Host: John Buse, MD, PhD

Guest: Louis J. Aronne, MD, FTOS

In the SURMOUNT-4 trial, 100 patients with obesity were on tirezpatide for 9 months, and the average weight loss was 20.9 percent. The patients were then randomized to receive either placebo with behavioral intervention or tirzepatide for another year, and the patients in the former group regained a significant amount of weight. Dive further into the study’s findings and implications with Dr. John Buse and Dr. Louis Aronne, the Sanford I. Weill Professor of Metabolic Research at Weill Cornell Medical College in New York.

Host: Javed Butler, MD

Guest: Chiadi Ndumele, M.D., Ph.D., M.H.S.

For the first time, the American Heart Association (AHA) has identified cardiovascular-kidney-metabolic (CKM) syndrome, which reflects a strong overlap between heart disease, kidney disease, and obesity. The major clinical consequence of CKM syndrome is multi-organ dysfunction with a particularly high incidence and burden of cardiovascular disease (CVD), and the result of this is premature morbidity and mortality. So as a result, recognizing CKM syndrome is the first step in earlier diagnosis and treatment. Dive into this episode with Dr. Javed Butler who’s joined by Dr. Chiadi Ndumele, Associate Professor of Medicine and the Director of Obesity and Cardiometabolic Research at Johns Hopkins University.

Host: John Buse, MD, PhD

Guest: Jean-Philippe Drouin-Chartier, DtP, PhD

What’s the relationship between ultra-processed food consumption and the risk of developing type 2 diabetes? Find out with Dr. John Buse as he speaks with Dr. Jean-Philippe Drouin-Chartier about his research that sought to answer this exact question. Dr. Drouin-Chartier is an Assistant Professor at the Faculté de Pharmacie at Laval University and a researcher in the Nutrition, Health, and Society Center of the Institute on Nutrition and Functional Foods in Quebec, Canada.

Host: Peter Buch, MD, FACG, AGAF, FACP

Guest: Marianna Arvanitakis, MD, PhD

Patients with non-celiac gluten sensitivity can experience the same symptoms of those with celiac disease and IBS, complicating the diagnostic process. Find out how you can accurately identify and distinguish non-celiac gluten sensitivity from other digestive disorders with Dr. Peter Buch and Dr. Marianna Arvanitakis, Associate Clinical Professor in the Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology from the HUB Erasme Hospital in Brussels, Belgium.

Host: Charles Turck, PharmD, BCPS, BCCCP

Guest: Sorana Segal-Maurer, MD

Research has shown that those living with HIV are more likely to be malnourished and experience nutrient deficiencies that play an essential role in their immunity. In the early days of HIV, a typical recommendation was to increase a patient’s calorie count. To discuss how the focus on nutrition has changed now that this patient population is living much longer, Dr. Charles Turck is joined by Dr. Sorana Segal-Maurer, Director of Infectious Diseases at New York-Presbyterian Queens and Professor of Clinical Medicine at Weill Cornell Medicine in New York City.

Host: John Buse, MD, PhD

Guest: Karen D. Corbin, PhD, RD

One of the biggest missing links in current literature about obesity and the gut microbiome was causality. In an effort to address that gap, a recent clinical trial was conducted, and now, the results are in. So what were the key findings, and how can we translate those findings into clinical practice? Find out how one’s diet can affect the gut microbiome with Dr. John Buse and Dr. Karen Corbin, an Investigator at the AdventHealth Translational Research Institute in Orlando, Florida.

Host: Peter Buch, MD, FACG, AGAF, FACP

Guest: Marianna Arvanitakis, MD, PhD

Consuming ultra-processed foods can pose many risks to your health that go beyond the GI system. Explore the risks associated with ultra-processed foods with Dr. Peter Buch and Dr. Marianna Arvanitakis, Associate Clinical Professor in the Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology from the HUB Erasme Hospital in Brussels, Belgium.

Host: Mary Katherine Cheeley, PharmD, BCPS, CLS, FNLA

Guest: Carol Kirkpatrick, PhD, MPH, RDN, CLS, FNLA

The National Lipid Association (NLA) recently published updated recommendations for lifestyle therapies to manage three common dyslipidemias in adults. To discuss this, Dr. Mary Katherine Cheeley is joined by Dr. Carol Kirkpatrick, Clinical Lipid Specialist and Clinical Scientist at Midwest Biomedical Research.

Host: John Buse, MD, PhD

Guest: Anastassios Pittas, MD, MS

Vitamin D has numerous benefits, and according to a recent study, it can even help reduce the risk of type 2 diabetes in patients with prediabtes. Learn more about the key findings from this research with Dr. John Buse and Dr. Anastassios Pittas, Professor of Medicine and Chief of Endocrinology at Tufts Medical Center.

Host: Marshall Miller

This episode of Rub Some Dirt in It is getting curiouser and curiouser. See if you can solve these two cases before host Marshall Miller reveals the rare and unexpected diagnoses.