Answers from the Lab

Novel biomarkers added to movement disorders profile: Andrew McKeon, M.B., B.Ch., M.D.


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(00:32)
 Can you tell our audience a little bit about yourself and your role here at Mayo Clinic?

(01:29)
 Can you tell our listeners a little bit about the disease state when we talk about autoimmune or paraneoplastic movement disorders?

(02:37)
 Are we seeing an increased prevalence of autoimmune movement disorders?

(04:00)
 Can you give our listeners an overview of what's going to be launched here in January?

(06:56)
 What other antibodies are particularly important in this phenotype?

(10:01)
 How does the kelch-like protein 11 phenotype manifest in this disorder?

(10:49)
 Are there any antibodies in the autoimmune neurology space that would not need to be evaluated for in patients that present with some sort of movement disorder? 

(11:18)
 Which patients should have this testing and when should it be performed?

(12:55)
 When should Mayo Clinic Laboratories' stiff person evaluation and standalone glycine receptor tests be used, and in what order?

(14:40)
 Is the movement disorder evaluation the right first choice when the patient presentation is less typical and includes ataxia?

(16:42)
 Can physicians order the glycine receptor standalone test to fully evaluate the spectrum of antibodies?

(18:39)
 How does the evaluation impact patient care?

(20:12)
 Have these new antibodies been shown to be immunotherapy-responsive?

(20:27)
 Is there a key takeaway with the launch of these new antibodies in the movement disorder evaluation?

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