You probably track your sleep, HRV, and blood work, yet the second-largest microbiome in your body is quietly driving systemic aging. In fact, 57 major systemic diseases—including Alzheimer's, cardiovascular disease, and autoimmune conditions—are directly linked to oral inflammation.

Traditional dentistry waits for symptoms—cavities, bleeding gums, or severe pain—before treating the problem. Dr. Jonathan Levine argues this is like waiting for a massive heart attack before ever checking your cholesterol.

In this episode, we dismantle the 1840 "Grand Rebuke" that dangerously separated dentistry from medicine. We explain why standard basic cleanings fail to detect early pathogenic risk and why the equivalent of a preventative full-body scan for your mouth—AI-enabled 3D Mouth Mapping—is the only way to truly visualize your risk. We also dive deep into advanced longevity protocols, including airway expansion for deep sleep, point-of-care salivary omics, and the high-performance oral hygiene regimen you need to adopt immediately.

Topics Covered:

• The Failure of the "Gold Standard": Why standard 2D x-rays and basic cleanings completely miss dangerous pathogens.

• Leaky Gums & Systemic Disease: Understanding how the P. gingivalis bacteria travels from your mouth to build arterial plaque and drive Alzheimer's.

• Advanced Imaging: How 3D Mouth Mapping and AI visualize hidden airway obstructions and structural breakdown.

• Protocols for Prevention: The role of pH-raising rinses, tongue scraping, and why you must throw out alcohol-based mouthwashes.

• Airway Health & Sleep: The connection between mouth breathing, nitric oxide depletion, and how structural jaw expansion can cure disrupted sleep.

• The Nuance of Fluoride: Protecting your enamel without neurotoxic risks through dose-specific applications.

About Dr. Jonathan Levine:

Dr. Jonathan Levine is a preventative prosthodontist, clinical innovator, and pioneer in oral-systemic health based in New York City. He is the inventor of GLO Science technology and the co-founder of Smile House, the Center for Dental Longevity. He has dedicated his 35-year career to bridging the gap between medicine and dentistry, utilizing advanced diagnostics to detect and stop systemic inflammatory diseases at their source.

Website: https://www.drjonathanlevine.com/

Instagram:   / drjonlevine  

JBL New York City: @jblnewyorkcity

Smile House Tribeca: @smilehousetribeca

GLO Science: @gloscience

GLO Science Pro: @glosciencepro

GLO Good Foundation: @glogoodfoundation

Chapters

00:00 The Overlooked Role of Oral Health in Longevity

03:10 Rebuilding the Dental Care Model

06:19 The Center for Dental Longevity & Smile House

11:14 The Oral-Systemic Connection

14:33 Integrating Dentistry with Overall Health

20:07 The Tech-Enabled Dental Exam

22:28 Airway Health, Nitric Oxide, & Sleep

29:51 The Future of Salivary Diagnostics

31:12 Mission Work in Dental Deserts

34:06 High-Performance Oral Protocols

36:48 The Role of Fluoride in Dental Health

39:17 Epigenetics vs. Genetics in Decay

46:04 Top Takeaways for Oral Longevity

50% of people who die of a heart attack have zero prior symptoms. They have no chest pain, no shortness of breath, and often, "normal" cholesterol on a standard panel.

In Part 1 of 𝘛𝘩𝘦 𝘔𝘰𝘥𝘦𝘳𝘯 𝘓𝘪𝘱𝘪𝘥 𝘗𝘭𝘢𝘺𝘣𝘰𝘰𝘬, I break down why the standard of care is failing to detect the world's #1 killer until it’s too late. I share the science on why atherosclerosis is actually a pediatric disease, the "cumulative exposure" math that proves early prevention is 3x more effective, and the specific blood markers you need to look at instead of just LDL-C.

📩 𝐆𝐞𝐭 𝐖𝐞𝐞𝐤𝐥𝐲 𝐋𝐨𝐧𝐠𝐞𝐯𝐢𝐭𝐲 𝐔𝐩𝐝𝐚𝐭𝐞𝐬:

https://www.hillarylinmd.com/subscribe

𝐎𝐍 𝐓𝐇𝐈𝐒 𝐄𝐏𝐈𝐒𝐎𝐃𝐄:

We dismantle the "plumbing" model of heart disease and replace it with the latest science on lipidology and longevity.

