A new class of lower-cost alternatives to brand name drugs has emerged: biosimilars. With the development of new technology, we have new complications for antitrust litigation and to explore these issues and more Nathan, Steve, and Brent are joined by antitrust expert Catia Twal.

With the firing of the BLS commissioner in 2025 and continued issues with collecting macro data, a new NBER working paper “The Value of Reliable Statistics” by Bloom et al. tries to examine the importance of quality official statistics. And if someone is doing calculations, Steve, Nathan, and Brent are on it! In this episode they dig into the methodology and meaning of the paper and  have some suggestions for how they would run things if they were in charge of the BLS.

Nathan, Brent, and Steve are joined by Connor Moynihan to talk about the proposed changes to federal student loan caps for graduate education. Will this slow rising education costs? Will this deter necessary higher education? Which types of education will see caps and why? This is everything you need to know and more!

Employers are rolling out Large Language Models to take over their traditional hiring practices and this is creating opportunities for litigation up and down the hiring pipeline. To talk about this and other issues surrounding AI's use in hiring, Nathan, Steve, and Brent are joined by Allan G. King for his expert legal analysis.

The Department of Labor is proposing yet another rule change to classification of independent contractors and so Brent, Nathan, and Steve are here to make sense of what the criteria was, is, and will potentially be in this episode that’s all about economic independence and what work makes you an employee.

Inflation hits hard, but it can be tough to tell how hard because of how it’s measured, in this episode Brent, Steve, and Nathan talk about the problems when it comes to thinking about inflation and whether it can even be measured.

With the expansion of Large Language Models, Nathan, Steve, and Brent decided to take some time to look at how different jobs and career paths could be affected. Are we heading for a major crisis or is it overstated? The Of Significance team breaks it all down!

Nathan, Brent, and Steve talk about the prevailing wage, how it’s calculated, and why the statistics around it can dramatically change incentives and behavior. Brent finds a new way to rank himself.

This is the final episode in a series on Sports Statistics where Nathan, Steve, and Brent explore the mathematical thinking deployed by professional sports teams. In this episode, they look at point scoring strategies in basketball and baseball to understand whether people respond to new data or if some strategies are simply suboptimal.

This is the second episode in a series on Sports Statistics where Nathan, Steve, and Brent explore the mathematical thinking deployed by professional sports teams. In this episode, they are once again joined by Sush Jain to explore the concept of momentum: how well is a team doing and how well will they keep doing before things turn around?