The global epidemic of HIV/AIDS presents enormous challenges to the family, community, church, and health care workers. Equipping one another to prevent HIV transmission, reducing stigma and risky sexual behaviors and supporting all levels of the family and community to provide care is a calling for Christian nurses. This session will explore the realities of responding to that call across many nations and bring case studies from remote Papua, Indonesia as well as people-packed India. Best global practice in HIV interventions at the family, community, and clinic level is reviewed with careful Biblical thought and mandate. Discussion will stimulate consideration of your own life choices in light of this global opportunity to give life in it's fullest to many across our world. Themes and technical areas covered will include caring in the context of minimal resources, the biblical basis for caring about the AIDS crisis, understanding best practice in prevention, care, and support, and effective communication across cultures in health knowledge and care.