Oncology Overdrive

In this episode, host Shikha Jain, MD, speaks with Brian Fiske about bringing biotech business ideas to fruition, antibody drug conjugate developments and more. •    Welcome to another exciting episode of Oncology Overdrive 0:14 •    About Fiske 0:21 •    The interview 1:45 •    How did you get to where you are today, and how did you become interested in this specific area of health care?  2:06 •    What is a timeline from start to finish to bringing an innovative idea to fruition?  6:01 •    How long does it take to form an actual company from an idea?  11:20 •    How do you figure out who you need on your team to move an idea forward? 15:11 •    Tell us about your previous positions at biotech companies, and how did they help lead you into your current space? 20:22 •    What excites you about your job? […] Why do you feel the drive and desire to do this type of work?  24:40 •    Where do you see the work at Mythic Therapeutics doing in the next five to ten years for patient care?  26:27 •    How can we work towards making sure this type of innovative work is available and accessible to patients?  29:20 •    If someone could only listen to the last few minutes of this episode, what would you want them to take away? 31:16 •    How to contact Fiske 32:12 •    Thanks for listening 32:56 Brian Fiske is chief scientific officer and co-founder of Mythic Therapeutics, a clinical-stage biotechnology company committed to the development of next-generation antibody-drug conjugate therapies for the treatment of a wide range of cancers.

We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Fiske can be reached via LinkedIn or the Mythic Therapeutics website.   Disclosures: Jain and Fiske report no relevant financial disclosures. 

On this special edition episode, Shikha Jain, MD, with Physicianary’s Hansa Bhargava, MD, and Mend the Gap’s Dagny Zhu, MD, discuss the evolution of empowering yourself and others and advocacy with a panel of guests.  •    Intro 1:01 •    What does it mean to empower women in medicine, and what are the ways that we can really empower others to achieve the things that they may not see for themselves?  2:39 •    What are some ways in which you have empowered or hope to empower women in medicine? Are there tips or skills that have worked well?  5:43 •    How have you been empowered by others, or have helped others find their voices?  8:38 •    Do you agree that the conversation is changing toward a cultural shift in empowerment for women in health care? 13:53 •    What are some challenges facing advocacy and empowerment? What do you do when your advocacy work is not being received or it is a struggle to speak up for someone?  18:40 •    Emphasizing the importance of communication in advocacy work. 24:00 •    Intro to Physicianary’s part 3 on physician burnout and work-life balance. 24:16 •    Thanks for listening 25:00 Vineet Arora, MD, MAPP (NAM), is a Herbert T. Abelson professor of medicine, vice dean of education in the biological sciences division and dean for medical education at the University of Chicago Pritzker School of Medicine. She is also an elected member of the National Academy of Medicine. She is a founding member of the 501c3 Women of Impact and advisor to the Women in Medicine Summit. Jennifer Bepple, MD, MMCi, is a double board-certified physician in urology and informatics. She is a member of the American Telemedicine Association, American Urologic Association and American Medical Informatics Association and holds a certification from the American Board of Telehealth and the American Board of AI in Medicine. Hansa Bhargava, MD, is Healio's chief clinical strategy and innovation officer. Listen to her Healio podcast, Physicianary. Shikha Jain, MD, FACP, is a board-certified hematology and oncology physician. She is a tenured associate professor of medicine in the division of hematology and oncology, the director of communication strategies in medicine and the associate director of oncology communication & digital innovation at the University of Illinois Cancer Center in Chicago.  Mara Schenker, MD, FACS, FAOA, is an orthopedic trauma surgeon at Grady Memorial Hospital. She is double board certified in orthopedic surgery and clinical informatics. She serves as the chief of orthopedics and associate chief medical information officer.  She is an associate professor of orthopedics at Emory University School of Medicine. She serves on multiple boards for medical and digital technology advisory and sits on major national committees for the American Academy of Orthopaedic Surgeons, AAMC, American College of Surgeons and the Orthopaedic Trauma Association. Dagny Zhu, MD, is a cornea, cataract and refractive surgeon and medical director and partner at NVISION Eye Centers in Rowland Heights, CA. She can be reached on X @DZEyeMD. We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD.  Disclosures: The hosts and guest report no relevant financial disclosures.

