We took this opportunity to discuss a few cases of period pain which impact the majority of women in their lifetime. Non-steroidal anti-inflammatory drugs (NSAIDs) are usually the first-line treatment for period pain and are effective. However, a proportion of women do not get much relief from them and in this episode, Esther and Fadhli explored why this might be the case. We dove into the genetic variations that exist in the metabolism of NSAIDs and how they can be analyzed through a pharmacogenomic test.

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In this episode, we spoke to Pak Johanes who benefited from taking genetic tests. Inspired by the idea of precision medicine he shared what made him interested in taking the tests and the variety of genetic tests that are available. He gained new insights about his health and how it can be implemented in his life. Pak Johanes talked about his excitement about the growing precision medicine scene in Indonesia.

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We sat down with the founder of Arcadia Clinic Jakarta, dr Alita, to chat about her experience with clinical genetics testing as well as her journey as a young doctor in Papua that started her interest in the field of personalized medicine.

dr Alita shared her philosophy in patient care, how she empowers her patients to be more confident in managing their own health, and how pharmacogenomics is used as a tool for this. She also explained the pros and cons of utilizing these tests in daily practice.

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Baitha Palanggatan Maggadani, M.Farm., Apt. is an experienced pharmaceutical and bioanalysis lecturer in Universitas Indonesia, that is currently conducting research together with Dr. Samuel Haryono, MRCCC, and Nalagenetics on pharmacogenomics.

In this episode, we dove deeply into the perspective of clinical pharmacogenomics implementation from the lens of a pharmacist and academician in Indonesia. Ms. Baitha expressed her hopes for genetics testing in Indonesia as well as elaborated the main challenges for its implementation.

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We are honored to be joined by Dr. dr. Samuel J. Haryono, Sp.B (K)Onk, a highly renowned surgical oncologist at Dharmais Cancer Hospital and Siloam MRCCC Hospital. He demonstrated his interest and excitement in implementing pharmacogenomic tests in breast cancer research and kindly shared new insights from his research in tamoxifen.

Dr. Samuel also elaborated his vision and hope that the research can be translated into wider clinical practice in optimizing breast cancer treatment.

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This sixth installment of NalaTalks introduces Nalagenetics' highly experienced clinical research associate and medical doctor, dr Amelia Margareta where she talks about the exciting new and ongoing pharmacogenomics research projects in Indonesia. She discussed the research partnerships, especially in the field of psychiatry and oncology, that she is working on. Dr Amel also explained the process of how the research partnerships are initiated and what are the common roadblocks faced during these processes.

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We invited our product data scientist, Yash, to our fifth episode of this series. He spearheaded the Covid Likelihood Meter initiative (www.covidmeter.id) for healthcare workers in inaccessible areas, in collaboration with Center for Indonesia's Strategic Development Initiatives (CISDI). Believing in machine learning and artificial intelligence's value in healthcare, he elaborated further on their potential in other disciplines of healthcare.

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The fourth episode brought Pingasari Tandrawijaya, Nalagenetics' mobile app product manager, to explain the importance of patient engagement in advancing clinical genetics in Indonesia. Ping introduced the Nala Personal Health Manager app with the idea of increasing the accessibility of clinical genetics and personalized healthcare for everyone in Indonesia. She also emphasized the importance of data privacy and security in this growing field, especially in a world where data breaches have been increasing at an alarming rate.

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In this third episode, dr Esther Widjaja sat down with the product manager of Nalagenetics, Astrid Karunia to discuss the rigors of developing a trustworthy clinical database.  Astrid K shared the thought process behind building a knowledge base as well as how does one goes about collecting genetic information from scientific publications and clinical guidelines. She also explained the rationale behind how she chose which gene to include in the report and how to determine the level of evidence that is sufficient for clinical use.

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For the second installment of this series, Fadhli Adesta discussed with Dr Astrid Irwanto, geneticist-turned-entrepreneur and Co-Founder of Nalagenetics to discuss the highs and lows of bringing genetics from bench to bedside.  Dr Astrid shared her personal story on how Nalagenetics developed from a research project in Papua to being the clinical genetics provider of choice for pharmacogenetics for some leading hospitals in Indonesia and Singapore. She also shares some insights on current development in genetics research as well as some advice for aspiring entrepreneurs in deep tech and medical tech.

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