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You have promising science. But is there actually a commercial opportunity behind it?
And if you’re considering moving from scientist to entrepreneur, how do you know whether your research has the ingredients for a biotech company?
Dr Laura Issa has spent years evaluating science through an industry and business development lens.
She is the founder of Bespoke Genetic Medicines and co-founder of Facio Biotech, with experience across pharma, biotech, research commercialisation and rare disease.
In this conversation, Laura gives us a practical framework for assessing the commercial potential of scientific research.
We start with what she looks for when academics pitch their research to industry. Good science alone isn’t enough.
Researchers need to understand what makes their approach meaningfully different, the competitive landscape, their intellectual property strategy and the evidence required to support their claims.
We also discuss when to seek industry feedback, why talking to patients, clinicians and payers early can change your research strategy, and when market research should begin. Spoiler: probably earlier than many scientists think.
Then we tackle the biotech spin-out question.
Laura shares five factors she considers when assessing whether academic research could become a viable biotech company, including unmet need, intellectual property, capital requirements, stage of development and the people needed to take it forward.
And importantly, starting a company isn’t automatically the answer. Sometimes licensing, partnering with industry or remaining in academia longer is the better development strategy.
We also explore why Laura remains optimistic about drug development in neurology despite its history of clinical failures, including the growing role of human-derived models, biomarkers, genomic and clinical datasets, and new approaches to generating evidence.
Finally, we move to a very different commercialisation problem: ultra-rare genetic disease.
Laura explains why conventional drug development economics can break down when a potential treatment may serve fewer than 100 people, and why these therapies may require completely different funding and development models.
In this episode:
This episode is Part 3 of a six-part series exploring the path from academic research to biotech and drug development, based on conversations from the 2026 Drug Discovery Forum in Sydney.
Across the series, scientists, biotech entrepreneurs, industry experts and technology transfer professionals unpack what it takes to move promising research beyond the lab and towards patients.
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
What happens when scientists stop presenting their research to other scientists and put it in front of biotech and drug development experts instead?
The questions change.
Suddenly it isn’t only, “Does the science work?”
It’s also: Who is the patient? What is the indication? What evidence do you need next? What could stop this programme? Who needs to partner with you? And what would a credible path to the clinic actually look like?
In this episode, Professor Greg Neely and Dr Jean Bertoldo share what happened when they pitched their research to industry experts at the 2026 Drug Discovery Forum ( ARCS conference 2026)
Their projects are at very different stages.
Prof Greg Neely is combining established biology and delivery technologies to explore new neurological applications.
Dr. Jean Bertoldo is working much earlier, building evidence around new biology in childhood brain cancer.
Both walked away with questions that changed how they thought about their drug development roadmap.
We also speak with Dr Gorjana Mitic about technology transfer and the role tech transfer professionals can play in helping scientists move promising academic research towards licensing, partnering or a biotech spin-out.
Gorjana takes us behind the scenes of a tech transfer office, including why promising projects can get stuck, what technology transfer teams actually assess, and what scientists can do to make their research easier to champion.
You’ll hear about:
This episode is Part 2 of a six-part series exploring the path from academic research to biotech and drug development, based on conversations from the 2026 Drug Discovery Forum in Sydney.
Across the series, we hear from scientists, biotech entrepreneurs, technology transfer professionals and industry experts about the decisions, evidence and people needed to give promising research its best chance of reaching patients.
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
Should your research become a medicine? And if it has commercial potential, should you be the scientist who takes it forward?
For academics considering the move from scientist to entrepreneur, that decision starts well before forming a biotech company.
In this episode, we explore how to assess academic research through a commercialisation and drug development lens. Professor Michael Kassiou, Dr Laura Issa and Dr Gorjana Mitic share what industry, investors and tech transfer teams look for when evaluating research with translational potential.
We discuss how an industry pitch differs from an academic presentation, when to seek industry feedback without compromising intellectual property, and the questions researchers need to answer around unmet need, differentiation, competitive landscape and IP.
We also look at a decision that is sometimes skipped entirely: does this research actually need a biotech spin-out?
Dr Laura Issa breaks down five factors to consider, including clinical need, intellectual property, capital requirements, stage of development and the people behind the project. We explore when staying within academia, licensing or partnering with industry may be a better route than starting a company.
You’ll hear about:
This episode is Part 1 of a six-part series exploring the path from academic research to biotech and drug development, based on conversations from the 2026 Drug Discovery Forum in Sydney, happening at the ARCS conference.
The series brings together scientists, biotech entrepreneurs, industry experts and technology transfer professionals to examine what it actually takes to move promising science towards patients.
