Delve into the complexities of aging in the latest episode of "The Biology Brief," where hosts Kiley Grant and Dr. Jim Cardelli, the CEO and CTO of Oleolive, unravel the significance of senescence and explore the hallmarks of aging. In this thought-provoking discussion, we examine the dual nature of senescent cells, their positive roles in wound healing and potential positive role in cancer. Join us as we navigate the intriguing connections between senescent cells, exercise, and revolutionary CAR T therapy. Learn about UPAR as the target of CAR T cells, its associated costs, and the challenges in measuring the senescence burden in the body. Beyond UPAR, we explore other senescence markers, emphasizing the importance of targeting specificity in therapies. We'll also break down a relevant paper in this comprehensive exploration. Get a glimpse into the future with discussions on senolytic drugs and a preventive medicine approach.

Our company: https://www.oleo.live/

Buy Oligen here: https://oleocanthal.co/

Article we read: https://pubmed.ncbi.nlm.nih.gov/37841853/

0:40 What is senescence and why should we care?

1:12 What are the Hallmarks of aging?

2:07 Outline for Podcast and introduction of senescence cells.

3:40 Senescence cells can be positive and negative.

6:20 Senescence cells and cancer - positive role

9:20 Senescent cells and wound healing - positive role

12:30 Senescent cells - Breaking Bad

14:38 Senescent cells in the top 5 of the Hallmarks of aging

16:19 Senescent cells found throughout the body

18:46 Introduction to Paper to be discussed

20:45 Senescent cells and exercise

21:45 CAR T Therapy

23:30 UPAR found on senescent cells and the target of the CAR T cells

27:42 CAR T and cost

29:34 Can you measure the senescence burden in the body?

34:06 UPAR is not the only senescence marker.

35:00 Why targeting specificity is important.

37:00 Paper summary

37:43 Senolytic drugs on the horizon

41:00 Preventive medicine approach

42:08 Wrap up.