Neuro-Oncology: The Podcast

By Neuro-Oncology

What's Neuro-Oncology: The Podcast about?

Neuro-Oncology: The Podcast will keep you up to date about the latest advances in the field as we present conversations with the authors of selected papers from Neuro-Oncology and its sister journals, Neuro-Oncology Practice and Neuro-Oncology Advances.

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Neuro-Oncology: The Podcast episodes:

06.21.2024
Cancer stems cell in GBM
Dr. Iyad Alnahhas interviews Drs. Justin Lathia and Marco Gallo about their recent manuscript entitled "Cancer stem cell hypothesis 2.0 in glioblastoma: where are we now and where are we going?", published online in Neuro-Oncology in May 2024.
06.13.2024
Drug delivery across the blood-brain barrier
Dr. Ankush Bhatia interviews Dr. Keaton Piper about his and his team's manuscript, entitled "Consensus Review on Strategies to Improve Delivery Across the BBB Including Focused Ultrasound", published online in Neuro-Oncology in May 2024 Read Paper
05.24.2024
Gliomatosis cerebri in children
Dr. Evan Noch interviews Dr. Gunther Nussbaumer about his recent paper entitled: "Gliomatosis cerebri in children: a poor prognostic phenotype of diffuse gliomas with a distinct molecular profile" published online in Neuro-Oncology in May 2024.
05.17.2024
Immunotherapy drives mesenchymal shift in GBM
Dr. Maya Graham interviews Drs. Josephine Hendriksen and Joachim Weischenfeldt about their recent manuscript, "Immunotherapy drives mesenchymal tumour cell state shift and TME immune response in glioblastoma patients," published online in Neuro-Oncology in May 2024.
05.04.2024
Long-term outcomes of pediatric patients with optic pathway glioma
Dr. Iyad Alnahhas interviews Drs. Alice Morin, Samuel Abbou and Brice Fresneau about their recent manuscript entitled "Very long-term outcomes of pediatric patients treated for optic pathway gliomas: a longitudinal cohort study" published online in Neuro-Oncology in March 2024. Read...
04.12.2024
NF1 mutation and neuronal hyperexcitability
04.05.2024
Postoperative cerebellar mutism
Dr. Rachna Malani interviews Dr. Hrishikesh Suresh about his and his team's recent manuscript entitled "Postoperative cerebellar mutism syndrome is an acquired Autism-like network disturbance", published online in Neuro-Oncology in December 2023. Read the paper
03.22.2024
Cell cycle checkpoints and alkylating agents
Dr. Evan Noch interviews Dr. Chunzhang Yang about his and his team's recent manuscript entitled "Abrogation of the G2/M checkpoint as a chemo sensitization approach for alkylating agents" published online in Neuro-Oncology in December 2023 Read Paper
03.15.2024
Liquid biopsy in CNS lymphoma
Dr. Iyad Alnahhas interviews Dr. Ricardo Soffietti about the recent RANO review entitled "Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: a RANO review" published online in Neuro-Oncology in March 2024. Read the paper
03.08.2024
Immunotherapy for glioblastoma, lessons learned
Dr. John Fortunato interviews Dr. Antonio Chiocca about his and his team's recent manuscript entitled "Lessons learned from phase 3 trials of immunotherapy for glioblastoma: time for longitudinal sampling?" published online in Neuro-Oncology in February 2024. Get paper.
02.27.2024
TERTp mutation clonality in glioma
Dr. Maya Graham interviews Dr. Joseph Costello about his and his team's recent manuscript entitled "Whole tumor analysis reveals early origin of the TERT promoter mutation and intracellular heterogeneity in TERT expression", published online in Neuro-Oncology in December 2023.
02.09.2024
Liquid biopsy in H3K27M glioma
Description: Dr. Maya Graham interviews Dr. Carl Koschmann about his and his team's recent manuscript entitled: "Liquid biopsy in H3K27M diffuse midline glioma", published online in Neuro-Oncology in December 2023. Download PDF
01.26.2024
Glioma genetic profiles and electrophysiologic hyperexcitability
Dr. Iyad Alnahhas interviews Dr. Steven Tobochnik about his and his team's recent manuscript entitled "Glioma genetic profiles associated with electrophysiologic hyperexcitability", published online in Neuro-Oncology in Sep 2023. Read paper
01.12.2024
Epidemiology of glioma in Belgium
Dr. Jasmin Jo interviews Dr. Harry Pinson about his and his team's recent manuscript entitled: "Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era" Read Paper
12.23.2023
The Biology of H3K27M Mutant Gliomas
Dr. Iyad Alnahhas interviews Dr. Amanda Saratsis about her recent manuscript entitled: "H3K27M Mutant Glioma: Disease Definition and Biological Underpinnings", published online in Neuro-Oncology in October 2023. Read Paper
12.01.2023
3D tumor volume assessment in PCNSL
Dr. Rachna Malani interviews Dr. Florian Scherer about his and his team's recent manuscript entitled: "Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas", published online in Neuro-Oncology in Sep 2023. Link: https://pubmed.ncbi.nlm.nih.gov/37713267/
11.17.2023
Brain-tumor related epilepsy; a SNO consensus review
Dr. John Fortunato interviews Drs. Edward Avila and Steven Tobochnik about their recent manuscript entitled: "Brain tumor-related epilepsy management: A society for neuro-oncology consensus review on current management", published online in Neuro-Oncology in June 2023. Read Paper