• 𝐓𝐡𝐞 "𝐒𝐢𝐥𝐞𝐧𝐭" 𝐊𝐢𝐥𝐥𝐞𝐫: Why your body is evolutionarily designed to hide heart disease from you.

• 𝐓𝐡𝐞 𝐏𝐞𝐝𝐢𝐚𝐭𝐫𝐢𝐜 𝐄𝐯𝐢𝐝𝐞𝐧𝐜𝐞: Autopsy data showing plaque in 20-year-olds (Korean War & PDAY studies).

• 𝐓𝐡𝐞 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦: How ApoB particles get trapped in the artery wall (The "Response to Retention" model).

• 𝐓𝐡𝐞 𝐌𝐚𝐭𝐡 𝐨𝐟 𝐑𝐢𝐬𝐤: Why "Cholesterol-Years" matter more than your current numbers.

• 𝐋𝐢𝐟𝐞𝐬𝐭𝐲𝐥𝐞 𝐅𝐚𝐜𝐭𝐨𝐫𝐬: How sleep debt and stress physically damage your endothelium.

𝐂𝐇𝐀𝐏𝐓𝐄𝐑𝐒:

01:47 One Disease, Three Addresses: Heart Attack, Stroke, and Aneurysm

03:09 The Pediatric Bombshell: This Is a Childhood Disease

09:14 The Mechanism: What's Actually Happening Inside Your Arteries

15:20 The Math of Cumulative Exposure: Why When You Start Matters More Than What You Do

22:17 The Evolutionary Paradox: Why Our Bodies Betray Us

27:41 The Invisible Damage: What's Happening While You Feel Fine

32:27 The Information War: Why You’re Confused

41:12 What This Means For You: The Stakes, The Opportunity

We’ve been told the same story for 50 years: "Saturated fat is bad, vegetable oil is heart-healthy." But if that’s true, why are we in a global energy crisis of chronic fatigue and metabolic stalling?

As a longevity physician, I look at the body like an engineer looks at a high-performance machine. When the engine stalls, I don't blame the driver—I look at the fuel. In this masterclass, we dismantle the "Fat Wars" with clinical nuance. I explain why the Seed Oil debate is often missing the most dangerous variable: Oxidation. We explore the "Two-Hit Theory" of heart disease, how unstable fats create "zombie" membranes in your mitochondria, and why your Air Fryer might be an oxidation accelerator. Most importantly, I provide a practical kitchen protocol to help you rebuild your biology from the cell membrane out.

In this episode, we cover:

• The Two-Hit Theory: Why LDL volume is only half the problem (and why oxidation is the match that lights the fire).

• The Membrane Theory: How Linoleic Acid creates "fragile" cells that leak toxic waste (4-HNE) into your brain.

• The Migraine Connection: New NIH data on how specific oils chemically activate your pain receptors (TRPV1).

• The Smoke Point Lie: Why "high smoke point" oils can still rot your DNA.

• The Official Protocol: My Tier 1, 2, and 3 hierarchy for the longevity-focused kitchen.

Chapters

00:00 The Energy Crisis Within Us

01:47 The Two-Hit Theory: Why "Healthy" Oils May Be Driving Heart Disease

04:34 Cellular Sabotage: How Unstable Fats Break Mitochondria & Trigger Pain

07:54 Cooking Myths Debunked: Smoke Points, Olive Oil, & Air Fryer Risks

09:50 The Return of Solid Fats: Why Tallow Wins & Crisco Kills

11:37 The Official Protocol: Tier 1, 2, and 3 Oils for Your Kitchen

✨ Get 5 Easy Longevity Tips & Dr. Hillary Lin's Weekly Newsletter for Free: https://www.hillarylinmd.com/subscribe

About the Show:

The Longevity Show with Dr. Hillary Lin takes complex medical research and distills it into practical, easy-to-understand advice for living a longer, healthier life. Covering everything from preventative medicine and metabolic health to the latest breakthroughs in nutrition, exercise, and mental wellness, Dr. Lin gives you the tools you need to thrive.

