Neurotech Pub

This episode features Paradromics CEO Matt Angle in a compelling discussion with Amit Etkin, Founder and CEO of Alto Neuroscience; Maryam Shanechi, Dean's Professor in Electrical and Computer Engineering, Neuroscience, Computer Science, and Biomedical Engineering at USC; and Prasad Shirvalkar, Associate Professor of Neurological Surgery, Neurology and Anesthesia at UC San Francisco. They delve into the intersection of neurotechnology and psychiatry, discussing innovative approaches to treating mental health disorders, the potential of machine learning models, and the challenges associated with obtaining and analyzing brain data. The discussion emphasizes the importance of interdisciplinary collaboration and the promising future of personalized therapies for psychiatric conditions. They also address the limitations of current diagnostic tools like the DSM and the need for scalable, real-world solutions. 

Guest Quote:

“There's artificial intelligence and there's actual intelligence. And that actual intelligence, when it comes to analyzing data, I feel goes a really, really long way. True subject matter expertise.” - Amit Etkin

Timestamps:

*(00:00) Welcome to Neurotech Pub

*(00:45) Icebreaker: Unpopular Beliefs

*(05:36) Non-surgical brain activity recording and diagnostics

*(13:32) Understanding pain: Subjective reports vs. physical representations

*(16:33) Rethinking psychiatry and DSM alignment

*(21:07) Determining brain data needs and tool validation

*(26:47) The need for explainability in AI algorithms

*(35:49) Timescales in mental health interventions

*(41:22) Advice for aspiring neurotech researchers

*(46:25) Closing Thoughts 

Want More?

Learn about Neurotech Pub on Twitter

Follow Paradromics on Twitter, LinkedIn, and Instagram

Follow Matt on LinkedIn and Twitter

This episode features Paradromics CEO Matt Angle in a compelling discussion with Sumner Norman, Co-founder & CEO at Forest Neurotech; Ryan Field,CEO at Kernel; and Mary Lou Jepsen, Founder and CEO of Openwater. They share their career influences, discuss the challenges of managing interdisciplinary teams, and explore the future of neuroimaging and brain-computer interfaces (BCIs). Delving into ultrasound and optical-based techniques, they highlight the transformative potential of non-invasive methods for diagnosing and treating brain conditions. Furthermore, they addresses regulatory hurdles, the evolution of focused research organizations, and offers valuable advice for early-career researchers on leveraging industry trends and fundamental research to drive technological advancements.

Guest Quote:

“And I think what we're trying to work on is the silicon hospital of the future with this capability, like the modern smartphone, that can reach everybody, regardless of income levels or borders.” - Mary Lou Jepsen

Timestamps:

*(00:00) Welcome to Neurotech Pub

*(00:06) Meet the Guests

*(02:48) Balancing Mentorship and Startup Demands

*(05:36) Interdisciplinary Challenges in Neurotech

*(07:11) Hardware Development and Efficiency

*(18:12) Medical Device Development and Regulatory Challenges

*(23:37) Technical Deep Dive: Optical and Acoustic Signatures

*(24:00) Ultrasound in Brain-Computer Interfaces

*(34:57) Near-Infrared Spectroscopy and Mental Health

*(55:55) Understanding Stroke and Thrombectomy

*(56:51) Innovations in Cancer Treatment and Blood Flow Analysis

*(57:39) Challenges and Trials in Medical Technology

*(58:42) Open Source Medical Technology and Global Collaboration

*(58:59) The Evolution of Brain-Computer Interfaces

*(01:02:42) Advancements in Ultrasound Technology

*(01:03:39) The Role of MEMS and Silicon in Medical Devices

*(01:09:29) The Importance of Fundamental Research

*(01:14:48) The Future of Neurotechnology and Industry Trends

*(01:17:58) Advice for Aspiring Researchers and Entrepreneurs

*(01:29:41) Leadership and Transition in Tech Companies

*(01:40:07) Focused Research Organizations and Their Impact

*(01:46:08) Final Thoughts and Optimism for Neurotech

Want More?