10.27.2023
Vorasidenib and grading of IDH mutant astrocytoma
Description: Dr. Ankush Bhatia interviews Dr. Matthias Preusser about the recent letter in Neuro-Oncology, entitled: "What is an isocitrate dehydrogenase-mutated central nervous system World Health Organization grade 2 glioma, or who should receive vorasidenib?", published in July 2023.
10.06.2023
Insulin feedback and PI3K inhibition in GBM
Description: Dr. Maya Graham interviews Dr. Evan Noch about his and his team's recent manuscript entitled: "Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma", published online in Neuro-Oncology in July 2023. Read Paper
09.22.2023
SOX10 indel mutations in schwannomas
Dr. Evan Noch interviews Dr. David Solomon about his and his team's recent manuscript entitled: "Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs", published online in Neuro-Oncology in July 2023. Read Paper
09.08.2023
Dendritic cell vaccines in gliomas
Dr. Iyad Alnahhas interviews Drs. Kelly Hotchkiss and Mustafa Khasraw about their recently published review entitled: "Dendritic cell vaccine trials in gliomas: untangling the lines", published online in Neuro-Oncology in June 2023. Read Paper
08.11.2023
Intrathecal trastuzumab for leptomeningeal metastases
Dr. Iyad Alnahhas interviews Drs. Priya Kumthekar and Jeffrey Raizer about their recent manuscript entitled: A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2- positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal...
07.21.2023
Short term topiramate for radiation induced cytotoxic edema
Dr. Iyad Alnahhas interviews Drs. Maria Jose Contreras-Zarate and Diana Cittelly about their recent manuscript entitled: "Short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis", published online in Neuro-Oncology in April 2023. Read...
07.08.2023
Venous thromboembolism in gliomas
Description: Dr. Maya Graham interviews Drs. Jasmin Jo, Craig Horbinski and David Schiff about their recent manuscript entitled: "Epidemiology, biology and management of venous thromboembolism in gliomas: an interdisciplinary review", published online in Neuro-Oncology in April 2023. Read Paper
06.23.2023
RANO resect
Dr. Iyad Alnahhas interviews Dr. Philipp Karschnia about his and his team's recent manuscript entitled "Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group", published online in Neuro-Oncology in...
06.09.2023
Methylation profiling of adult ependymoma
Dr. Evan Noch interviews Dr. David Kaul about his and his team's recent manuscript entitled: "Adult intracranial ependymoma—relevance of DNA methylation profiling for diagnosis, prognosis, and treatment", published online in Neuro-Oncology in February 2023. Read Paper
05.12.2023
Pseudoprogression in IDH-mutant high-grade gliomas
Dr. Ankush Bhatia interviews Dr.François Ducray about his and his team's recent manuscript entitled:"Incidence and characteristics of pseudoprogression in IDH-mutant high-grade gliomas: A POLA network study", published online in Neuro-Oncology in March 2023.
04.21.2023
Changes in survival outcomes in melanoma patients with brain metastases
Dr. Iyad Alnahhas interviews Drs. Sherise Ferguson and Michael Davies about their recent manuscript entitled: "Changes in Outcomes and Factors Associated with Survival in Melanoma Patients with Brain Metastases", published online in Neuro-Oncology in December 2022. Read Paper
04.07.2023
Radiation therapy and structural brain changes
Dr. Evan Noch interviews Drs. Nikhil Rammohan and Kathleen Bandt about their recent manuscript entitled "Whole-brain radiotherapy associated with structural changes resembling aging as determined by anatomic surface-based deep learning", published online in Neuro-Oncology in February 2023. Read...
03.17.2023
Objective response rate targets for recurrent glioblastoma clinical trials
Dr. Maya Graham interviews Drs. Benjamin Ellingston and Timothy Cloughesy about their recently published manuscript entitled: "Objective response rate (ORR) targets for recurrent glioblastoma clinical trials based on the historic association between ORR and median overall survival", published online in...
03.03.2023
Mitotic count prognostic significance in IDH-mutant astrocytoma in the molecular era
Dr. Iyad Alnahhas interviews Dr. Max Kros about his and his team's recent manuscript entitled: "Mitotic count is prognostic in IDH-mutant astrocytoma without homozygous deletion of CDKN2A/B. Results of consensus panel review of EORTC trials 26053 and EORTC 22033-26033",...
02.10.2023
Palliative care in neuro-oncology
Dr. Iyad Alnahhas interviews Drs. Tobias Walbert and Johan Koekkoek about their recent manuscript entitled "Palliative care and end-of-life care in adults with malignant brain tumors", published online in Neuro-Oncology in October 2022 Read Paper
01.27.2023
Nivolumab in MGMT methylated GBM
Description: Dr. Jasmin Jo interviews Dr. Michael Lim about his and his team's recent manuscript entitled: "Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter", published online in Neuro-Oncology in November 2022.
01.13.2023
IDH mutant gliomas; SNO consensus Review