About Dr. Hillary Lin and Care Core

Dr. Hillary Lin is a Stanford MD and CEO/Co-founder of Care Core, a platform helping clinicians launch personalized longevity practices powered by evidence-based protocols and AI-driven tools. Follow for insights on transforming care delivery through precision medicine.

Connect with Dr. Hillary Lin:

Instagram: https://www.instagram.com/hillarylinmd Facebook: https://www.facebook.com/hillarylinmd X: https://twitter.com/hillarylinmd TikTok: https://www.tiktok.com/@hillarylinmd

Disclaimer:

This podcast is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. No doctor-patient relationship is formed. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Use of this information is at your own risk.

If you’re sleeping well, eating clean, exercising—and still exhausted—this may be an engine problem, not a fuel problem.This is Part 1 of my Mitochondrial Health Series, where I start with the foundation: mitophagy—your body’s ability to clear damaged mitochondria.In longevity medicine, I call this mitophagy failure: damaged mitochondria (“zombie batteries”) stop producing clean energy and leak signals that can trigger inflammation, brain fog, and that 2 p.m. crash.In this video, I break down:• Why zombie mitochondria can keep you stuck in “sickness behavior”• The key biology: PINK1 + Parkin (how your cells tag and remove broken mitochondria)• My 4-step energy protocol: 14–16 hr overnight fasting, Zone 2 cardio, heat (sauna/hot bath), and urolithin A + spermidine• The NAD+ trap: why NMN/NR can backfire if you “fuel” before you “clean”Chapters:

00:00 The "Zombie Battery" Cause of Fatigue

01:54 Why Your Cells Think They Are Dying04:43 The Cleanup Crew: PINK1 & Parkin07:02 Protocol 1: The "Janitor" Fast (AMPK vs. mTOR)08:44 Protocol 2: Why HIIT Might Be Making You Tired09:59 Protocol 3: Heat Shock Proteins & Sauna11:30 Protocol 4: Supplements (Urolithin A, Spermidine) & The NAD+ Mistake15:18 Summary: The 4-Step Energy Protocol

Heart disease is still the #1 killer worldwide, yet 50-75% of people who suffer a heart attack have "normal" cholesterol levels.Traditional cardiology waits for symptoms—chest pain, shortness of breath, or cardiac arrest—before treating the problem. Dr. John Osborne, MD, PhD, argues this is like waiting for Stage 4 cancer before ordering a screening.In this episode, we dismantle "20th Century Cardiology." We explain why standard EKGs and stress tests fail to detect early plaque and why the "Cardiac Colonoscopy"—AI-enabled CCTA—is the only way to truly visualize your risk. We also dive deep into advanced reversal protocols, including the use of Colchicine for inflammation, the "Keto Paradox," and the genetic biomarkers (Lp(a) and ApoB) that you need to request immediately.*Topics Covered:*• The Failure of "Gold Standards": Why stress tests miss 30-40% of dangerous blockages.• Soft Plaque vs. Hard Plaque: Understanding the difference between stable calcium and the "lava" that causes sudden death.• Advanced Imaging: How AI CCTA visualizes the vessel wall (the "donut") rather than just the hole.• Protocols for Reversal: The role of Colchicine, PCSK9 inhibitors, and statins in shrinking plaque.• The Keto Paradox: Can you have healthy arteries with high cholesterol?• Genetics: Why everyone needs to test for Lipoprotein(a) once in their life.About Dr. John Osborne:Dr. John Osborne is a Preventative Cardiologist and Lipidologist based in Dallas. He holds an MD and PhD in cardiovascular physiology and founded State of the Heart Cardiology. He is the Co-Founder and Chief Medical Officer of Clear Cardio, pioneering the use of AI in cardiac imaging to detect and reverse heart disease before it becomes fatal.