Learn about Neurotech Pub on Twitter

Follow Paradromics on Twitter, LinkedIn, and Instagram

Follow Matt on LinkedIn and Twitter

This episode features Paradromics CEO Matt Angle in a compelling discussion with Grayson Zulauf, CEO of Resonant Link; Alex Yeh, CTO and VP of R&D at Neuspera Medical; and Jacob Robinson, Founder and CEO of Motif Neurotech. They explore the latest advancements in neurotechnology, focusing on wireless power transfer, implantable devices, and brain-computer interfaces (BCIs). The conversation highlights transformative innovations in treating mental health conditions like major depressive disorder, OCD, and ADHD with less invasive wireless devices, enhancing patient care and acceptance. Personal stories and insights on market expansion and patient-friendly treatments are shared, along with valuable advice for investors on the potential of neurotechnology in improving overall mental health and medical care.

Guest Quote:

“The message that I would want to send is, there is a future in which we look at neurotechnologies no differently than we look at cardiac pacemakers.

These are life saving devices, in many cases less invasive than a device that goes in your heart. There's no reason why  anybody wouldn't want to feel better. To be healthier mentally and just live a better quality of life. So that's what we're trying to enable” - Jacob Robinson

Show Notes:

*(00:00) Welcome to Neurotech Pub

*(00:46) Meet the Guests

*(02:45) Discussing Industry Competitors

*(09:54) Wireless Power Transfer in Medical Devices

*(16:38) Exploring Inductive and Magnetoelectric Power

*(27:35) Ultrasound in real-world devices

*(33:31) Patient Experience and Device Miniaturization

*(36:24) Designing for Patient Comfort and Practicality

*(38:20) Innovations in Power and Data Transmission

*(39:32) Miniaturization and Its Impact

*(41:12) Battery Technology in Medical Devices

*(43:19) Future of Implantable Batteries

*(45:16) Implanted Battery Companies Integer and Resonetics

*(46:31) Intermittent Stimulation and Therapy

*(49:28) Power Consumption in Future Implants

*(59:52) Data Transmission and Compression

*(01:05:42) Reflections on the Journey of Medical Innovation

*(01:08:36) Final Thoughts and Messages to Investors

Want More?

Follow Neurotech Pub on Twitter

Follow Paradromics on Twitter, LinkedIn, and Instagram

Follow Matt on LinkedIn and Twitter

We’re back with Part II of our two-part series on Connectomics! 

In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome. 

Our guests are: 

In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv, as well as his published work at Google. 

If you missed part one, you can listen and explore the show notes here. Cheers!

Show Notes: 

0:00 | Intro

1:03 | Kenneth Hayworth, PhD

1:12 | Robert McKintyre, CEO, Nectome

1:17 | Jeremy Maitin-Shepard, PhD

1:51 | Setting the record straight 

3:09 | The nucleotide sequence of bacteriophage φX174

4:22 | Frozen Zoo at San Diego Zoo

12:01| Glutaraldehyde and reduction techniques for immunolabeling 

17:39 | SWITCH Framework

19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude 

Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects 

Permeabilization-free en bloc immunohistochemistry for correlative microscopy 

19:57 | Synaptic Signaling in Learning and Memory 

Structure and function of a neocortical synapse 

Engineering a memory with LTD and LTP 

Synapse-specific representation of the identity of overlapping memory engrams 

20:28 | Ultrastructure of Dendritic Spines

Structure–stability–function relationships of dendritic spines 

24:25 | Reconstructing the connectome 

24:32 | Connectomics Research Team at Google 

24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome 

28:38 | Serial Block-Face Scanning Electron Microscopy 

29:22 | Automated Serial Sections to Tape

29:45 | Mapping connections in mouse neocortex

30:59 | A connectome and analysis of the adult Drosophila central brain 

32:14 | Expansion Microscopy

34:37 | The future of connectomics 

45:13 | Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons

49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task 

Want More?

