OnAir, with Clinical Respiratory News

Recorded to raise awareness on World COPD Day 2024, this episode of OnAir is dedicated to chronic obstructive pulmonary disease – the third-leading cause of deaths worldwide. But as well as discussing the prevalence, underlying causes and trajectories of the condition, expert guests Professor Jean-Louis Pépin and research scientist Elroy Boers share new perspectives provided by their recent findings on the subject, including:

• How real-world evidence can better reflect the complexity and heterogeneity of COPD

Looking to the future, our guests finish on a positive note by discussing the potential beneficial impacts new COPD management strategies could have on patient outcomes and economic and healthcare burdens.

Guests:

Prof. Jean-Louis Pépin, PU-PH in Clinical Physiology, head of the HP2 research laboratory, Grenoble, France

Dr Elroy Boers, Lead Health Research Scientist, ResMed

Hosts:

Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care.

Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs. 

References and useful links:

1. Boers, M. Barrett, J.G. Su, et al. Global Burden of Chronic Obstructive Pulmonary Disease Through 2050. JAMA Netw Open. 2023;6(12):e2346598. doi:10.1001/jamanetworkopen.2023.46598

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

With 4,300 unique presentations from an estimated 30,000 authors at this year’s ERS, there was a lot of information to absorb… so we invited Dr Meredith Barrett, Vice President of Patient Health Insights at ResMed, who attended the event in Vienna, Austria, to share her highlights.

ERS’s theme was ‘Humans and Machines: Getting the Balance Right’ setting the scene for enthusiastic debate about artificial intelligence (AI) and what it means for the future of sleep and breathing health. Meredith distills the main talking points down into two key areas of insight:

Potential benefits of AI:

• Increasing the accuracy of sleep-disordered breathing diagnostics

Questions and concerns about AI:

• Whether it could undermine the patient-clinician relationship

As well as exploring these topics with host Daniela Gautschi, Meredith tells us about other aspects of the agenda that caught her attention – with a focus on digital health, novel diagnostics in sleep, understanding the future burden of respiratory disease, and how to promote treatment adherence by understanding a user’s social context.

Guest:

Dr Meredith Barrett, Vice President, Patient Health Insights, ResMed

Host:

Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care.

References and useful links:

1. Kaye, H.C. Lyson, E. Boers, A. Allen, V.T. Vuong, V. Bala, and M. Barrett. A Mixed-methods Exploration of Patient Perspectives on Pap Therapy Initiation: Implications for Improved Outreach and Education. D102. HOT TOPICS IN BEHAVIORAL SCIENCE AND HEALTH SERVICES RESEARCH. May 1, 2024, A7300-A7300

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

While research has shown that women who are diagnosed and treated for OSA may experience greater improvements in quality of life scores and higher CPAP usage than men1, actually getting a diagnosis in the first place can be an uphill struggle.

So in this episode of OnAir we invite two leading experts on the topic, Prof. Sophia Schiza and Dr Alison Wimms, to explain why this is – and what can be done so more women with OSA can enjoy the benefits of therapy sooner and for longer...

They have a lot to say on the subject, so we’ve divided up the recording by questions, so you can focus on the areas that interest you the most, or listen to it as a whole – the choice is yours!:

Introduction

• 00:51 Schiza: Why is this an important topic?

Differences between OSA presentation in men and women

• 05:02 What are the main symptoms of OSA for male and female patients?

Deep dive into female OSA research

• 27:25 Tell us more about the UK MERGE-data for mild OSA1...

Conclusion

• 43:31 What is the most important practical advice for clinicians who see women every day and want to help those with sleep apnoea?

Guests:

Prof. Sophia Schiza, Head of the ERS Assembly 4 Sleep Disordered Breathing and head of Sleep Disorders Center, Department of Respiratory Medicine at the School of Medicine, University of Crete, Greece

Dr Alison Wimms, Director of Medical Affairs in Clinical Research, ResMed

Hosts:

Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs. 

Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care.

References and useful links:

1. Wimms AJ, Kelly JL, Turnbull CD, McMillan A, Craig SE, O'Reilly JF, Nickol AH, Decker MD, Willes LA, Calverley PMA, Benjafield AV, Stradling JR, Morrell MJ; MERGE Trial Investigators. Mild obstructive sleep apnoea in females: post hoc analysis of the MERGE randomised controlled trial. ERJ Open Res. 2024 Feb 5;10(1):00574-2023. doi: https://doi.org/10.1183/23120541.00574-2023 PMID: 38333643; PMCID: PMC10851951.

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

In this episode of OnAir Professor Ulla Møller Weinreich, Head of the Danish Lung Society, explains the why, who and how of the national guidelines for home HFT her team created in 20191, including:

• Why they started using home HFT and the clinical benefits they discovered, including reduced dyspnoea, easier work of breathing and improved mucus clearance, 2 and cost-effectiveness of the treatment.3

Guest:

Professor Ulla Møller Weinreich - Head of the Respiratory Research Unit, Aalborg University Hospital, Denmark, and Head of the Danish Lung Society

Host:

Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs. 

References and useful links:

1. Storgaard LH, Hockey H, Laursen BS, Weinreich UM. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis. 2018;13:1195-1205. https://doi.org/10.2147/COPD.S159666

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

In this episode of OnAir, host Daniela Gautschi is joined by two experts in ASV therapy* and real-world evidence: Prof. Michael Arzt (READ-ASV registry1, 2) and Prof. Renaud Tamisier (FACE-cohort3, 4 and FACIL-VAA5 registries).

Experience shows that ASV can improve symptoms and quality of life for some patients with central sleep apnoea. But which patients are most likely to benefit and why? By performing large-scale database analyses, Prof. Arzt and Prof. Tamisier have been able to identify clinically meaningful clusters of CSA patients, explore phenotypes that have yet to be studied by RCTs, and shed light on the critical role played by sleep, respiratory and cardiovascular comorbidities.

Listen now to understand how this research could transform the diagnosis, treatment and prognosis of patients with persistent CSA and Treatment-Emergent CSA.

Guests:

Prof. Michael Arzt - Professor of Internal Medicine, University Hospital Regensburg, Germany

Prof. Renaud Tamisier - Professor of Clinical Physiology, Grenoble Alpes University and Director of the Sleep Exploration Centre, Grenoble Alpes University Hospital, France

Host:

Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care.

References and useful links:

1. Arzt M, Munt O, Pépin J-L, et al. Registry on the Treatment of Central and Complex Sleep-Disordered Breathing with Adaptive Servo-Ventilation (READ-ASV): protocol and cohort profile. ERJ Open Res 2023; 9: 00618-2022 [DOI: https://doi.org/10.1183/23120541.00618-2022]

• ERS workshop replay: The indication of use of ASV therapy, from evidence to clinical practice

*ASV therapy is contraindicated in patients with chronic, symptomatic heart failure (NYHA 2-4) with reduced left ventricular ejection fraction (LVEF ≤ 45%) and moderate to severe predominant central sleep apnoea.

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

The ATS (American Thoracic Society) International Conference is a key event in the global sleep and breathing health calendar. So in this episode of OnAir, we asked Kimberly Sterling and Luciana Rabello – who were there as part of ResMed’s Medical Affairs Team – to share the exciting developments and research findings that caught their attention.

Topics discussed include:

• Endotypes: what they are and how they differ to phenotypes – with a look at the role endotyping can play in the management of heterogenous conditions like OSA, and why a collaborative approach to its application may be key.

Kimberly and Luciana also tell us about connecting with peers to share scientific findings from the 26 abstracts ResMed supported at the event – including evidence that suggests PAP therapy reduces the risks of death and hospitalisation for patients with OSA.*

Guests:

Dr Kimberly Sterling - Vice President, Global Value & Access, Medical Affairs, ResMed

Dr Luciana Rabello - Director of Clinical Advocacy, Medical Affairs, ResMed

Host:

Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs. 

References and useful links:

• ATS President’s Message

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

Funded by a 15 million-euro grant from the EU’s Horizon 2020 programme for health demographic change and wellbeing, the Sleep Revolution project is an ambitious one that aims to shake up current diagnostic methods for sleep-disordered breathing (SBD).

In this episode of OnAir, we talk to the head of the project, Professor Erna Sif Arnardóttir. She tells us how she believes strong collaboration between the project’s partners convinced the EU that the Sleep Revolution project could make real change, including:

• Bringing advanced sleep diagnostics from the hospital into patient’s homes

Prof. Arnardóttir also shares her thoughts on topics such as the importance of multi-night diagnostics, whether AHI is sufficient as parameter to classify the severity of OSA, and how digital tools – such as apps and wearables – and cooperation between different entities could transform the future of sleep medicine.

Guest:

Prof. Erna Sif Arnardóttir - Director of the Reykjavik University Sleep Institute; Associate Professor at the Department of Engineering and Department of Computer Science at Reykjavik University, Iceland

Host:

Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs. 

References and useful links:

• https://sleeprevolution.eu/en

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

In this episode of OnAir, sleep clinician Prof. Dr Manuel Sánchez-de-la-Torre and host Daniela Ehrsam-Tosi discuss the potential benefits of patient phenotyping for obstructive sleep apnoea.

Prof. Dr Sánchez-de-la-Torre explores why patient phenotyping can be relevant during diagnosis, for making effective treatment decisions, and during the follow-up stage. He highlights the role of patient phenotype in predicting responses and understanding neutral effects, with a particular focus on blood pressure and hypoxic burden. He also emphasises the value of telemedicine in promoting engagement and treatment adherence.

Listen to learn why progress in patient phenotyping could affect the way you treat and understand your OSA patients.

Guest:

Prof. Manuel Sánchez-de-la-Torre - University of Lleida, principal Investigator of the ‘Precision Medicine in Chronic Disease Group’ at the Biomedical Research Institute of Lleida, Spain.

Host:

Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care.

Reference:

• Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, et al. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis. JAMA. 2023;330(13):1255–1265. https://doi.org/10.1001/jama.2023.17465

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

In this episode of OnAir, clinical expert Professor Christoph Schöbel and host Daniela Ehrsam-Tosi discuss sleep quality and sleep disorders.

There’s a growing awareness of the importance of sleep for our cardiovascular system and our general health and wellbeing. At the same time, our ability to get good sleep is increasingly challenged by everything from late-night scrolling to irregular work schedules, stress and anxiety. It’s thought that 10-30% of people worldwide suffer from insomnia1, not to mention other sleep disorders like OSA and restless leg syndrome.

In this context, which diagnostic and treatment pathways should we be prioritising? Should primary care screening programmes focus on sleep as well as diet and exercise? What benefits might digital technology have to offer? Professor Schöbel shares his thoughts on these points, as well as discussing the new European Insomnia Guideline2 and the challenges of treating COMISA (co-morbid insomnia and sleep apnoea).

Guest:

Prof. Christoph Schöbel - Professor of Sleep Medicine with a focus on Telemedicine, University Medicine of Essen, Germany

Host:

Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care.

References and useful links:

• 1. Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016 Oct-Dec;5(4):780-784. https://10.4103/2249-4863.201153. PMID: 28348990; PMCID: PMC5353813.

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed

In this episode of OnAir, we ask whether treatment-adherent OSA patients could be lowering their cardiovascular risk while they sleep. Professor Frédéric Gagnadoux and host Nina Wiklund explore the design, results and implications of his recent 5,000-patient cohort study, which indicates that CPAP can deliver a significant reduction in major adverse cardiovascular events. They ask which patients are likely to benefit, discuss the importance of hours of usage, and consider the tools that clinicians can use to support therapy adherence. Listen to learn about the potential impact of CPAP therapy on the cardiovascular health of your OSA patients.

Guest:

Prof. Frédéric Gagnadoux - Head of the department of respiratory and sleep medicine, University Hospital of Angers, France.

Host:

Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs. 

References and useful links:

• Gerves-Pinquie C, Bailly S, Goupil F, Pigeanne T, Launois S, Leclair-Visonneau L, et al.; Pays de la Loire Sleep Cohort Study Group. (2022). Positive airway pressure adherence, mortality and cardiovascular events in sleep apnea patients. Am J Respir Crit Care Med, 206, pp. 1393–1404. DOI: 1164/rccm.202202-0366OC

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

• This programme is non promotional and is sponsored by ResMed.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

© ResMed