In this On Target podcast, Dr Akila Viswanathan, Director of Radiation Oncology and Molecular Radiation Sciences at the Johns Hopkins Kimmel Cancer Center, speaks with Dr. Deborah Citrin from the National Cancer Institute's Center for Cancer Research and Dr. Zachary Morris from the University of Wisconsin School of Medicine and Public Health for an issue of Seminars in Radiation Oncology focusing on personalized dose.

The discussion explores advancements in radiation therapy, including how modern technology and biology are being used to tailor radiotherapy doses to individual patients. Dr Citrin highlights the potential of integrating genomics, imaging, and biomarkers to achieve personalized treatment, while Dr Morris examines disease-specific biomarkers and their application in clinical practice.

This episode covers key topics such as using gene expression signatures to predict radiation response, leveraging imaging for adaptive therapy, and how molecular markers are helping to refine treatment decisions. They also explore the promise of circulating tumor DNA as a tool for guiding radiation dosage and the complexities of combining radiation with immunotherapy.