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My Current Anti-Aging Protocol:

·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) 

·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) 

·      500mg Metformin

·      1.5 grams of TMG (https://bit.ly/3oe1Ted) 

·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) 

·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) 

·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) 

·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) 

·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) 

·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)

·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)

·      81mg of aspirin (https://bit.ly/3uFjtem) 

·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)

·      600mg DIM (https://bit.ly/3ZX9NsG)

·      800mg GlyNAC (https://shorturl.ac/7b75r)

Links:

https://pubmed.ncbi.nlm.nih.gov/31710095/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509089/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951182/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/

A long-term clinical study from Denmark has shown that increased Nicotinamide Adenine Dinucleotide (NAD) levels and improved mitochondrial function results from NR supplementation in mice could not unfortunately be repeated in humans.

NR 12 Week Study in Humans

Studies in animals have shown that NAD boosters stimulate metabolic health by improving mitochondrial function in skeletal muscle, so far NR supplementation has only been shown to raise human NAD levels in blood.

Scientists from Denmark have published, in the Journal of Physiology, the results of a 12-week study where they tested the effects of NR on NAD levels and mitochondrial function in human skeletal muscle.

Metabolic Health

Our metabolic health depends on mitochondrial function, but as our NAD decreases with age so does our mitochondrial function.

Research has linked these declines with age-related diseases such as obesity, insulin resistance and type 2 diabetes, this in turn results in the defective regulation of our skeletal muscle metabolism.

Scientific Study

The team of scientists studied NR supplementation to see if it did in fact increase NAD levels and improve mitochondrial function in human skeletal muscle too.

The clinical trial consisted of 40 participants (men with obesity and insulin resistance)

 They were given 1000 mg NR or a placebo twice a day for 12 weeks, 2000 mg per day is a lot, the advised dose is around 300 mg a day.

Results

The results showed that NR supplements did not improve NAD levels in the participants’ skeletal muscle.

The study also concluded that NR supplementation did not affect the level of mitochondria in their skeletal muscle.

The team also measured the levels of citrate synthase, an enzyme that correlates to mitochondrial levels, and unfortunately also found no changes.

The team also checked to see if NR supplementation increased reactions that use oxygen to convert nutrients into cellular energy, they found that NR supplementation did not increase in the overall mitochondrial oxidative capacity in human skeletal muscle

Study Conclusion

The team stated, ‘our data does not support the hypothesis that dietary NR supplementation has significant impact on skeletal muscle mitochondria in obese and insulin-resistant men.’

They also stated, ‘Future studies on the effects of NR on human skeletal muscle may include both sexes and potentially provide comparisons between younger and older people.’

The NR community

The NR community has been very quiet about this study? Charles Brenner who is usually very vocal (in his tweets) when it comes to the lack of NMN human studies or rubbishes anything linked to David Sinclair such as resveratrol, seems to have lost the ability to Tweet.

What the study doesn’t tell us

This study is very specific, if you are a man with obesity and insulin resistance, NR will not improve mitochondrial function in your skeletal muscle, IMHO anyone commenting on this study and not talking about the specifics of this study is just guessing.

 This study was conducted specifically in men with obesity and insulin resistance, so does NR work on skeletal muscle if:

You are a woman with obesity and insulin resistance

If you are obese, but not insulin resistant or vice versa

If you are neither obese nor insulin resistant

 There still seems to be more questions than answers and let’s hope that in the future that these type of studies are also conducted with NMN

and that they test people with other age related diseases, not just obesity and insulin resistance.

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