Follow Neurotech Pub on Twitter

Follow Paradromics on Twitter, LinkedIn, and Instagram

Follow Matt on LinkedIn and Twitter

Welcome back to Neurotech Pub! 

In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries. 

Our guests are: 

As an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon.

Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon!

Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting.

Show Notes: 

0:00 | Episode Intro 

1:16 | Nita A. Farahany, JD, PhD

1:21 | Kenneth Hayworth, PhD

1:27 | Robert McKintyre, CEO, Nectome

1:56 | Meeting of the minds 

2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize

3:56 | The Brain Preservation Foundation

4:09 | Documentary series on the Brain Preservation Foundation

5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats)

5:51 | Nita's 2018 Neuroethics Ted Talk 

5:54 | International Neuroethics Society

6:25 | Connectomics & new paths in neuroscience 

8:10 | Allen Institute for Brain Science

8:47 | A connectome and analysis of the adult Drosophila central brain

9:33 | A visual intro to synaptic imaging in connectomics

10:28 | The structure of the nervous system of the nematode Caenorhabditis elegans 

11:16 | Mouse Connectome Project at CIC

14:59 | Cryonics controversy 

19:00 | Death, taxes, and synapses 

20:51 | Uniform Law Commission

21:08 | The Uniform Determination of Death Act

24:25 | Watch Altered Carbon on Netflix

25:49 | Understanding the “Loss of Chance” Doctrine 

37:13 | Understanding Physician-Assisted Death, or ‘Death with Dignity’ 

40:21 | Euthanasia in the Netherlands

46:01 | Autonomy, Dignity, and Consent to Harm, Rutgers Law Review 

Want More?

Follow Neurotech Pub on Twitter

Follow Paradromics on Twitter, LinkedIn, and Instagram

Follow Matt on LinkedIn and Twitter

Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity. 

Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine.

This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode.

Cheers!

Show Notes: 

00:00 | Episode intro with Matt Angle and Amy Kruse

1:07 | StimScience in Fast Company

5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep

6:43 | Connect with Prime Movers Lab

7:01 | PML on Medium

7:45 | Introduction to Sleep Stages

References: 

Stages of Sleep Overview 

REM vs Non-REM Sleep

Sleep Walking

Benefits of REM Sleep

Consequences of low REM sleep

Importance of Deep Sleep

Check out Zoe’s nonprofit organization, ALS Heroes, and her Ted Talk

12:24 | Pulling all-nighters

12:50 | Amy Kruse, PhD

13:00 | Ram Gurumoorthy, PhD

13:07 | Stimscience, now Somnee

13:30 | Luis de Lecea, PhD

18:26 | Gordon Rule, PhD

18:40 | Knights of the Old Republic II: The Sith Lords (2004)

19:50 | Why do we sleep?

20:26 | Sleep drives metabolite clearance from the adult brain

20:35 | Sleep & DNA Repair

22:13 | Neural Activity can cause DNA damage

23:22 | Jerry Seigal

24:26 | DARPA Sleep Research

24:55 | Fur seals and sleep

25:08 | How do Whales and Dolphins Sleep Without Drowning?

25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars

27:36 | Sleep and Mortality

28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices

28:27 | Giulio Tononi, MD, PhD

28:45 | Sleep, Memory, and Plasticity

28:52 | Sleep Cognition and Memory

29:00 | Sleeping up and down the phylogenetic tree

29:05 | Actually...worms do sleep

29:20 | Decoding sleep

29:36 | Fruit flies and their mini sleeps

29:44 | Mapping sleep in the brain

30:35 | Hypocretin-positive neurons

31:17 | Clearly Matt slept through his midterm... again

31:57 | The hypocretins/orexins: integrators of multiple physiological functions

32:05 | Stress-sleep interactions

33:30 | The Science of Narcolepsy

35:08 | Equivalence of sleep deprivation and intoxication | Additional reference

36:21 | Sleep Pressure: Homeostatic Sleep Drive 

40:38 | EEG Visualization of electrodermal activity during sleep

44:08 | Circuitry of Sleep Stages

45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats

48:00 | Emerging Sleep Technologies

1:00:56 | Hypothalamus and Sleep

Want More?