In this special 100th episode, host Shikha Jain, MD, speaks with her father, Krishna Jain, MD, about work-life balance pertaining to private practice, improving a fragmented health care system and more. •    Welcome to another exciting episode of Oncology Overdrive 1:18 •    About Krishna Jain 1:27 •    The interview 2:27 •    How did you end up in the United States? What was your journey to becoming a world-renowned vascular surgeon?  2:44 •    What was it like being a resident back then, especially as someone who came from abroad?  7:30 •    After training, why didn’t you go back to India? 10:12 •    Shikha Jain on how her father inspired her passion for research and mentorship.  13:19 •    Why did you choose to go into private practice, and how did you build your practice and become a leader in this space?  15:18 •    The Jains on the importance of being present for and supporting family.  19:16 •    How did your entrepreneurial life start?  23:55 •    What do your limb preservation centers do?  27:33 •    What are some things that need to be done to improve our fragmented health care system?  29:45 •    What led you found the South Asian American Vascular Society?  34:16 •    How did you end up deciding to go to Kalamazoo, MI instead of going back to India? 39:11 •    What are most proud of in your career? 41:28 •    What do you want to share with the next generation of surgeons and physicians? 44:07 •    The Jains on their relationship growing up and now. 45:44 •    If someone could only listen to the last minute of this episode, what would you want them to take away? 47:48 •    How to contact Jain 48:48 •    Thanks for listening 50:43 Krishna Jain, MD, is a vascular surgeon who has been intimately involved in the growth of office based endovascular centers throughout the country since 2007.

We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Krishna Jain can be reached via email [email protected].  Disclosures: Jain reports no relevant financial disclosures. 

In this special throwback episode, Shikha Jain, MD, talks with Olympic champion Kikkan “Kikkanimal” Randall, about how her positive attitude and athlete mentality have helped her navigate a breast cancer diagnosis and treatment, valuable advice for both oncologists and patients and more. •    Intro 1:44 •    About Randall 1:58 •    The interview 3:22 •    Tell us a bit about you. Who are you? How did you get to where you are and how did you decide you wanted to be a part of the U.S. Olympic cross-country ski team? 3:51 •    How were you diagnosed? 6:12 •    How old were you when you first realized that you had this pebble in your breast? 7:33 •    What type of mentality is it that makes you such a phenomenal Olympic athlete that you were able to translate into this taking charge of your health and taking charge of your cancer as you move forward? 9:20 •    What was the best way for you to cope as you felt this loss of control going through your treatment in certain times? 12:09 •    What did you do to prepare for your clinic visits when you were trying to advocate for yourself? 16:17 •    Can you talk more about the video blog you kept during treatment? 17:55 •    How did you navigate the disease with your son? 21:50 •    How long do they recommend for you to wait to try again (to conceive)? Did you have those conversations? 26:17 •    Do you feel like you are mentally approaching this period of your post-cancer care or your post-treatment time? 29:58 •    Randall running a marathon following the completion of her treatment 32:07 •    How did you get involved with Healthy Futures and Fast and Female, and what exactly do they do? 38:08 •    Did the way that you participate in advocacy change after you were diagnosed with cancer? 42:46 •    One thing you wish oncologists knew when they are treating patients with any kind of cancer, and one thing patients should know if they’re newly diagnosed? 48:09 •    How to find Randall 50:26 •    Thanks for listening 51:58 Kikkan Randall is an Olympic champion, active mom, cancer fighter and “Get-Activist.”  We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Randall can be reached at kikkan.com.  Disclosures: Jain reports no relevant financial disclosures. 

