Courage Over Convention

Never Conventional: Goat Milk, Psychedelics, and Beef Stew

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I recorded this jam early in '22 with my friend Stewart Alsop III. His podcast is called Crazy Wisdom...and you should subscribe to it.

Episode Covers (Among Other Things):

  • The current state of psychedelics as they pertain to medical uses, the efficacy of these treatments, and the political and economic pressures surrounding all of this. 
  • The most likely path to domestic adoption of medical psychedelic usage.
  • The marvels and potential dangers of iboga.
  • Nixon
  • Stewart's trippy, awesome business idea.
  • The human cost of PTSD running rampant.
  • The societal cost of it.
  • A shocking number of non-veterans suffer from complex PTSD in the US.
  • Inflation and used car purchase strategy.
  • Luna, Ethereum, crypto adoption among investment pros.
  • Lots of laughs and good times.

    • Side Note from Conversation at the 5-minute, 10-second mark:

    • The MAPS study is a Phase 3 clinical trial that assesses the safety and efficacy of MDMA-assisted therapy in treating severe posttraumatic stress disorder (PTSD) in adults. The trial is randomized, double-blind, placebo-controlled, and multi-site. The FDA has granted Breakthrough Therapy Designation to MDMA for the treatment of PTSD and is working closely with MAPS to provide guidance on the development of MDMA for PTSD. MAPS and FDA have also reached an agreement on the Special Protocol Assessment for Phase 3 clinical trials. The trials will provide evidence to support regulatory approval by the FDA.
    • Regarding Stewart's mention of the company creating a non-psychoactive medicine with ibogaine (I believe he was referring to Mind Medicine) - here is an excerpt from a great article (https://time.com/5951772/ibogaine-drug-treatment-addiction/) from Time:

      • More Americans died from drug overdoses last year than ever before, aggravated by the COVID-19 pandemic. Weekly counts of drug overdoses were up to 45% higher in 2020 than in the same periods in 2019, according to the U.S. Centers for Disease Control and Prevention published in February. Available treatments can’t meet the need.

      I was wrong at the 10:19 mark:

      • It was not MDMA and psilocybin being studied in the 50s and 60s - it was just psilocybin. A good article is linked below. Here is an excerpt: 

        • Researchers in the 1950s and 1960s studied the use of psychedelic-assisted therapy for the treatment of addictions such as alcohol dependence, some key findings of which were recently reviewed in a meta-analysis that suggested a significant beneficial effect. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592297/#:~:text=Researchers%20in%20the%201950s%20and,suggested%20a%20significant%20beneficial%20effect.)

        My favorite insight from Stewart:

        • "most people should probably not be taking iboga because it is terrifying - but if you have a kind of intuition that what you currently see is not reality, but a mirage on top of something that is at least related to reality...then this one can help you ask the right questions..."
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          Courage Over ConventionBy Woody Wiegmann
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