Follow Neurotech Pub on Twitter

Follow Paradromics on Twitter, LinkedIn, and Instagram

Follow Matt on LinkedIn and Twitter

The Panel: 

Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn. 

Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram. 

Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin. 

00:00 | Intro

0:14 | Neurotech Pub Episode 13: BCI Pioneers Part I

0:47 | Neurotech Pub Episode 10: Business Models in Neurotech

1:30 | BCI & Identity

1:30 | New Yorker - Do Brain Implants Change Your Identity?

2:09 | The Utah Array (Blackrock Neurotech)

16:05 | Learn more about Hector in Part 1

17:14 | Talking Form Factors

18:36 | CerePlex System

22:36 | Support Systems in BCI Adoption

38:35 | Get in Touch

38:54 | The Ian Burkhart Foundation

39:13 | Book Ian as a speaker

39:25 | North American Spinal Cord Injury Consortium (NASCIC)

40:04 | Where to find Ian

40:19 | Contact Nathan

40:25 | Nathan on Instagram, LinkedIn, and Twitter

40:32 | Nathan's NFTs on OpenSea

Links to Jan’s lab photos and how to get in touch can be found here

Want More?

Follow Paradromics on Twitter, LinkedIn, and Instagram

Follow Blackrock Neurotech on Twitter, LinkedIn, and Instagram

Follow Taryn on LinkedIn, Instagram, and Twitter

Follow Matt on LinkedIn and Twitter

In this very special two part series in collaboration with Blackrock Neurotech, Paradromics CEO Matt Angle and Blackrock Creative Director Taryn Southern co-host a discussion with BCI research pioneers Jan Scheuermann, Ian Burkhart, and Nathan Copeland. In part one, we discuss their personal journeys to becoming BCI pioneers, implant experiences with the Utah Array,  their time in the lab, and some of their current projects. Learn more about Jan, Ian, and Nathan below and stay tuned for part two, coming in July 2022! 

The Panel: 

Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn. 

Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram. 

Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin. 

00:00 | Intro

6:10 | Who came first?

7:07 | Jan Scheuermann

7:18 | Tim Hemmes & the UPitt/UPMC Team

8:05 | New Yorker profile of Jan and the UPitt team

8:55 | View Jan’s photos from the lab

10:10 | Nathan Copeland

13:00 | Parietal Cortex

13:22 | Saccade Movements

14:12 | The Pioneer Experience

16:04 | Neuro Life Study | Additional Reference | Interview with Ian | Archives of PMR

18:15 | Mirror Therapy

23:50 | Jan in the Pilot Seat

25:07 | Ian's Experience in the Car Simulator

25:53| Thinking About Thinking

31:24 | Jan's novel, Sharp as a Cucumber

37:37 | View Jan’s photos from the lab

38:04 | Andy Schwartz

38:45 | Nathan's NFTs

43:22 | Nathan's Instagram

45:03 | 15 Minutes of Fame

45:12 | A Presidential Greeting

45:45 | Jan on 60 Minutes

45:54 | Jan in SciAM

46:00 | Book Jan as a keynote speaker

46:32 | SfN

47:05 | Investment in BCI

47:17 | The Ian Burkhart Foundation

Want More?

Follow Paradromics on Twitter, LinkedIn, and Instagram

Follow Blackrock Neurotech on Twitter, LinkedIn, and Instagram

Follow Taryn on LinkedIn, Instagram, and Twitter

Follow Matt on LinkedIn and Twitter

Welcome back to Neurotech Pub!

This episode is part two of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD,  Mark Schnitzer, PhD, and Jacob Robinson, PhD. Last time we talked about optical recording methods, but in this episode we focus on optical stimulation methods. 

Cheers!

Check out video and full transcript here: https://www.paradromics.com/podcast/episode-12-mind-control-with-lasers

00:00 | Intro

1:37 | Aspirational Papers

1:56 | Packer Lab 

2:10 | What is the claustrum?