Description: Dr. Ankush Bhatia interviews Drs. Julie Miller, Nicolas Gonzalez Castro, Samuel McBrayer and Patrick Wen about their recent manuscript, entitled: "Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions",...
12.30.2022
DNA methylation subclass and extent of GBM resection
Dr. Evan Noch interviews Drs. Richard Drexler and Franz Ricklefs about their recent manuscript entitled: "DNA methylation subclasses predict the benefit from gross total tumor resection in IDH-wildtype glioblastoma patients", published online in Neuro-Oncology in July 2022. Full Report
12.16.2022
Pre-operative [11C]methionine PET for low-grade glioma
Description: Dr. Maya Graham interviews Drs. Gaia Ninatti and Martina Sollini about their recent manuscript entitled: "Pre-operative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomas", published online in Neuro-Oncology in September 2022. Full Report
12.02.2022
The role of T lymphocytes in the glioma pathobiology
Dr. Iyad Alnahhas interviews Dr. David Gutmann about the review entitled "T lymphocytes as dynamic regulators of glioma pathobiology", published online in Neuro-Oncology in March 2022. Read paper
10.08.2022
CDKN2A homozygous deletion in IDH mutant astrocytoma
Dr. Evan Noch interviews Drs. Shannon Fortin Ensign and Sani Kizilbash about their recent paper in Neuro-Oncology entitled: "Translational significance of CDKN2A/B homozygous deletion in IDH mutant astrocytoma", published online in Neuro-Oncology in August 2022 Full Report
09.23.2022
EGFR: the lazarus target in glioblastom
Dr. Maya Graham interviews Drs. Benjamin Lin, David Nathanson, Frank Furnari and Ryan Miller about their recent manuscript entitled: "EGFR, the Lazarus target for precision oncology in glioblastoma", published online in Neuro-Oncology in September 2022.
09.09.2022
Brain metastases; a SNO consensus review: Part 2
In this second of two episodes, Dr. Iyad Alnahhas interviews Drs. Ross Camidge, Michael Davis, Nancy Lin and Ayal Aizer about the recent editorial review entitled: "Brain Metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future...
08.26.2022
Brain metastases; a SNO consensus review: Part 1
In this first of two episodes, Dr. Iyad Alnahhas interviews Drs. Ayal Aizer, Eudocia Lee and Veronica Chiang about the recent editorial review entitled: "Brain Metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions", published online...
08.13.2022
Pediatric IDH mutant gliomas
Dr. Iyad Alnahhas interviews Drs. Jennifer Cotter and Kee Kiat Yeo about their recent paper entitled: ""Multi-institutional study of the frequency, genomic landscape and outcome of IDH-mutant glioma in pediatrics", published online in Neuro-Oncology in May 2022. Full...
07.29.2022
Low-risk meningioma: Outcomes from NRG 0539
Dr. Jasmin Jo interviews Dr. Leland Rogers about his and his team's recent manuscript entitled: "Low-risk meningioma: initial outcomes from NRG Oncology/RTOG 0539", published online in Neuro-Oncology in June 2022 Full Article
07.01.2022
Selumetinib in children with NF1 and plexiform neurofibroma
Dr.Iyad Alnahhas interviews Drs. Andrea Gross and Brigitte Widemann about their manuscript entitled "Selumetinib in Children with Neurofibromatosis Type 1 and Asymptomatic Inoperable Plexiform Neurofibroma at Risk for Developing Tumor-Related Morbidity", published online in Neuro-Oncology in April 2022. ...
06.17.2022
Targeted therapy for BRAF-mutant pediatric glioma
Dr. Evan Noch interviews Drs. Kee Kiat Yeo and Matthias Karajannis about their recent manuscript entitled: "Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high grade glioma", published online in Neuro-Oncology in April 2022. Link to article
05.20.2022
Early/evolving IDH wild-type glioblastoma
Description: Dr. Maya Graham interviews Dr. David Solomon about his and his team's recent manuscript entitled: "Prospective genomically-guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes", published online in Neuro-Oncology in April 2022. Read Article
05.06.2022
PI3K signaling in IDH mutant gliomas
Dr. Evan Noch interviews Dr. Joanna Phillips about her and her team manuscript entitled: "PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications", published online in Neuro-Oncology in March 2022.
04.22.2022
Cell-free DNA from CSF in pediatric, adolescent and young adult patients
Dr. Iyad Alnahhas interviews Dr. Matthias Karajannis about his and his team's recent manuscript entitled: "Next-generation sequencing of cerebrospinal fluid for clinical molecular diagnostics in pediatric, adolescent and young adult (AYA) brain tumor patients", published in Neuro-Oncology in February 2022
04.08.2022
Molecular determinants of neurocognitive deficits in glioma
Dr. Ankush Bhatia interviews Dr. Emma van Kessel about her and her team's recent manuscript entitled "Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma", published online in Neuro-Oncology in February 2022. Full Report
03.25.2022
H3K27M cell-free tumor DNA tracking in response to ONC201 treatment for diffuse midline glioma
Dr. Iyad Alnahhas interviews Dr. Carl Koschmann about his and his team's recent manuscript entitled: "Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma" published online in Neuro-Oncology in February 2022. Read...

