Mind Melt Podcast; discussions in life, health, happiness and world news

#66 SE with Nate and Edidie

Edward Tracie 

Deep Discussions on youtube YT page https://www.youtube.com/channel/UCtftwuFFsiXLkzmpWPncd5wFacebookhttps://www.facebook.com/Deep-Discussions-1873660076235487/Nathan FergusonAbstract Activist Youtube 

https://www.youtube.com/channel/UCaGAzPm0iExb4I4iq0TCXEwWhat is SE?While definitions vary, it's generally accepted that Street Epistemology is a conversational tool that helps people reflect on the quality of their reasons and the reliability of their methods used to derive one's confidence level in their deeply-held beliefs.https://streetepistemology.com/Buckle up bitches 

Dive in with us and as always, please email with questions. [email protected]

Thank you so much for listening and please leave a review on Itunes / Stitcher 

Instagram = @mindmeltpodcast.

#65 Louis V. Tim B. Tyler T. Coronavirus, Economic collapse, Dow, Socialized healthcare ----more----

Buckle up bitches 

Dive in with us and as always, please email with questions. [email protected]

Thank you so much for listening and please leave a review on Itunes / Stitcher 

Instagram = @mindmeltpodcast.

Buckle up bitches 

Dive in with us and as always, please email with questions. [email protected]

Thank you so much for listening and please leave a review on Itunes / Stitcher 

Instagram = @mindmeltpodcast.

Professor Dave has a knack for explaining science stuff and he wants to share his knowledge with you. He received a BA in chemistry from Carleton College, and performed graduate studies in both synthetic organic chemistry and science education at Cal State Northridge, receiving an MA in the latter. Prior to this he taught for about a decade in various high school and undergraduate settings, specializing in organic chemistry but also teaching general chemistry, physics, and biology. His channel is certainly for students in science courses at both the high school and undergraduate level, but it is also for members of the general public that just want to know a little more about the world and how things work. His goal is to increase science literacy in our society so please share these tutorials with anyone that you think might enjoy them. Happy learning!

https://www.youtube.com/professordaveexplainshttps://www.instagram.com/daveexplains/https://twitter.com/daveexplains

Thank you so much for listening and please leave a review on Itunes / Stitcher 

Instagram = @mindmeltpodcast.

#62 Steve McRaeGraduate of Naval Nuclear Power School/Knoll's Atomic Power Laboratories. Steve's channel is the place where people can come bring their presentations and thoughts on science and philosophy to discuss that would be of interest in the Great Debate Community. Featuring prominent Phd's and experts to engage them in real time on various topics relating to refuting Young Earth Creationism and bad science in general. Please feel free to distribute my videos/hangouts on FB/Twitter or any other social media if you like others to get introduced to the Great Debate Community! Host/Owner - Great Debate Communityhttps://www.youtube.com/channel/UC1SzlwfeQ_4-9LuV_00Efuwhttps://twitter.com/stevemcraehttps://greatdebatecommunity.com/https://www.youtube.com/channel/UCgnIsA-D3PX6g6gi6Nyuewg

#61 Dr. Vincent A. Fischetti (Phage bacteria, antibiotic resistance, coronavirus) 

https://www.rockefeller.edu/our-scientists/heads-of-laboratories/1160-vincent-a-fischetti/

From the web:The Fischetti lab exploits the evolution of bacteria-killing viruses, known as phages, to develop new ways to prevent and treat bacterial infections. This strategy has revealed bacteria-killing enzymes and novel immunotherapies that can overcome antibiotic-resistant bacteria.

Fischetti works with both gram-positive and gram-negative bacteria, such as streptococci, staphylococci, anthrax, and acinetobacter, to develop unique treatment strategies to prevent infection. His approach involves novel immunotherapies and the use of phage lytic enzymes to both prevent infection and remove pathogenic bacteria from infected tissues.

Fischetti’s lab uses recombinantly produced phage lysins that will kill the major gram-positive and gram-negative pathogens including Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Clostridium difficile, Bacillus anthracis, and Acinetobacter baumannii. The enzymes are extremely potent; micrograms can destroy millions of organisms within seconds. They are also highly specific and, unlike antibiotics, only kill the disease-causing bacteria, without harming the beneficial bacteria.

Fischetti’s studies have shown that when small amounts of phage lysins are administered to infected mice, disease-causing bacteria are rapidly destroyed. In an animal model of pneumococcal pneumonia, Fischetti and his collaborators have shown that systemic administration of the phage enzyme Cpl-1 can rescue infected mice and completely reverse lung tissue damage if given within 24 hours post-infection. Similarly, experiments involving antibiotic-resistant S. aureus causing serious bacteremia in mice returned similar results after treatment with a staphylococcal-specific lysin. This lysin technology has been licensed and is currently in human clinical trials.

Using lytic enzymes as a tool, Fischetti’s lab developed a method of drilling through the thick cell walls of gram-positive bacteria while keeping the cells intact. The technique enabled the researchers to access the bacterial cytoplasm with labeled antibodies to study intracellular molecules that were previously inaccessible.

As a result of the high variability and plasticity of S. aureus, vaccine development has been challenging and has yet to be accomplished. Using the high-affinity binding domain of phage lysins directed to S. aureus, the Fischetti lab has successfully developed fusion immunoglobulins (called lysibodies) with the capacity to bind to the common cell wall of all Staphylococci, resulting in efficient phagocytic killing by human white blood cells. Lysibodies may be used to boost the immune response of Staphylococcus-infected patients.

Because bacteria use their surface molecules to attack and invade human tissues, a better understanding of how they anchor these molecules in their cell walls could lead to new strategies to prevent infection. The M surface protein is the major virulence factor of group A streptococci because of its ability to impede human white blood cells. Analysis by Fischetti’s lab shows that the region used to attach the M protein to the streptococcal cell surface is highly conserved in all gram-positive bacteria, indicating that the mechanism for anchoring surface proteins in bacteria is also conserved. Since bacteria cannot cause infection without surface proteins, a molecule that blocks surface protein attachment would be broadly applicable to different gram-positive bacteria.FOLLOW US:https://www.facebook.com/mindmeltpodcast/https://www.instagram.com/mindmeltpodcast/

#58 solorant #6 Louis V.

Feb 28th, 2020

 

#60 Solorant #7

Dive in with us and as always, please email with questions. [email protected]

Thank you so much for listening and please leave a review on Itunes / Stitcher 

Instagram = @mindmeltpodcast.

#59 DR. Alex RosenbergAlex is a huge inspiration to me because he says what everyone in the sciences knows, but is afraid to say. He has a way of public speaking that is truly captivating so I am very thankful for the chance to speak with him for the short time i did. If you enjoy this comnversation please check out more from him and BUY HIS BOOKS. Links below: 

From his website:Alex Rosenberg is the R. Taylor Cole Professor of Philosophy at Duke University (with secondary appointments in the biology and political science departments). Alex has been a visiting professor at many universities, including Oxford University and more recently the Philosophy Department at the Research School of Social Science of the Australian National University and the University of Bristol. He has held fellowships from the National Science Foundation, the American Council of Learned Societies, and the John Simon Guggenheim Foundation. In 1993 Alex received the Lakatos Award in the philosophy of science. In 2006-2007 he held a fellowship at the National Humanities Center. He was also the Phi Beta Kappa-Romanell Lecturer for 2006-2007. He's the author of more than a dozen academic books and a couple of hundred papers. Alex has also written two historical novels published by Lake Union. The Girl from Krakow appeared in 2015, and Autumn in Oxford, was published in August 2016.How history gets things wrong:https://www.amazon.com/How-History-Gets-Things-Wrong/The atheists guide to reality:https://www.amazon.com/Atheists-Guide-Reality-Enjoying-Illusions/dp/0393344118Subscribe rate and review

#58 Solorant #6

Dive in with us and as always, please email with questions. [email protected]

Thank you so much for listening and please leave a review on Itunes / Stitcher 

Instagram = @mindmeltpodcast.

#57 Dr. Darrel Ray! Darrel Wayne Ray is an organizational psychologist who focuses on various topics like workplace organizational culture and secular sexuality. He is also a speaker, podcaster and atheist activist. He helped found the organization Recovering from Religion.https://www.seculartherapy.org/dr-darrel-rayhttps://www.facebook.com/DrRayLifeCoachhttps://www.recoveringfromreligion.org/