Donald Trump’s polling has continued to edge down week after week. And yet approval of the Democratic Party is still stuck near its all-time low, according to Gallup and other surveys.

One interpretation of these polls is that the deep unpopularity of the party is an albatross around the neck of Democratic candidates. But there’s another interpretation that I think is more interesting—and perhaps more true. The fact that the party has no clearly defined national leader, and no clearly defined “brand” (sorry), is an opportunity for young Democrats to define themselves as individuals. Rather than act like a congregation all singing from the same hymnal, they can experiment, disagree, and adapt their message to their electorate. And that might ultimately prove to be a strength of the party heading into the 2026 midterms rather than a weakness.

Senator Ruben Gallego (D-Arizona) joins the show to talk about the Iran war, immigration, affordability vs. aspiration, and the future of the Democratic Party.

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If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson
Guest: Ruben Gallego
Producer: Devon Baroldi

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Dramatic regime change. Moderate regime evolution. A calamitous regional conflict. Or … no change at all. Today we consider how the Iran conflict might evolve following the killing of Supreme Leader Khamenei with Karim Sadjadpour, an American policy analyst at the Carnegie Endowment for International Peace.

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If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson
Guest: Karim Sadjadpour
Producer: Devon Baroldi

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The modern world swims in numbers: work metrics, fitness metrics, health metrics, social media metrics. Sometimes the quantification of life can make things better. But very often, I think they force us to play the games we can measure rather than the games we value. The quantified life has become a modern religion: a system of values that takes us over and keeps us from living the life we want.

Today’s guest is the philosopher C. Thi Nguyen. He is the author of the book The Score: How to Stop Playing Somebody Else's Game. We talk about metrics, the games of life, and how to listen to the parts of ourselves that cannot be reduced to numbers.

Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson

If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson

Guest: C. Thi Nguyen

Producer: Devon Baroldi

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The GLP-1 drug revolution has taken the medicine world by storm. I’ve done several episodes on the science of GLP-1s. But we’ve never done an episode like this before, where we talk to one of the most important people in charge of guiding the GLP-1 drug revolution.

Our guest is Dave Ricks, the CEO of Eli Lilly, the largest pharmaceutical company in the world. First we talk about what makes the GLP-1 drug category special and the science that Lilly is doing to improve these drugs. Then, we talk about the pharmaceutical industry more broadly. How it works. How it could work better. And I don’t shy away from the question that I think Pharma CEOs need to take much more seriously: If the pharmaceutical industry is theoretically more devoted than any other economic category to saving people’s lives, why do Americans distrust it more than any other industry in the entire economy?

Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson

If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson
Guest: David Ricks
Producer: Devon Baroldi

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Donald Trump suffered a huge blow Friday when the Supreme Court struck down the centerpiece of his economic policy: his vast system of tariffs. So, what happens now? Harvard’s Jason Furman explains the implications for the U.S. economy, consumers, global trade, and Trump’s strategy of centralizing power in the executive branch and using trade policy as a means of wringing concessions out of other counties.

Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson

If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson
Guest: Jason Furman
Producer: Devon Baroldi

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In the mid-20th century, a group of media and communications scholars proposed that the shift from spoken to written language—from orality to literacy—transformed our politics, our media, our social relations, and even our sense of consciousness. Today we’re undergoing another shift: from a literate culture to something stranger—a post-literate world awash in social media and digital communications in which oral traditions are making a comeback. Bloomberg’s Joe Weisenthal, the cohost of the Odd Lots podcast, has called this one of the most important trends in the world. Today he explains how he got hooked on orality theory and why it’s the skeleton key that unlocks so many oddities of the modern world.

Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson

If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson

Guest: Joe Weisenthal

Producer: Devon Baroldi

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In his epic cover story for The Atlantic this month, staff writer Josh Tyrangiel spoke to dozens of economists, workers, tech CEOs, and AI experts about the danger that artificial intelligence might pose to the labor force. Is AI developing the capacity to automate and even replace millions of white-collar jobs, as many technologists and some economists predict? Or is this a normal technology that, like previous generations of technology, will have a much slower effect on the workforce? We cover several scenarios before asking: Why does it seem like nobody in politics is paying close enough attention to this story?

Links: https://www.theatlantic.com/magazine/2026/03/ai-economy-labor-market-transformation/685731/

Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson

If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson

Guest: Josh Tyrangiel

Producer: Devon Baroldi

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Hello! I’m back from paternity leave just in time to talk about the biggest media earthquake of the year (so far): the Washington Post meltdown. For decades, the Post was a journalistic gem with superior coverage of politics. Last week, billionaire owner Jeff Bezos decided to gut roughly a third of the staff after the paper lost hundreds of millions of dollars in the last few years.

Today’s guest is Jim VandeHei, the cofounder of Politico and Axios and a former Post reporter. We talk about the decades-long rise and fall of the Post before zooming out to talk about the most important changes in news media over the past 20 years, the secret of 21st-century media success, and the coming storm of AI.

To read more about Derek’s opening comments on how the future of the news industry is going back to past, check out his Atlantic article on the subject here: https://www.theatlantic.com/ideas/archive/2018/12/post-advertising-future-media/578917/

Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson

If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson

Guest: Jim VandeHei

Producer: Devon Baroldi

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Throughout December and January, we’ve been re-airing some of our favorite episodes of the past year and beyond, and today's episode marks the end of our "best of" series for this year! This list includes interviews that really stuck with me and some others that you guys had tons of feedback and thoughts on … including this one!
“What’s the Matter With America’s Food?” originally aired September 26, 2025.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guests: Julia Belluz and Kevin Hall
Producer: Devon Baroldi

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Throughout December and January, we’re going to be re-airing some of our favorite episodes of the past year and beyond. This list includes interviews that really stuck with me and some others that you guys had tons of feedback and thoughts on … including this one!

“This Is How the AI Bubble Could Burst” originally aired September 23, 2025.

If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson
Guest: Paul Kedrosky
Producer: Devon Baroldi

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