The Longevity Show with Dr. Hillary Lin

“Normal” Labs but Still Exhausted? Mitochondrial Series (Pt 1): Mitophagy + 4-Step Protocol


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If you’re sleeping well, eating clean, exercising—and still exhausted—this may be an engine problem, not a fuel problem.This is Part 1 of my Mitochondrial Health Series, where I start with the foundation: mitophagy—your body’s ability to clear damaged mitochondria.In longevity medicine, I call this mitophagy failure: damaged mitochondria (“zombie batteries”) stop producing clean energy and leak signals that can trigger inflammation, brain fog, and that 2 p.m. crash.In this video, I break down:• Why zombie mitochondria can keep you stuck in “sickness behavior”• The key biology: PINK1 + Parkin (how your cells tag and remove broken mitochondria)• My 4-step energy protocol: 14–16 hr overnight fasting, Zone 2 cardio, heat (sauna/hot bath), and urolithin A + spermidine• The NAD+ trap: why NMN/NR can backfire if you “fuel” before you “clean”Chapters:

00:00 The "Zombie Battery" Cause of Fatigue

01:54 Why Your Cells Think They Are Dying04:43 The Cleanup Crew: PINK1 & Parkin07:02 Protocol 1: The "Janitor" Fast (AMPK vs. mTOR)08:44 Protocol 2: Why HIIT Might Be Making You Tired09:59 Protocol 3: Heat Shock Proteins & Sauna11:30 Protocol 4: Supplements (Urolithin A, Spermidine) & The NAD+ Mistake15:18 Summary: The 4-Step Energy Protocol

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The Longevity Show with Dr. Hillary LinBy Hillary Lin, MD