Researchers at the University of North Carolina at Chapel Hill Superfund Research Program (UNC SRP) Center have identified metabolites in umbilical cord blood that are associated with exposure to arsenic in the womb. The findings also show that differences in a mother’s metabolism of arsenic may influence the metabolite profile of her baby. Assessing changes in the newborn’s metabolite profile by looking at the full range of metabolites, or metabolome, may provide insight into how prenatal arsenic exposure could affect important pathways responsible for maintaining normal cell processes in the body.

Exposure to a mixture of polycyclic aromatic hydrocarbons (PAHs) may produce different neurodevelopmental effects from those of exposure to individual PAHs, and the developing brain may be sensitive to these contaminants over a wide window of development, according to a Duke University Superfund Research Program (SRP) Center study.

A second-stage treatment using low levels of surfactants, which are commonly used as dispersing agents, may be a promising method to maximize removal of polycyclic aromatic hydrocarbons (PAHs) at hazardous waste sites, according to findings from the University of North Carolina at Chapel Hill Superfund Research Program (UNC SRP) Center. Researchers identified specific surfactants that enhanced the removal of PAHs from previously treated soil by making the chemicals more accessible for degradation by bacteria.

Killifish living in four polluted East Coast estuaries have adapted quickly to survive high levels of toxic industrial pollutants. In a new study, researchers explored the complex genetics involved in the Atlantic killifish's resilience, bringing us one step closer to understanding how they rapidly evolved to tolerate normally lethal levels of environmental contaminants. Exploring the evolutionary basis for these genetic changes may provide new information about the mechanisms of environmental chemical toxicity in both animals and humans.

Killifish living in four polluted East Coast estuaries have adapted quickly to survive high levels of toxic industrial pollutants. In a new study, researchers explored the complex genetics involved in the Atlantic killifish’s resilience, bringing us one step closer to understanding how they rapidly evolved to tolerate normally lethal levels of environmental contaminants. Exploring the evolutionary basis for these genetic changes may provide new information about the mechanisms of environmental chemical toxicity in both animals and humans.

A new tool and accompanying method provides an easy way to extract substances from urine, even where resources are limited. The non-targeted technique, developed by researchers at the Northeastern University Superfund Research Program, can reveal large numbers of exposures to substances foreign to the body, called xenobiotics, from a sample of urine.

Researchers at the University of Kentucky Superfund Research Program (UK SRP) Center have identified a new mechanism linking exposure to polychlorinated biphenyls (PCBs) and cardiovascular disease (CVD). They revealed that PCBs can lead to increased production of a biological marker of CVD, which is also linked to consumption of red meat and other animal products, revealing a novel diet-toxicant interaction associated with CVD risk.

The aryl hydrocarbon receptor (AhR) plays an important role in oral cancer, and environmental chemicals and bacteria that activate the AhR may worsen oral cancer development and progression, according to a recent study from the Boston University Superfund Research Program (SRP) Center.

Carbon from relatively new sources of organic material on the surface, or young carbon, can stimulate microbial communities deep in aquifers, leading to the release of arsenic into water, according to a recent field study by Columbia University Superfund Research Program (SRP) Center researchers. The researchers found that near-surface sources of organic carbon are central in microbial metabolism, even in aquifers that are far below and separated from the land where carbon is derived.

Superfund Research Program (SRP) researchers at the University of California, San Diego (UCSD) are identifying important mechanisms that plants use to respond to changes in the environment. They recently discovered molecular mechanisms that enhance the activity of proteins essential to closing stomata, or pores found on the surface of leaves, in response to environmental stressors.