This episode reviews the Endocrine Society’s 2025 guideline updates on managing primary aldosteronism after initial screening.

• When suppression testing is indicated or unnecessary

• Cortisol cosecretion in adrenal adenomas and surgical planning

• Role of adrenal vein sampling (AVS) in determining laterality, with rare exceptions

• Treatment strategies for unilateral vs bilateral disease

• MRA therapy, titration approach, and importance of renin response