Get ready for NFL Week 1 best bets, teasers, and expert picks with Pat Mayo, Rob Pizzola, and Cam Stewart. We break down the full 2025 NFL Week 1 slate, with betting analysis, game previews, and our favorite teaser plays. Whether you’re looking for sharp betting edges, insights on key matchups, or value picks, this Week 1 betting guide has you covered.

Like & Subscribe + Drop your and drop your Week 1 picks in the comments to get in a draw for $250 CASH!!!!

FREE WEEK + 25% OFF NFL BETTING TOOLS & PACKAGES at https://www.4for4.com/mayo

$500K NFL Survivor ($50 Per Entry): https://bit.ly/mayo-survivor

Use code “MAYO” at underdog and make a $5 Pick’em entry and instantly get $50 in your account

Get a Deposit BONUS Coolbet: https://shorturl.at/CHfyW

 

Subscribe, Rate and Review

Apple: http://bit.ly/PMEiTunes

Spotify: https://goo.gl/VboemH

#UDPartner

 

JOHNNIE WALKER — To claim a customized Blue Label Sunday Golf Bag by Devereux Go to johnniewalker.com/blue-in-water

BETTERHELP — Visit BetterHelp.com/PATMAYO today to get 10% off your first month.

CHUBBIES — Your new wardrobe awaits! Get $10 off @chubbies with the code MAYO at https://www.chubbiesshorts.com/MAYO #chubbiespod

 

FOLLOW MAYO MEDIA NETWORK

Newsletter: https://mayomedia.substack.com/

Instagram: https://www.instagram.com/mayomedianetwork/

TIK TOK: https://www.tiktok.com/discover/mayo-media-network

YOUTUBE: https://bit.ly/YTMMN

 

Show Index

00:00 Intro

2:05 Survivor/Different Pools

21:03 Gold Picks

32:41 Silver Picks

51:13 Bronze Picks

1:00:22 Extra Games

1:06:03 Teaser Picks

 

Message and data rates apply. Must be 18+ (21+MA & AZ, 19+ AL, NE) and present in a state where Underdog Fantasy operates. Terms apply. Concerned with your play? Call 1-800-GAMBLER or visit www.ncpgambling.org; AZ: 1-800-NEXT-STEP (1-800-639-8783) or text NEXT-STEP to 53342; NY: Call the 24/7 HOPEline at 1-877-8-HOPENY or Text HOPENY (467369)

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.