In this episode of Neuroscience Perspectives, we speak with Dr. Shafali Jeste, an internationally recognized child neurologist whose research has advanced the identification of early biomarkers that predict autism spectrum disorder and epilepsy in infants with Tuberous Sclerosis Complex. Dr. Jeste shares how brain imaging and EEG are advancing our understanding of infant brain development. Dr. Jeste is Chair and Executive Medical Director of Pediatrics at the David Geffen School of Medicine at UCLA, and Executive Director of the Children’s Discovery and Innovation Institute. From autism biomarkers to translational research, this conversation highlights how neuroscience is improving care for children with neurodevelopmental disorders and developmental disabilities. Subscribe for more episodes from Neuroscience Perspectives, featuring researchers from the University of Rochester and those who visit.

#neuroscience #podcast #autism #research #Neurodevelopment #braindevelopment #sciencepodcast #womeninscience #autismawareness

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🧠 Experts in this Episode

Shafali Jeste, MD: https://teams.semel.ucla.edu/tarjan/team/shafali-jeste-md

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

🧠How do memories form in the brain? How do individual neurons create memories? In this episode of Neuroscience Perspectives, Ueli Rutishauser, PhD, professor of Neurosurgery, Neurology & Biomedical Sciences, and director of Human Neurophysiology Research and the Center for Neural Science and Medicine at Cedars-Sinai, explores groundbreaking neuroscience research on memory formation, learning, and neural activity in the human brain. Using single-neuron recordings, Dr. Rutishauser explains to Dr. John Foxe how the hippocampus and other brain regions encode episodic memory and cognition. This conversation dives into how brain cells communicate, how memories are formed and retrieved, and why studying neurons at the single-cell level is transforming cognitive neuroscience.

We caught up with Dr. Rutishauser in San Diego at the Society for Neuroscience Conference #SfN25

#Brain #Science #HowTheBrainWorks #MindAndBrain #MemoryScience #BrainFacts #NeuroscienceExplained #ScienceEducation #STEM #Research #Podcast #LongFormContent

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🧠Experts in this Episode:

Ueli Rutishauser, PhD: https://researchers.cedars-sinai.edu/Ueli.Rutishauser

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

🧠Labs Mentioned:

Rutishauser Lab: https://www.cedars-sinai.edu/health-sciences-university/research/labs/rutishauser.html

Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG

In this episode of Neuroscience Perspectives, Dr. Anne Churchland, professor of Neurobiology at the David Geffen School of Medicine and the Brain Research Institute at the University of California, Los Angeles, explores how the brain transforms sensory information into decisions. Through the use of neuroscience, mouse models, and data analysis, she examines the neural circuits in the cortex that connect perception, attention, learning, and behavior. This conversation highlights cutting-edge brain research, offering insight into how brain signals shape choice and cognition.

Dr. Churchland gave the Notter Lecture at the University of Rochester Medical Center in 2021: https://www.youtube.com/watch?v=J8eVajX4ZjA

We caught up with her in San Diego at the Society for Neuroscience Conference #SfN25 #neuroscience #sciencefacts #DecisionMaking #podcast #science #sciencepodcast

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Experts in this Episode: Anne Churchland, PhD: https://bri.ucla.edu/people/anne-churchland/

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

Labs Mentioned: Churchland Lab: https://churchlandlab.dgsom.ucla.edu/

Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG

Join this conversation with the world-renowned neurosurgeon and neuroscientist, Dr. Itzhak Fried. In this episode of Neuroscience Perspectives, Dr. Fried, professor of neurosurgery, psychiatry, and biobehavioral sciences, and co-director of the UCLA Seizure Disorder Center at the UCLA School of Medicine he is a pioneering researcher and recipient of major international awards, including the Ramon y Cajal and Tsubokawa Awards—joins us to explore the neural basis of memory, will, and human behavior.

From developing methods to record single neurons in the human brain to investigating how we might prevent “cognitive catastrophe” through minimally invasive memory prosthetics, Dr. Fried’s work is reshaping our understanding of consciousness itself. He discusses breakthroughs born from epilepsy surgery, the famous “Jennifer Aniston neuron,” and what his international clinical and research career has taught him about the future of neuroscience.

#Neuroscience #BrainResearch #EpilepsySurgery #Science #memory #memory #CognitiveNeuroscience #NeuralRecording #ConsciousnessStudy #BrainHealth #sciencepodcast #podcast

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🧠Experts in this Episode:

Itzhak Fried, MD, PhD: https://www.uclahealth.org/providers/itzhak-fried

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

🧠Labs Mentioned:

Cognitive Neurophysiology Laboratory: https://friedcnl.ucla.edu/team/ Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG

In this episode of Neuroscience Perspectives, host John Foxe, PhD, sits down with neuroscientist and New York Times bestselling author Dr. Lisa Genova — acclaimed for her groundbreaking novel Still Alice and her powerful storytelling that brings neurological diseases to life. Dr. Genova bridges science and storytelling to deepen public understanding of conditions such as Alzheimer’s, Huntington’s, ALS, autism, and bipolar disorder, inspiring empathy for those affected and reshaping how these diseases are perceived beyond the lab and clinic. Watch to explore how narrative can be a powerful tool for translating neuroscience, fostering compassion, and influencing the dialogue around brain health. #Neuroscience #BrainHealth #LisaGenova

