• Origin Stories and path to Biotech [00:00]
• Taking the leap to entrepreneurship [07:30]
• The formation story of Guardian Bio [20:25]
• The methodical process Ananya used to identify a co-founder [26:00]
• The core thesis of Guardian Bio- Dendritic Cells for Solid Tumors [29:00]
• The key pivots Guardian made early on [34:15]

[02:15] Bobby Gaspar’s background

[05:10] The science of haematopoietic stem cell therapy

[12:30] Spinning out Orchard Therapeutics

[21:15] Reverse partnerships with pharma

[25:55] Balancing regulatory compliance and innovation

[29:45] Value based payments 

[35:15] Recent approval of Casgevy and gene therapy regulation

[39:45] Failures in a biotech’s journey

[43:00] Impact and meaning in therapeutics companies

• Trevor talks about his inspirations for his career path [1:22]
• How to choose his PhD advisor and lab [3:51]
• Career trajectory, handling moments of uncertainty, and learning from mistakes [9:56]
• Trevor discovered a niche at the intersection of biology, physics, and computer science [11:54]
• Mammoth is uniquely positioned as an innovative science-focused company that delivers for patients [18:36]
• Trevor's key leadership advice he has learned as a CEO [24:43]
• CRISPR technology has the potential to revolutionize healthcare [27:55]

Show Notes

Tony's career foundations as an academic scientist at MIT and early inspiration for entrepreneurship  [0:43]

Engaging in entrepreneurial groups shaped Tony's early career [07:10]

Tony's inspiration to co-found Petri [11:38]

Pillar is rethinking the approach to biotech investing [25:21]

Pillar's investment thesis [30:34]

Tony's advice to a PhD student who is considering industry and entrepreneurship [35:59]

What sparked Dr. Goodman’s interest in biotech (0:00)

Deciding to pivot from academia to venture capital (3:45)

Failing fast and applying that mindset to science (9:44)

Transitioning from academia to a start up (14:44)

Advice for aspiring technical founders (20:03)

Becoming an investor at MPM Capital (30:24)

MPM’s investment thesis in oncology. (40:14)