In this episode, host Shikha Jain, MD, speaks with Shyam Natarajan, PhD, about machine learning in cancer research and testing, using technological innovation to address disparities in health care trials and more. •    Welcome to another exciting episode of Oncology Overdrive 1:17 •    About Natarajan 1:22 •    The interview 2:10 •    How did you get into the medical technology space?  2:29 •    Can you explain what machine learning means?  4:37 •    How did you end up co-founding Avenda Health?  7:18 •    Do you think that this type of technology is replicable in other disease types as well? […] Where else do you see this being a benefit? 9:53 •    When you think about AI, what are the other applications for this type of technology outside of oncology?  11:24 •    How do you respond to concerns that AI is becoming too sentient or independent?  12:50 •    What are the checkpoints we need to put in place to make sure that biases in AI algorithms do not become the norm?  16:21 •    Do you have ways to predict who would benefit from these types of technology, and can you categorize patients into who is appropriate for trialing these technologies?  19:44 •    Is there a way to utilize this technology to address disparities in health care?  22:04 •    Have you found that there are specific things that make it harder to enroll patients in these particular clinical trials? How do you navigate those? 24:47 •    If you had a crystal ball that could see fifty years into the future, where do you see all of this technology going? 27:28 •    If someone could only listen to the last few minutes of this episode, what would you want them to take away? 30:56 •    How to contact Natarajan 31:31 •    Thanks for listening 32:22 Shyam Natarajan, PhD, is the co-founder and CEO of Avenda Health, a medtech company focused on improving outcomes for the one in seven men at risk for prostate cancer.

We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Natarajan can be reached at www.avendahealth.com or via LinkedIn.  Disclosures: Jain and Natarajan report no relevant financial disclosures. 

In this episode, host Shikha Jain, MD, speaks with Komal Jhaveri, MD, about breakthroughs in breast cancer treatment, where the field is evolving with anti-body drug conjugates and more. •    Welcome to another exciting episode of Oncology Overdrive 1:17 •    About Jhaveri 1:21 •    The interview 1:41 •    How did you get into this highly specialized field? […] How did you become a breast oncologist and find yourself at Memorial Sloan Kettering?  2:07 •    As a breast oncologist, what has really excited you in the breast cancer space over the last decade?  5:02 •    What do you think is going to happen in the next five to twenty years? Where do you think breast cancer treatment is going to evolve?  13:44 •    Do you think AI is going to have a big impact on how we treat patients? 17:47 •    If someone could only listen to the last minute of this episode, what would you want them to take away? 19:52 •    How to contact Jhaveri 20:34 •    Thanks for listening 21:32 Komal Jhaveri, MD, is a breast oncologist & early drug development specialist, clinical director of the early drug development service, and section head of the endocrine therapy research program at Memorial Sloan Kettering Cancer Center (MSK).

We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Jhaveri can be reached at her office 646-888-5157, or via email [email protected].  Disclosures: Jain reports no relevant financial disclosures. Jhaveri reports she is the principal investigator for Genentech’s INAVO120 trial at MSK and co-chair globally.

In this episode, host Shikha Jain, MD, speaks with David Cosgrove, MD, about implementing real-world utilization of clinical trials, the importance of diversity in clinical trials and more. •    Welcome to another exciting episode of Oncology Overdrive 1:17 •    About Cosgrove 1:26 •    The interview 2:54 •    How did you make your way from Ireland to Portland, Oregon?  3:18 •    As a fellow GI oncologist, what are you excited about in the cancer research space?  6:13 •    How can we realistically address disparities in cancer care to deliver the latest breakthroughs to patients?  8:54 •    Jain and Cosgrove on the challenges GI cancers experience in terms of delivery of cancer care compared to colleagues in other spaces. 11:22 •    What excites you about what’s happening in oncology right now, and where we’re going in this space? 13:30 •    How did you end up as medical director at Compass Oncology?  15:15 •    What are you specifically working on now, and where do you hope to see it go in the next five years?  17:25 •    How do we get more patients from different backgrounds into clinical trials, and why is it important that we do that? 19:05 •    Jain and Cosgrove on challenges facing patient guidelines and qualifications for clinical trials. 21:09 •    If someone could only listen to the last few minutes of this episode, what would you want them to take away? 23:41 •    How to contact Cosgrove 24:45 •    Thanks for listening 25:49 David Cosgrove, MD, serves as the medical director of Compass Oncology in Portland, Oregon, and specializes in general adult oncology with advanced subspecialty expertise in gastrointestinal cancers.

We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Cosgrove can be reached via email [email protected].   Disclosures: Jain and Cosgrove report no relevant financial disclosures. 

