO Annual Meeting and its key themes. He reflects on his presidential term, discussing accomplishments, lessons learned, and initiatives like his “defense to offense” vision and community outreach efforts. Dr. Keole also tackles hot-button topics in radiation oncology, including the evolving roles of proton therapy and artificial intelligence in patient care.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA