This extensive document provides a comprehensive overview of the protocols and legal requirements for addressing missing and exploited persons, particularly within a law enforcement context. It outlines definitions for missing children and adults, establishing different categories of missing persons like involuntary, endangered, or those with disabilities. A significant portion of the text focuses on the role and functions of the Missing Children and Missing Persons Information Clearinghouse and mandatory law enforcement requirements, including immediate investigation and timely data entry into national systems like NCIC and NamUs. Furthermore, the source details various types of statewide alerts (e.g., AMBER, Silver, CLEAR) and mandates procedures for schools to flag records of missing children under the age of eleven. Finally, the text explores different types of exploitation and human trafficking, outlining signs for interdiction and providing best practices for a trauma-informed approach during victim recovery and reunification.