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
A rapid-fire conversation on transferable STEM skills, working smarter, visibility and what is actually good enough to start.
What beliefs are quietly keeping STEM professionals stuck?
"I am just a scientist."
"I need to work harder."
"My work will speak for itself."
"I am not ready yet."
In this Fire Chat, Lauren Barber, nurse and founder of NeedleCalm, challenges some of the assumptions that can stop technical professionals from moving beyond the path they were trained for.
Lauren built a medtech company without starting with a business background. Her experience is a useful reminder that you do not need to know everything before you begin, but you do need enough energy and curiosity to keep taking the next right step.
🔍 What You'll Learn:
Play this episode if you have been waiting for more skills, more money, more confidence or a perfect plan before making your next move.
🧠 About the Guest:
Lauren Barber is a registered nurse and founder and CEO of NeedleCalm, an Australian medical device company focused on reducing pain and anxiety during needle procedures.
After repeatedly seeing the impact of needle fear in clinical practice, Lauren developed NeedleCalm and has spent the past decade learning how to turn clinical insight into a commercial product.
📌 Episode Highlights:
00:00 The beliefs that can keep STEM professionals stuck
01:20 Meet Lauren Barber and NeedleCalm
02:40 The clinical experience that led her towards entrepreneurship
04:15 "I'm just a scientist", why technical skills do transfer
05:10 Working smarter instead of simply working harder
06:00 Using AI as a thought and learning partner
07:00 When done is better than perfect
07:40 Why your work will not always speak for itself
08:20 What is actually good enough to start
08:50 Taking the next right step
🔗 Resources Mentioned:
🤔 Reflection Time:
Full interview:
🎧 https://shows.acast.com/multiple-hats/episodes/6a8114dbff328abd8407723c
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
How a nurse turned a recurring healthcare problem into NeedleCalm, and what ten years of building taught her about medtech entrepreneurship.
What happens when you keep seeing the same problem at work and decide to solve it yourself?
Lauren Barber spent years as a nurse watching patients struggle with needle fear, sometimes avoiding healthcare altogether. After a distressing procedure ended in a needle-stick injury for Lauren herself, she decided there had to be a better way.
That decision became NeedleCalm.
But the idea was the easy part.
Lauren had no business background and no commercialisation roadmap. Over the next ten years, she learned about patents, prototypes, grants, clinical trials, manufacturing, funding, procurement and one of the hardest parts of medtech, getting healthcare systems to adopt something new. fileciteturn0file0
🔍 What You'll Learn:
If you are a STEM professional sitting close to a problem you understand deeply, Lauren's story shows why that proximity can become a real entrepreneurial advantage.
You'll hear:
If you have ever looked at a problem in your lab, clinic or workplace and thought, "Someone should fix that", play this episode to see what taking the first step can actually look like.
🧠 About the Guest:
Lauren Barber is a registered nurse and founder and CEO of NeedleCalm, an Australian medical device company focused on reducing pain and anxiety during needle procedures.
She developed NeedleCalm after years of seeing the impact of needle fear on patients and has spent the past decade building the product while continuing to work clinically.
📌 Episode Highlights:
00:00 Why proximity to a problem can become an entrepreneurial advantage
03:20 What NeedleCalm is and why needle fear matters
07:15 The science behind the device
13:15 The needle-stick injury that changed everything
17:00 Starting with Google, a drawing and a provisional patent
21:30 Grants, prototypes and the first clinical trial
24:00 Learning the business side of medtech
28:30 R&D funding and manufacturing in Australia
30:00 Why product development is only half the challenge
33:00 Reimbursement, economics and healthcare adoption
38:15 The difficulty of scaling medtech in Australia
40:00 Ten years of sacrifice and founder burnout
42:00 What Lauren would do differently
43:00 Whose advice should you actually listen to?
45:00 Awards, self-nomination and running your own PR campaign
47:00 Why you do not need the whole plan before you start
🔗 Resources Mentioned:
🤔 Reflection Time:
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
What if feeling restless in a perfectly respectable STEM career does not mean you chose the wrong path, but that too much of you has been left outside it?
🔍 What You'll Learn:
STEM careers tend to reward the rational, analytical and credible parts of us. After years of training, those qualities can become our whole professional identity, while the writer, artist, teacher, founder or curious beginner quietly waits in the background.
This episode explores how to make room for more of yourself without resigning dramatically by Tuesday.
Play this episode to identify which part of you needs more room and choose one concrete action you can take this week.