2:30 | Ian's paper (but only part of it!)

3:02 | Two-Photon Bidirectional Control and Imaging In Vivo

3:29 | Inferring Spikes from Calcium Imaging

5:45 | Neuropixels are now in humans

7:12 | Paper by Pachitariu et al 

7:55 | Ian Oldenburg

10:02 | Kaufman Lab

11:21 | Cortical activity in the null space: permitting preparation without movement

12:08 | Motor cortical dynamics shaped by multiple distinct subspaces during naturalistic behavior

12:33 | Tickling Cells with Light

14:41 | Light-activated ion channels for remote control of neuronal firing

14:50 | Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons

15:20 | Millisecond-timescale, genetically targeted optical control of neural activity

16:03 | Red-shifted Opsins

16:52 | eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications

17:26 | Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

18:16 | Neural Dust

18:41 | Wireless magnetothermal deep brain stimulation

19:05 | Neural Stimulation Through Ultrasound

19:20 | Methods and Modalities: Sculpting Light

21:35 | Recent advances in patterned photostimulation for optogenetics

22:50 | Two-photon microscopy is now over 30 years old (Denk 1990)

25:22 | Optical Recording State of the Art

27:06 | Challenges of Deep Tissue 2-Photon Imaging

28:21 | Deisseroth Lab

28:29 | Temporal Precision of Optical Stimulation

29:09 | Simultaneous all-optical manipulation and recording 

30:40 | Targeted Ablation in Somatosensory Cortex 

33:29 | Commercially Available Fast Opsins

34:41 | Recent paper from Deisseroth Lab

41:17 | Cortical layer–specific critical dynamics triggering perception

42:21 | The Utah Array from Blackrock Neurotech

44:52 | Principles of Corticocortical Communication

50:43 | The Cost of Cortical Computation

51:27 | Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex (2013) | Spatiotemporal convergence and divergence in the rat S1 "barrel" cortex (1987) | Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice (2019) 

52:56 | Gollisch and Meister 2008

53:22 | Spike Timing-Dependent Plasticity (STDP)

1:05:09 | Neurotech Pub Episode 11 -  Let There Be Light

1:05:20 | Forecasting the Future

1:05:41 | Temporally precise single-cell-resolution optogenetics

1:06:16 | Large Scale Ca++ Recordings from Vaziri Lab

1:07:11 | Cohen Lab

1:07:19 | All Optical Electrophysiology 

1:14:19 | Emiliani et al 2015

1:16:33 | All-Optical Interrogation of Neural Circuits

1:16:53 | Mice Strains @ Jackson Lab

1:17:00 | The Allen Institute

1:20:39 | Neuroscience and Engineering Collaborations

1:18:39 | Nicolas Pegard

1:18:47 | Adesnik Lab

1:24:41 | Shenoy, Sahani, and Churchland 2013

1:24:52 | Dimensionality reduction for large-scale neural recordings

1:25:17 | Matlab: Understanding Kalman Filters

1:25:58 | Two-photon excitation microscopy

1:26:37 | Emiliani Lab Holography course

1:26:57 | Optics by Eugene Hecht

1:28:05 | Intro to Optics Course

1:29:41 | What the Heck Is a Claustrum?

1:33:53 | Cortical activity in the null space: permitting preparation without movement

1:34:33 | Neural Manifolds and Learning

1:35:19 | Locked-in Syndrome

1:36:58 | Sabatini Lab

1:37:07 | Probing and regulating dysfunctional circuits using DBS

1:39:36 | Sliman Bensmaia | Nicho Hatsopoulos

1:39:43 | The science and engineering behind sensitized brain-controlled bionic hands

1:41:20 | Michael Long's singing rodents

1:42:12 | Engram

1:43:06 | Chang Lab

1:43:19 | Tim Gardner | Michale Fee

Want more? 

Follow Paradromics & Neurotech Pub on Twitter  

Follow Matt A, Ian, Adam, & Matt K on Twitter

Welcome back to Neurotech Pub!

