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02:18 - Eric Kelsic's background in physics and systems biology and how it shaped his approach to biological problems

03:57 - Differences in problem-solving between Kelsic's physics/systems biology background and traditional biology backgrounds

06:27 - Learning from working with George Church and his lab's approach to fostering innovation

10:02 - George Church's openness to exploring ideas

12:02 - How Kelsic's experience in George Church's lab led him to start Dyno Therapeutics

19:55 - Kelsic's process of validating the problem of AAV gene delivery and deciding to found a company

24:36 - Leveraging resources like Harvard, the Wyss Institute, and Lab Central in Dyno's early days

28:17 - Overview of AAV gene therapy and Dyno's machine learning-guided approach to engineering improved capsids

38:17 - Kelsic's perspective on partnerships and Dyno's collaborations with industry leaders

41:02 - Kelsic's vision for the future of Dyno and the potential impact of gene therapy