Chapters:

00:00 Introduction to Heart Disease and Its Impact

04:46 Why Your "Normal" Cardiology Workup Is Useless

13:08 The Cardiac Colonoscopy: AI Imaging vs. Blind Blood Work

16:24 Cardiac CT + AI: The 20-Second Scan That Changes Everything

31:08 The Blood Tests That Actually Matter

36:36 Cholesterol vs. Sticky Vessels: The Two-Factor Model 

40:45 The Debate on Diets: Cholesterol and Inflammation

44:13 Reversing Heart Disease: Colchicine, Statins, and New Protocols

54:14 Exploring Stem Cell Therapy in Cardiology

57:00 The Future of Preventative Cardiology

When most people imagine living to 100, they don’t picture joy, movement, or independence. They picture decline. Years spent in medical offices. A body that can’t keep up with the life they still want to live.That reaction reveals something important. The real problem isn’t how long we live. It’s how well we live those added years.In this episode, we explore the gap between lifespan (how long you live) and healthspan (how long you live well), and why so many people spend the last decade or two of life surviving instead of thriving. You’ll see why this gap exists, how modern healthcare and society make it worse, and what can be done to change the trajectory.Here’s what we cover:⭐ Why the healthspan–lifespan gap exists⭐ The forces inside the healthcare system that work against prevention⭐ Societal pressures that quietly undermine long-term health⭐ The biological wiring that makes healthy choices harder than they should be⭐ Practical steps to help close the gapFor anyone who has seen a parent or grandparent lose their independence too early, or anyone who wants their later decades to be full of movement, purpose, and connection, this conversation matters.“In the end, it’s not the years in your life that count. It’s the life in your years.”If this episode helps reframe what aging can look like, tap like, share your biggest insight in the comments, and send it to someone you want to grow old well with.

Chapters

01:28 Why the Healthspan-Lifespan Gap Exists05:06 Economic and Systemic Barriers to Healthspan10:49 Societal Barriers to Healthspan Extension14:00 Biological Barriers to Healthspan Extension

20% of the population has high Lipoprotein(a), yet most doctors don't test for it until it’s too late. Lp(a) is an independent genetic risk factor that triples your risk of heart attack and stroke. If you've never had this specific blood test, this video is a must-watch. I explain exactly what it is and how to ask for the test.In this episode, we cover what Lp(a) is, why it is strongly inherited, and which groups are most affected. You will learn how to test for it, what levels mean, and why new RNA based treatments could change cardiovascular care in the next few years. If you have a family history of heart disease or “normal” cholesterol with lingering symptoms, this is essential viewing.What you will learn:• Why Lp(a) is missed on standard cholesterol tests• How genetics set your Lp(a) level for life• Ethnic differences in Lp(a) and who should test today• Why Lp(a) promotes plaque, inflammation, and clots• Current options. PCSK9 inhibitors, apheresis, and lifestyle strategy• New RNA based therapies that may drop Lp(a) by up to 90 percentIf heart disease runs in your family, ask your clinician for an Lp(a) test. This one number can change your prevention plan.#lipoproteina #lpa #cholesterol #heartdisease #strokeprevention #cardiovascularhealth #heartattack #cardiologist #cholesteroltest #preventivemedicine #genetics #atherosclerosis #pcsk9 #rnatherapy #hillarylinmd

What if your biggest risk isn’t food or fitness. It’s the tumor or aneurysm no one is looking for. Dr. Alan Alexander shows how a 30-minute whole-body MRI is already saving lives.

Former team physician for the Lakers and Dodgers. NIH longevity researcher. Now CEO of CoreViva. Dr. Alexander explains why proactive imaging matters, how thin-slice MRI can find early cancers and aneurysms, and why “know your body” beats waiting for symptoms. We also dig into caloric restriction, intermittent fasting done right, the 3-2-1 sleep rule, tech-neck epidemic, pricing and insurance realities, and a bold 2035 vision for preventive care.
Key takeaways:• Why standard screening leaves gaps. What MRI can catch across organs• Intermittent fasting works when calories actually drop. Not when you cram meals• The 3-2-1 sleep rule for better melatonin release• Tech-neck is everywhere. Here is what thin-slice imaging reveals• Immediate results with physician consult. Then a detailed report and CoreViva Score• Pricing, false positives, and when insurance could follow the data• How proactive care shifts outcomes and cost curves by 2035