What's Neuro-Oncology: The Podcast about?

Download our free app to listen on your phone

Neuro-Oncology: The Podcast episodes:

Cancer stems cell in GBM

Drug delivery across the blood-brain barrier

Gliomatosis cerebri in children

Immunotherapy drives mesenchymal shift in GBM

Long-term outcomes of pediatric patients with optic pathway glioma

NF1 mutation and neuronal hyperexcitability

Postoperative cerebellar mutism

Cell cycle checkpoints and alkylating agents

Liquid biopsy in CNS lymphoma

Immunotherapy for glioblastoma, lessons learned

TERTp mutation clonality in glioma

Liquid biopsy in H3K27M glioma

Glioma genetic profiles and electrophysiologic hyperexcitability

Epidemiology of glioma in Belgium

The Biology of H3K27M Mutant Gliomas

3D tumor volume assessment in PCNSL

Brain-tumor related epilepsy; a SNO consensus review

Vorasidenib and grading of IDH mutant astrocytoma

Insulin feedback and PI3K inhibition in GBM

SOX10 indel mutations in schwannomas

Dendritic cell vaccines in gliomas

Intrathecal trastuzumab for leptomeningeal metastases

Short term topiramate for radiation induced cytotoxic edema

Venous thromboembolism in gliomas

RANO resect

Methylation profiling of adult ependymoma

Pseudoprogression in IDH-mutant high-grade gliomas

Changes in survival outcomes in melanoma patients with brain metastases

Radiation therapy and structural brain changes

Objective response rate targets for recurrent glioblastoma clinical trials

Mitotic count prognostic significance in IDH-mutant astrocytoma in the molecular era

Palliative care in neuro-oncology

Nivolumab in MGMT methylated GBM

IDH mutant gliomas; SNO consensus Review

DNA methylation subclass and extent of GBM resection

Pre-operative [11C]methionine PET for low-grade glioma

The role of T lymphocytes in the glioma pathobiology

CDKN2A homozygous deletion in IDH mutant astrocytoma

EGFR: the lazarus target in glioblastom

Brain metastases; a SNO consensus review: Part 2

Brain metastases; a SNO consensus review: Part 1

Pediatric IDH mutant gliomas

Low-risk meningioma: Outcomes from NRG 0539

Selumetinib in children with NF1 and plexiform neurofibroma

Targeted therapy for BRAF-mutant pediatric glioma

Early/evolving IDH wild-type glioblastoma

PI3K signaling in IDH mutant gliomas

Cell-free DNA from CSF in pediatric, adolescent and young adult patients

Molecular determinants of neurocognitive deficits in glioma

H3K27M cell-free tumor DNA tracking in response to ONC201 treatment for diffuse midline glioma