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Experts in this Episode:

Lisa Genova, PhD: https://www.lisagenova.com/

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

In this episode of Neuroscience Perspectives, Steven Goldman, MD, PhD, URMC Distinguished Professor in Neurosciences at the University of Rochester Medical Center, discusses groundbreaking neuroscience research on brain cell repair, stem cell therapy, and regenerative medicine. Learn how his early research in birds has led to research that shows the adult brain can generate new neurons that integrate into key motor circuits. These findings demonstrate that stimulating natural brain processes may help repair damaged neural networks in Huntington's and other diseases. Dr. Goldman described decades of research in glial cells that are shaping our understanding of brain health and allowing the exploration of new approaches to treating Huntington’s disease, multiple sclerosis, and Alzheimer’s disease. #Neuroscience #BrainHealth #StemCells #Alzheimers #MultipleSclerosis #RegenerativeMedicine #Neurodegeneration #Podcast

In this episode of Neuroscience Perspectives, take on the complex circuits of the brain with Jessica Cardin, PhD, professor of neuroscience at Yale University School of Medicine. Join host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester, as he and Dr. Cardin discuss how brain states shift—from zoning out to laser focus—and the chemical signals and non-neuronal cells that help drive those changes. Discover how her lab is harnessing new technologies and big data approaches, including machine learning, to unravel how the brain integrates countless signals to guide decision-making and behavior. From exploring autism- and schizophrenia-related genes to studying models of aging and Alzheimer’s disease, Cardin’s research highlights both the promise and the challenges of understanding such a complex system. Subscribe to Neuroscience Perspectives today! #podcast #neuroscience #science #research #brain

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Experts in this Episode: Jessica Cardin, PhD: https://medicine.yale.edu/profile/jess-cardin/ John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

Labs Mentioned: Cardin Lab: https://cardinlab.org Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG

In this episode of Neuroscience Perspectives, we explore one of medicine’s most complex and pervasive challenges—chronic pain. Host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester, sits down with Paul Geha, MD, associate professor of Psychiatry, Neuroscience, Neurology, and Dentistry at the University of Rochester Medical Center. Together, they unpack the ways our brains perceive pain and the impact it can have on well-being.Dr. Geha shares his research into how brain connectivity and structure change in patients with chronic pain—and how these changes might help us predict who is at risk for conditions like low back pain or failed surgery outcomes. They discuss the psychological dimensions of pain, the challenges of diagnosis and treatment, and how research is charting a new course to change traditional injury-based models of pain.Could brain biomarkers reveal who is most vulnerable to chronic pain? Might psychedelics offer a new avenue for relief? And how can science better serve the millions suffering from pain that cannot be quantified in an exam or on a scan?

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🧠 Experts in this Episode:

Paul Geha, MD: https://www.urmc.rochester.edu/people/112361971-paul-geha

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe🧠

Labs Mentioned:

Geha Lab: https://www.urmc.rochester.edu/labs/geha

Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG

Join Dr. John Foxe, Director of the Del Monte Institute for Neuroscience at the University of Rochester, as he welcomes renowned neuroscientist Dr. Doris Tsao to Neuroscience Perspectives. Dr. Tsao shares how her pioneering research has transformed our understanding of how the brain processes visual information. Her lab helped discover that it only takes a few hundred neurons to encode any face – for reference, there are more than a few billion neurons in the brain. This conversation explores the intersection of neuroscience, math, and AI. We also discuss her academic journey—from Caltech to Harvard, and her current role at UC Berkeley. She also shares how having the right mentor was pivotal to her scientific training. Dr. Tsao shares the importance of science communication and what it means to pursue truth in a world shaped by both neural networks and human curiosity.

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🧠Experts in this Episode:

Doris Tsao, PhD: https://vcresearch.berkeley.edu/faculty/doris-tsao

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

🧠Labs Mentioned:

Tsao Lab: https://tsaolab.berkeley.edu/

Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG

Kia Nobre, PhD, is the director of the Center for Neurocognition and Behavior at the Wu Tsai Institute at Yale University. Her discoveries have revolutionized our scientific understanding of the human mind and brain. This episode was originally released on 6/20/2024. She tells John Foxe, PhD, director of the Del Monte Institute for Neuroscience, about the great gift she acquired as a child that leveraged her education at an early age. Nobre recently returned to her alma mater after spending the majority of her career at Oxford University where she held several leadership roles, including the director of the Oxford Centre for Human Brain Activity. #podcast #brain #neuroscience #humanbrain #humanbehavior #understanding #yaleuniversity #oxford

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🧠Experts in this Episode:

Kia Nobre, PhD: https://psychology.yale.edu/people/kia-nobre

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

🧠Labs Mentioned:

Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG

Brain & Cognition Laboratory: https://www.brainandcognition.org/