🧠 About the Guests:
Dr Anupama Hariharan began her career as a dentist before moving into clinical research. Writing had been part of her life since childhood, but she placed it on the back burner while building a serious STEM career. Once she returned to it, she wrote six books in about a year.
Dr Sue Pillans is a marine scientist, artist, children's author and graphic recorder. Through Picture Your Ideas, she combines science, strategic thinking and visual storytelling to help people understand complex information.
Dr Chloe Lim has a PhD in medical science and works in regulatory science. After volunteering to make balloon animals at a community event, she discovered an unexpected creative skill and built Twisty Science, using balloon art to explain scientific concepts to children and families.
📌 Episode Highlights:
00:00 When a sensible STEM career becomes the only version of you
03:35 What it means to contain multitudes
05:15 The psychology behind our many selves
08:00 Psychosynthesis, Voice Dialogue and Dialogical Self Theory
11:50 Anu's story: returning to the writer who was always there
16:40 The conversation with her mother that brought writing back
18:45 Completing a 21-day poetry challenge in eight days
21:20 Sue's story: building a bridge between science and art
25:15 Discovering that graphic recording was a real profession
26:45 How visual storytelling makes complex science understandable
29:40 Chloe's story: discovering a new direction by trying something unexpected
31:55 Turning balloon art into Twisty Science
34:20 Why some parts of yourself can only be discovered through experimentation
35:25 Three patterns: revive, combine or discover
37:30 Why every interest does not need to become a business
39:05 Finding the part of yourself that needs more room
40:30 One concrete act of permission to take this week
🔗 Resources Mentioned:
🤔 Reflection Time:
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
A 10-minute Fire Chat on transferable STEM skills, perfectionism, working smarter and making space for creative work.
What if the biggest barrier to your next step is not a lack of time, money or skills, but the belief that you need more of all three before you can begin?
🔍 What You'll Learn:
Many STEM professionals assume their technical skills only matter inside their current field. Then they work longer, wait to feel ready and quietly hope their work will speak for itself. This episode challenges those assumptions.
Play this 10-minute episode to identify what is really holding you back and choose one practical step you can take this week.
🧠 About the Guest:
Dr Anupama Hariharan began her career as a dentist before moving into clinical research. Alongside her STEM career, she has become a published poet and fiction author.
In this Fire Chat, she explains how scientific discipline supports her creative work, why perfection is overrated and how completing an eight-day writing challenge gave her the confidence to publish her first book.
📌 Episode Highlights:
00:00 The beliefs that quietly hold scientists back
01:20 From dentistry and clinical research to becoming an author
01:45 The scientific skills that transfer beyond technical roles
02:20 What working smarter actually looks like
02:50 Why the book cover deserved focused attention
04:15 Is done really better than perfect?
05:00 What nature teaches us about beauty and imperfection
06:40 What is good enough to start?
07:40 Turning existing work into a practical first step
08:10 Completing a 21-day writing challenge in eight days
09:20 Facing rejection without giving away your creative voice
10:05 How science and creativity can strengthen each other
🔗 Resources Mentioned:
🤔 Reflection Time:
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
What if your scientific career and your creative life were never competing identities?
What if one could make the other stronger?
Dr. Anupama Hariharan has built a long career across dentistry and clinical research. She is also a published poet and fiction author.
For years, the writer in her stayed mostly in the background. Not because the talent was missing, but because the scientific path looked safer, more serious and easier to explain.
Once she gave that creative identity a real place in her life, everything shifted.
In this episode, you will learn:
Anu’s story is not about abandoning science to become an author.
It is about recognising that the scientist and the storyteller can exist in the same person.
Your creative side is not necessarily a distraction from your serious career. It may be the part of you that brings back energy, perspective and a stronger sense of self.
The question is not always, "Which identity should I choose?"
Sometimes the better question is, "Which part of me have I kept hidden because it did not look sensible enough on paper?"
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
What happens when “there has to be more than this” becomes the start of a completely different career.
🔍 What You’ll Learn:
Many STEM professionals assume career reinvention starts with a perfect plan, a business idea, or a dramatic leap.
The reality is usually much messier.
In this episode, Rachel Service shares how a period of burnout and depression eventually led her to build a multi-million dollar training business, despite having no business plan, no roadmap, and no idea what “corporate rates” even meant when she got her first client.
You’ll discover:
If you’ve been sitting on an idea, craving something more, or wondering whether you could build a different future, this episode will give you permission to start before you’re ready.