Chapters

00:57 What Caloric Restriction Taught Us About Aging07:57 How Elite Athletes Master Longevity Habits10:25 How CoreViva Was Created to Save Lives12:59 Inside A CoreViva Scan: What Patients Experience16:32 What the Scans Are Revealing About Modern Health25:23 The Future of Prevention and Longevity Medicine39:17 The 3 Habits That Outlive Us All
#WholeBodyMRI #EarlyCancerDetection #LongevityPodcast #PreventiveMedicine #ProactiveHealth #CoreViva #MRIScreening #BrainAneurysmScreening #VisceralFatMRI #MusculoskeletalAge #IntermittentFastingScience #CaloricRestrictionPrimate #BlueZonesLongevity #Sleep321Rule #TechNeck #AthleteLongevity #LakersDoctor #DodgersDoctor #AIinRadiology #AnnualHealthScreening #PreventiveImaging #CancerScreeningOptions #HillaryLinMD #CareCore

Could you be carrying years of toxic metal exposure in your body without knowing it?

This is Part 2 of our deep dive into heavy metal toxicity—a silent health threat linked to fatigue, brain fog, aging, and chronic disease.

In this episode, we reveal exactly how to test your body, interpret your results, and detox effectively using both natural remedies and advanced therapies.

🧬 What You’ll Learn in Part 2:

✅ The difference between blood, hair, and urine metal testing

✅ Food & supplement protocols for detox (zinc, magnesium, glutathione & more)

✅ Which “detox trends” are hype vs. scientifically proven

✅ Advanced options: chelation, nano-chelators, red light therapy & more

✅ How to protect your family, home & longevity from heavy metal exposure

📌 Symptoms we cover: fatigue, anxiety, insomnia, brain fog, premature aging, immune issues

📈 Heavy metals are everywhere—from water to cosmetics—and they're linked to serious health risks. But now you’ll know exactly what to do about it.

Chapters:

00:00 Introduction to Heavy Metals and Health Risks

00:49 What Are Heavy Metals and Why Should You Care?

01:58 How to Test for Heavy Metals in Your Body

08:38 Detox Strategies: Dietary Approaches

15:12 Detox Strategies: Lifestyle Adjustments

17:30 Heavy Metal Detox: Advanced Therapies and Emerging Tech

#HeavyMetalDetox #ToxicExposure #ChelationTherapy #MercuryPoisoning #LeadToxicity #BrainFogFix #FunctionalMedicine #FatigueRelief #WellnessTips #LongevityHack #NaturalHealing #HealthPodcast #DetoxNaturally #HowToDetox #Part2 #HillaryLinMD #HillaryLin #Longevity

Are you unknowingly absorbing toxins that sabotage your energy, memory, and lifespan?Over 50% of Americans carry toxic heavy metals—like lead, mercury, and arsenic—from everyday items like food, water, cosmetics, and cookware.In this must-watch episode, Dr. Hillary Lin, longevity physician, uncovers:✅ What heavy metals are doing to your brain, heart, and hormones✅ The shocking places they hide in your daily life✅ Proven, advanced detox strategies that actually work✅ Real patient stories (including hers) that may mirror your own health journey🧠 Tired of unexplained fatigue or brain fog? This might be the root cause.🎯 Learn how to reclaim your energy and protect your health today.🔔 Subscribe for weekly insights on longevity, biohacking, and science-backed health tips.Chapters:

00:00 Understanding Heavy Metal Toxicity02:17 How Heavy Metals Hurt Our Health09:11 Diseases Caused by Heavy Metals21:06 Sources of Heavy Metal Exposure29:42 Unusual Places Where Heavy Metals Are Hiding36:11 How to Reduce Heavy Metal Exposure in Everyday Life#HeavyMetals #Detox #Longevity #HealthTips #BrainFog #DrHillaryLin #Biohacking #FunctionalMedicine #ToxinFreeLife #ChronicFatigue #CleanLiving #HillaryLinMD #Science #Medicine #Medical #LongevityMedicine