Mission Methuselah ft Terry and Jahan

Terry and Jahan discuss the benefits to saunas as well as explore the biology and side topics

07:00 DNA Methylation

10:30 Machine learning

12:30 Specifics of methylation

13:50 Possible future uses of DNA Methylation

15:00 Physical activity and clocks

16:47 DHEA, metformin and decreased Horvath clock

18:30 Commercialisation of science

20:25 BPAD and Lithium

23:50 Cell and organism link

25:10 US presidents and ageing

27:23 Metacognition

31:45 Alzheimers and sleep

33:45 Alzheimers and diabetes

37:00 Alcohol, cannabis and eating for sleep

38:44 Alcohol withdrawal and sleep

44:30 Personal genome mapping

45:30 Health insurance and genetics

53:50 Chinese social score

56:30 Insurance subsidies based on biological age

57:50 Public health approach to medicine

01:02:30 Importance of having a GP

Study links:

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13028

https://www.sciencedirect.com/science/article/abs/pii/S0149763419309935

While battling multiple fronts, including night shift brain and constant interruptions - Terry and Jahan defy the odds and manage to do a podcast on the job! While it may be a bit more fragmented than usual we manage to cover the interesting topics of sleep, nasal breathing, machine learning and automating biological assays.

Jahan and Terry tackle the mammoth topic of NAD+. What is it? Why is it important and what can we possibly due to boost the levels in the body?

In this next chapter, Terry and Jahan discuss some of the contradictory literature surrounding the mechanism of AKG, the challenges to doing this kind of science, and how not to study biochemistry.

Cellular Senescence happens when both the normal cell cycle is put on pause and there is failure of the cell to die. These zombie cells have been shown to be "problematic." We discuss the pros and cons of senescence and what we can do to mitigate their deleterious effects.

What is metformin? How does it help with longevity?

Terry and Jahan discuss the challenges, benefits, and research into fasting - especially time restricted feeding.