We review the history of syphilis, current trends, evaluation and treatment of pregnant women with syphilis and their newborns. We are joined by Muraleedharan Sivarajan, MD, Assistant Professor of Neonatal-Perinatal Medicine at the University of Texas Southwestern Medical Center.

We discuss the types of maternal and neonatal HSV infection, strategies for risk reduction, and evaluation of infants born to mothers with HSV. We are joined by Chelsea Anderson, MD, MHS, Assistant Professor of Neonatal-Perinatal Medicine at the University of Texas Southwestern Medical Center.

We learn about the history of reduction of mother-to-child transmission of HIV, and current recommendations for evaluation and management of the newborn. We are joined by Amanda Evans, MD, Assistant Professor of Pediatric Infectious Disease at the University of Texas Southwestern Medical Center.

We review the manifestations of the SARS-CoV-2 virus in newborns. We are joined by Kikelomo Babata, MD, Assistant Professor of Neonatal-Perinatal Medicine at the University of Texas Southwestern Medical Center.

We discuss potential complications and postnatal management of infants born to mothers with SARS-CoV-2 infection. We are joined by Kikelomo Babata, MD, Assistant Professor of Neonatal-Perinatal Medicine at the University of Texas Southwestern Medical Center.

We review the causative enzyme defects, presentation, evaluation, and prognosis for neonates with congenital adrenal hyperplasia. We are joined by Ming Yang, MD, Assistant Professor of Pediatric Endocrinology at the University of Texas Southwestern Medical Center.

We discuss the pathophysiology, presentation, and management of congenital hypothyroidism. We are joined by Soumya Adhikari, MD, Associate Professor of Pediatric Endocrinology at the University of Texas Southwestern Medical Center.

We review common genetic tests available for diagnosis of chromosomal anomalies: karyotype, FISH, and microarray. We are joined by Angela Scheuerle, MD, Professor of Pediatric Genetics at the University of Texas Southwestern Medical Center.

We discuss triaging which newborn metabolic disorders require more urgent assessment, acute and long-term management. We are joined by Luis Umaña, MD, Assistant Professor of Pediatric Genetics at the University of Texas Southwestern Medical Center.

We review classification and typical manifestations of the various inborn errors of metabolism. We are joined by Luis Umaña, MD, Assistant Professor of Pediatric Genetics at the University of Texas Southwestern Medical Center.