In this episode of the Dementia Researcher Podcast, guest host Dr Sam Moxon is joined by Dr Adam Schuller, Dr Savannah Rocha-Wrigley, and Megan Hager from Colorado State University's Tjalkens Lab to explore the significant yet often overlooked impact of environmental toxins on dementia and neurodegenerative diseases.

This fascinating discussion sheds light on how substances such as pesticides, heavy metals, wildfire smoke, and air pollution can trigger changes in glial cells, such as astrocytes and microglia, which may lead to dementia. The experts share insights into groundbreaking experimental models, imaging technologies, and the importance of early intervention and prevention strategies to reduce toxin-related risks.

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Key Topics:

🔷Defining environmental toxins and their relevance to dementia

🔷Role of astrocytes and microglia in neurodegeneration

🔷Translational neurotoxicology models

🔷Advanced AI imaging and analysis techniques

🔷Preventative strategies to mitigate environmental risks

Essential links / resources mentioned in the show:

Tjalkens Lab - https://bit.ly/4hMLO8w

Adam Schuller Website - https://bit.ly/3RmSLCk

WHO Air Quality & Health - https://bit.ly/3FIxqkd

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Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk

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This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

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