In this episode, host Shikha Jain, MD, speaks with MOLLI Surgical co-founder and CEO, Ananth Ravi, about inventing surgical technology to provide better patient care, addressing inequities in surgical tool access and more. •    Welcome to another exciting episode of Oncology Overdrive 1:15 •    About Ravi 1:27 •    The interview 2:10 •    Tell me about how entered this field and how you ended up founding a company that invents surgical instruments.  2:42 •    How did you end up moving from Zambia to Canada?  5:02 •    Tell me more about MOLLI Surgical. How is this precision surgery unique from what is already out there?  6:47 •    What is your background to help you go from ideation to implementation, and how did you take the steps to make your ideas a reality? 10:31 •    How do you address rural and global disparities when it comes to accessing these technologies?  16:12 •    In an ideal world, where would you see this technology being utilized, and are there any other technologies that you think will revolutionize this type of care?  19:32 •    What else excites you about this space? […] How did you find going from the academic space into this role in the business/corporate space?   22:19 •    Jain and Ravi on work-life balance.  25:51 •    What’s next for you in the next three to five years?  29:26 •    If someone could only listen to the last few minutes of this episode, what would you want them to take away? 30:15 •    How to contact Ravi 30:42 •    Thanks for listening 31:39 Ananth Ravi is president, CEO and co-founder of MOLLI Surgical.

We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Ravi can be reached at www.mollisurgical.com or via email [email protected].  Disclosures: Jain reports no relevant financial disclosures. Ravi reports he is president, CEO and co-founder of MOLLI Surgical.

In this episode, host Shikha Jain, MD, speaks with Cyclacel CEO, Spiro Rombotis, MPH, about developing techniques and therapies for drug development, how technology has affected these advancements and more. •    Welcome to another exciting episode of Oncology Overdrive 1:15 •    About Rombotis 1:23 •    The interview 2:21     •    Can you tell us about how you ended up in the biotech and pharma spaces?  2:41 •    How did you transition to the first CEO of Cyclacel, and what has kept you in the same space for over three decades?  4:45 •    Is this how you envisioned your career? How did this vision evolve over the course of your career?  8:53 •    What does Cyclacel do, and can you describe the types of innovation you are doing there? 10:19 •    With all this new and exciting technology in the field, where do you see epigenetics and precision oncology going in the next ten to twenty years?  15:46 •    What are your thoughts on AI in the oncology space?   22:21 •    Jain and Rombotis on checks and balances when it comes to AI use in cancer care and clinical trials.   27:53 •    What’s next for you?  30:53 •    If someone could only listen to the last few minutes of this episode, what would you want them to take away? 36:18 •    How to contact Rombotis 40:25 •    Thanks for listening 40:43 Spiro Rombotis, MPH, is the CEO of Cyclacel. He has over 36 years at three public biotechs and two pharmas.

We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Rombotis can be reached via email [email protected].  Disclosures: Jain reports no relevant financial disclosures. Rombotis reports Cyclacel Ltd employment and stock ownership.

In this episode, host Shikha Jain, MD, speaks with Jennifer Michaelson, PhD, about how to seek out opportunities in the health care industry, making space for diversity in biotech innovation and more. •    Welcome to another exciting episode of Oncology Overdrive 1:15 •    About Michaelson 1:21 •    The interview 2:30     •    Can you tell us about how you ended up in the biotech executive space?  2:47 •    How do people get involved in this type of work?  12:32 •    Tell us about sourcing innovation in biotech, along with the challenges that come with it. 16:46 •    How do you consider patient access when thinking about innovations in the biotech space? 21:15 •    When you think about the challenges facing leadership and diversity in these spaces, how can we create an inclusive culture in the health care space? What have you done to spearhead a culture of DEI?  23:51 •    Jain and Michaelson on organizations infusing DEI concepts into standards of practice and care. 30:58 •    If someone could only listen to the last minute of this episode, what would you want them to take away? 32:16 •    How to contact Michaelson 33:52 •    Thanks for listening 34:23 Jennifer Michaelson, PhD, is chief scientific officer at Cullinan Therapeutics. Michaelson is a biotech executive with 20+ years of industry experience in oncology, immunology, and immune-oncology drug development.

We’d love to hear from you! Send your comments/questions to Dr. Jain at [email protected]. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Michaelson can be found on LinkedIn or via email [email protected].  Disclosures: Jain and Michaelson report no relevant financial disclosures.