Epilepsy is the third most common neurological disorder in the United States, after Alzheimer’s disease and stroke. The condition affects nearly three million Americans, with some 200,000 new cases diagnosed each year. Half of all patients are children. Characterized by various kinds of seizures, epilepsy is a major chronic medical condition and can affect a person’s quality of life similar to arthritis, heart disease, diabetes or cancer. It can limit activity; cause pain, anxiety or depression; impede learning, behavior, and memory; and seriously affect development. Epilepsy may also present non-medical challenges such as discrimination and social stigma. This edition of Physician Focus examines the causes of epilepsy, how it’s diagnosed and treated, and the challenges it presents to patients, their families, and those around them.