This episode is one of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD,  Mark Schnitzer, PhD, and Jacob Robinson, PhD. So far, our technical dives have focused mainly on direct electrical recording and stimulation of neural activity, but in this episode we deep dive into advantages that all-optical interfaces might have over electrical interfaces, and the challenges in developing them. 

In addition, we talk about running highly collaborative, interdisciplinary projects that span traditional physics and engineering with biology, a theme that is ever-present in neurotech and is also highlighted in part two of this series. 

Cheers!

Check out full video with transcript here: https://www.paradromics.com/podcast/episode-11-let-there-be-light

Show Notes

Latest news & publications since recording: 

>> Hillman Lab: New publication on SCAPE in Nature Biomedical Engineering

>> Robinson Lab: Review article in Optica on Recent advances in lensless imaging

>> Robinson Lab: BioRxiv pre-print on in vivo fluorescence imaging

1:23 | The Heart and Soul of a Paper

2:32| Ultrasmall Mode Volumes in Dielectric Optical Microcavities

3:01 | Robinson Lab

4:01 | Hillman Lab

4:07 | Zuckerman Institute

4:15 | Schnitzer Lab

4:25 | Howard Hughes Medical Institute

4:41| Miniature Fluorescence Microscope

9:02 | Discovery of DNA Structure and Function

10:25 | Hodgkin–Huxley Equations

13:49 | Vessel Dilation in the Brain

16:03 | State of the art of Neural Optical Recording

18:03 | Long-Term Optical Access to an Estimated One Million Neurons in Mouse Cortex

24:56 | Watch the Crystal Skull video

27:45 | High-Speed Cellular-Resolution Light Beads Microscopy

29:54 | Relationship between spiking activity and calcium imaging

32:50 | Analytical & Quantitative Light Microscopy [AQLM]

32:59 | Imaging Structure & Function in the Nervous System

35:22 | NIH Brain Initiative Cell Census Network (BICCN)

35:54 | Allen Brain Atlas: Cell Types

40:17 | A Theory of Multineuronal Dimensionality, Dynamics and Measurement

46:19 | Dr. Laura Waller's DIY Diffuser Cam

50:38 | FlatCam by Robinson Lab

53:42 | Advantages of MEG

55:06| Random Access Two Photon Scanning Techniques

56:07 | Swept Confocally-Aligned Planar Excitation (SCAPE)

58:47 | Optics Systems for Implantable BCIs

1:00:43 | GCaMP - Janelia GECI reagents

1:01:33 | DARPA NESD Program

1:04:06 | SCAPE Microscopy for High-Speed Volumetric Imaging of Behaving Organisms

1:07:00 | Glial Response to Implanted Electrodes

1:07:07 | Brain Tissue Responses to Neural Implants

1:09:36 | Two Deaths in Gene Therapy Trial for Rare Muscle Disease

1:10:46 | Intrinsic Optical Signal due to Blood Oxygenation

1:11:11 | Coupling Mechanism and Significance of the BOLD Signal

1:12:10 | DARPA invests in Treating Mood Disorders

1:12:57 | Amygdalar Representations of Pain

1:13:48 | Fast Optical Signals: Principles, Methods, and Experimental Results

1:14:12 | Dr. Larry Cohen's early work in Neurophotonics

1:14:42 | Linear Systems Analysis of Functional Magnetic Resonance Imaging | Additional Resource

1:16:20 | Flavoprotein Fluorescence Imaging in Neonates | Additional Resource

1:18:02 | Pumped Probe Microscopy

1:19:26 | Biological Imaging of Chemical Bonds by Stimulated Raman Scattering Microscopy

1:19:36 | Coherent Anti-Stokes Raman Scattering microscopy (CARS)

1:19:55 | Min Lab @ Columbia

1:20:06 | Glucose Analog for Stimulated Raman Scattering

1:20:39 | Emerging Paradigms for Aspiring Neurotechnologists

Want more? 

Follow Paradromics & Neurotech Pub on Twitter  

Follow Matt, Elizabeth, Jacob & Mark