Chadi sits down with Ezra Cohen, MD, Chief Medical Officer of Oncology at Tempus AI, for an in-depth discussion on the evolving role of next-generation sequencing (NGS) across the cancer continuum. Together, they explore how tissue-based testing, liquid biopsy, and measurable residual disease (MRD) assessments are reshaping precision oncology, why NGS remains underutilized in many patients, and the educational efforts needed to ensure genomic testing is ordered and applied appropriately to improve outcomes. Dr. Cohen also examines the growing role of artificial intelligence in interpreting and integrating genomic data, including Tempus' embedded AI tools designed to support both clinicians and patients.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Healthcare Unfiltered Podcast and FASE 3 Podcast are collaborating on a new venture called "Hematology Sin Filtros" - a new podcast in Spanish that will be broadcasted once a month discussing various topics in hematology and cancer. Please share with your friends, colleagues and subscribe and join the conversation.

Los podcasts *Healthcare Unfiltered* y *FASE 3* colaboran en una nueva iniciativa llamada "Hematology Sin Filtros": un nuevo podcast en español que se emitirá una vez al mes para abordar diversos temas de hematología y oncología.
Por favor, compártelo con tus amigos y colegas, suscríbete y únete a la conversación.

In this deeply personal episode, Gabby shares her extraordinary journey of being diagnosed with stage IV metastatic colorectal cancer with liver involvement during the final stages of her pregnancy. She discusses the emotions and decisions surrounding her diagnosis, what she looked for when choosing her oncology team, how openly she communicated with her husband and young children, and the realities of navigating cancer treatment while welcoming a new baby. Gabby also reflects on documenting her experience in real time on social media, exploring both the support and challenges that come with sharing such an intimate journey publicly, while offering insight into the many clinical and personal decisions she has faced along the way.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Maen Abdelrahim, MD, PhD, Section Chief of Gastrointestinal Medical Oncology at Houston Methodist Neal Cancer Center—home to the nation’s highest-volume liver transplant program—joins the show to discuss the expanding field of transplant oncology, including which patients with hepatocellular carcinoma, colorectal cancer metastatic to the liver, biliary cancers, and intrahepatic cholangiocarcinoma may benefit from liver transplantation. He explores the history of liver transplantation and the development of the Milan criteria, how those advances paved the way for transplant oncology as a multidisciplinary specialty, and the ongoing educational gaps surrounding transplant eligibility and referral. Dr. Abdelrahim also shares insights from his book, “Transplant Oncology: A Frontier in Multidisciplinary Cancer Care,” while discussing the evolving role and safety of immunotherapy and ctDNA in the peri-transplant setting and the future of cancer care for patients once considered untreatable.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi hosts Dr. Chandana Banerjee of City of Hope and Kevin Diaz, CEO and President of Compassion & Choices, for a thoughtful conversation about Medical Aid in Dying (MAID) – what it is, who qualifies, how the process works, and why it remains one of the most debated issues in modern healthcare. Together, they explore the legal, ethical, and cultural complexities surrounding MAID, including the differences between MAID, assisted suicide, and euthanasia, the role of physicians and hospice care, the history and legal challenges of MAID legislation in the US, and the deeply personal realities patients and families face when navigating terminal illness, especially when loved ones disagree about care goals or when palliative and hospice care are no longer enough.

Read more about Compassion and Choices.
https://compassionandchoices.org/

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with Dr. Daniel Olson to discuss the growing excitement surrounding tumor-infiltrating lymphocyte (TIL) therapy in melanoma, including how these personalized cellular therapies are created (and sometimes engineered in the lab), the logistical challenges of collection and reinfusion, and the clinical data that led to FDA approval based on a single-arm study. Dr. Olson also explores treatment sequencing with immunotherapy and targeted therapy, the severity and duration of associated toxicities, response rates seen in practice, and the expanding potential for TIL therapy in other malignancies such as lung and cervical cancers, offering a practical and forward-looking look at one of the most promising advances in solid tumor oncology.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by Dr. Sewanti Limaye to discuss what precision oncology looks like in India, exploring the realities of access, affordability, infrastructure, and innovation in cancer care. Drawing on her experience training and practicing in the United States before returning to Mumbai to lead oncology and translational research programs, Dr. Limaye explains which genomic tests, liquid biopsies, and targeted therapies are currently available in India, the challenges surrounding out-of-pocket costs and insurance coverage, and why helping even a small percentage of patients access precision medicine can have a major impact. The conversation also covers clinical trial capabilities, lab turnaround times, international players in the liquid biopsy space, and the complexities of FDA-approved drugs that remain unavailable for prescription in India.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with sit down with Sue S. Yom, MD, PhD, FASTRO—radiation oncologist at UCSF, Editor-in-Chief of the International Journal of Radiation Oncology Biology Physics, and leader within NRG Oncology—to explore the critical role of cooperative groups in advancing cancer research. She unpacks their history, the benefits and challenges of large-scale collaboration, and how federal funding and partnerships with industry shape the design and execution of clinical trials. Dr. Yom also shares insights from her editorial perspective and highlights what’s ahead in radiation oncology, including the growing role of biomarkers, personalized treatment strategies, and smarter sequencing of therapies.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Gary L. Simmons, DO, MSHA—physician and entrepreneur in a Virginia community practice—dives into the rapidly evolving world of cell and gene therapy (CGT), including bone marrow transplant, CAR-T, and TILs, and what it takes to bring these cutting-edge treatments safely into the community setting. He unpacks the operational, financial, and workforce challenges of building and scaling a CGT program outside of academia, from payer hesitancy and 340B pressures to the infrastructure and staffing required for success. The conversation also explores the future of CGT, how innovation may reshape access, and why community practices could play a critical role as demand outpaces traditional academic centers.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Returning guest Dr. Tom Beer, Chief Medical Officer for Multicancer Early Detection (MCED) at Exact Sciences, joins the show to break down the promise and complexity of MCED testing—what it is, the clinical gap it aims to fill, and how it could reshape cancer diagnostics. He explores which patient populations may benefit most, the current limitations across different cancer types, and whether MCED tests are poised to complement or replace traditional single-cancer screening approaches. The conversation also tackles key nuances like balancing sensitivity and specificity, interpreting negative results, and how clinicians and patients should think about repeat testing in an evolving screening landscape.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA