In this expert commentary, Toby Maher, MD, PhD, discusses the evolving treatment landscape in progressive pulmonary fibrosis (PPF) and the potential implications of the longer-term FIBRONEER-ILD trial findings. He explores how nerandomilast may address key unmet needs in PPF, with a focus on disease progression, clinically meaningful outcomes, treatment sequencing, and the broader impact on patients, providers, and health care systems.

Dr Jamie Chaft discusses how longitudinal biomarker assessment can support treatment planning, resistance evaluation, and rebiopsy decision-making in NSCLC. Key topics include disease progression, tissue limitations, prior assay results, multidisciplinary collaboration, and individualized testing strategies. 

Dr Jamie Chaft reviews the biological and clinical differences among MET biomarkers in NSCLC, emphasizing the importance of matching the specific biomarker question to the appropriate assay. The discussion covers NGS, IHC, and FISH, as well as specimen availability, prior therapy exposure, and the evolving clinical context. 

Dr Jamie Chaft reviews the importance of early tissue stewardship in NSCLC, including how biopsy planning, tissue adequacy, and coordination across the care team can influence biomarker testing and treatment planning. The discussion emphasizes practical strategies to support current and future molecular testing needs. 

Umberto Vitolo, MD, discusses results from the phase 3 FrontMIND trial showing that adding tafasitamab and lenalidomide to R-CHOP significantly improved progression-free survival in patients with newly diagnosed high-risk diffuse large B-cell lymphoma, supporting this regimen as a potential new frontline standard of care regardless of molecular subtype.

Samantha Shenoy, NP, and Caitlin Costello, MD, discuss how risk stratification, early relapse patterns, and changes in disease trajectory can help oncology care teams recognize when a patient with multiple myeloma may warrant consideration for cellular therapy, including CAR T-cell therapy. The episode highlights the role of nurses and advanced practice providers in identifying clinical shifts and supporting timely multidisciplinary discussion.

Samantha Shenoy, NP, and Caitlin Costello, MD, discuss how oncology care teams can close the gap between recognizing a patient with multiple myeloma as a potential CAR T-cell therapy candidate and getting that patient to evaluation. The episode highlights referral readiness, documentation, shared-care coordination, and common barriers that can delay timely evaluation.

Elias Jabbour, MD, MD Anderson Cancer Center, Houston, Texas, discusses results from a phase 1 study showing that olverembatinib plus blinatumomab induced high response rates and deep MRD-negative remissions in heavily pretreated patients with Philadelphia chromosome–positive acute lymphoblastic leukemia.

This podcast examines the clinical utility of ctDNA-based MRD testing in diffuse large B-cell lymphoma, focusing on its role in post-treatment risk stratification, relapse detection, and treatment decision-making. Dr. David Russler-Germain reviews evidence showing that ctDNA MRD testing provides stronger prognostic value and earlier detection of recurrence than PET-CT imaging, supporting its growing integration into routine lymphoma care and NCCN-guided management.

This podcast explores the principles and clinical applications of circulating ctDNA-based MRD testing in diffuse large B-cell lymphoma, including how personalized sequencing assays can detect microscopic residual disease with greater sensitivity than imaging. Dr. David Russler-Germain discusses the growing evidence supporting ctDNA MRD testing for prognostication and treatment monitoring, while also addressing current limitations, such as variability across lymphoma subtypes and factors that can affect assay performance and interpretation.