🧠 About the Guest:
Rachel Service is the founder and CEO of Happiness Concierge, a workplace training company that has worked with more than 200 organisations and trained thousands of employees and leaders. After experiencing burnout, anxiety, and depression, Rachel slowly rebuilt her life, eventually creating a business that allows her to work on her own terms while helping others create healthier workplaces.
📌 Episode Highlights:
00:00 The moment “there has to be more” becomes impossible to ignore
03:00 Burnout, depression, and crying through a Beyoncé concert
04:30 Why Rachel called her business Happiness Concierge
06:30 Starting without a master plan and following curiosity instead
07:30 The power of nurturing an alternative reality before taking action
08:30 How Rachel discovered she wanted to become a speaker
09:00 The first free talk that unexpectedly led to paid work
10:30 Building momentum through visibility and borrowing audiences
12:00 Why nobody is waiting to discover you
14:00 Working for free, building credibility, and finding your first customers
16:00 Different pathways to entrepreneurship depending on your risk profile
18:30 How to handle family members who don’t understand your ambitions
22:00 Why people struggle to imagine future versions of you
25:00 Rachel’s biggest business mistakes and lessons learned
27:00 The role of tiny experiments in career reinvention
🔗 Resources Mentioned:
🤔 Reflection Time:
One idea from Rachel that stayed with me:
“Show them because they can’t imagine.”
People cannot support, hire, promote, or buy from a version of you they’ve never seen before. Sometimes the next step isn’t becoming something new. It’s giving people evidence that you’re already becoming it.
This is ultimately an episode about permission. Permission to explore. Permission to test. Permission to imagine a different future before you know exactly how you’ll get there.
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
What if the biggest thing holding your career back isn’t a lack of skills, experience, or opportunity, but a belief you’ve been carrying for years?
🔍 What You’ll Learn:
Many STEM professionals underestimate the value of their skills, overestimate the need for perfection, and assume hard work alone will create opportunities.
In this quick-fire episode, Rachel Service tackles four common beliefs that keep scientists playing small and offers practical ways to think differently.
You’ll discover:
If you’ve ever thought “I’m just a scientist”, “I’m not ready”, or “I just need to work harder”, this episode will challenge those assumptions in under 10 minutes.
🧠 About the Guest:
Rachel Service is the founder and CEO of Happiness Concierge, a workplace training company that has worked with more than 200 organisations. Following her own experience with burnout and depression, Rachel built a business helping people improve communication, leadership, workplace culture, and career satisfaction.
📌 Episode Highlights:
00:00 The beliefs that quietly hold STEM professionals back
02:30 Rachel’s accidental entrepreneurship story and the burnout that started it all
03:15 “I’m just a scientist” and why that’s completely wrong
04:00 The scientific skills that transfer into almost any career
04:30 Does your work really speak for itself?
05:00 Why career growth eventually becomes a PR campaign
05:30 Done versus perfect, and the real fear underneath perfectionism
06:45 The question to ask when you think you don’t have enough time, money, or resources
🔗 Resources Mentioned:
🤔 Reflection Time:
One of my favourite insights from Rachel was this:
“It’s not about being perfect. It’s about learning to live with the idea that someone might see your incompetence.”
That’s uncomfortable. But it’s also where growth starts.
Want to craft a career story that opens doors?
I help STEMM professionals speak with clarity, confidence, and purpose and show up as thought leaders —so the right opportunities find you.
📬 Let’s connect: angeliquegreco.com.au | LinkedIn
⭐️ Help More People Reinvent Their Careers
If you enjoyed this episode, please:
Hosted on Acast. See acast.com/privacy for more information.
From the publisher's feed
Multiple Hats is a STEM career podcast for professionals who want more than the 9–5. Hear real stories of STEM professionals reinventing their careers — from scientists turned founders to…
Hosted by Angelique Greco, a biotech and health-tech expert with 15+ years across the drug development lifecycle, this show explores how STEM careers can evolve into entrepreneurship, thought leadership, and portfolio work that truly matters.
Through in-depth conversations with entrepreneurial STEM professionals, you’ll discover:
You will hear:
For who:
Scientists, PhDs, engineers, clinicians, biotech consultants, tech pros including women balancing STEM careers with motherhood while fighting stereotypes.
Why listen:
Representation and role modelling matter. Bold and brave STEM professionals share how they carved their own paths — so you can too.
🎙 New episodes weekly. Follow now to reinvent your STEM career and design work on your own terms.
STEMM = Science Technology Engineering Mathematics Medicine
Visit my website https://angeliquegreco.com.au/ for short bite insights and on how to start crafting your message to set you on track for the career your want.
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Hosted on Acast. See acast.com/privacy for more information.