In this podcast episode, Paul Limburg, MD, MPH, discusses the movement from academics to industry, developments in colorectal cancer screening tools and more. • Intro 1:11 • Paul Limburg, MD, MPH 1:17 • How did your early influences and childhood years lead you to become interested in gastroenterology and the career you have today? 1:34 • Who were your early inspirations? 2:14 • How did you transition from a career in academics and sciences to a life on the commercial side? 3:34 • How did your role at Exact Sciences come about? 5:58 • Was it a hard decision to take a new position? 7:47 • Chey and Limburg on the joy of advancing science and innovation. 9:03 • Were there any cultural differences that shocked you about the ways work is done in your previous and current positions? 10:10 • Do you see Exact outsourcing scientific research as the company grows? 12:12 • What does a typical day look like for you at Exact? […] What are you responsible of as the leading physician? 13:28 • From a product standpoint, what is ahead on the roadmap for Exact Sciences? […] What are you most excited about regarding next-generation multi-target stool testing and its impact? 15:14 • How do you respond to gastroenterologists' skepticism and concerns surrounding stool-based screening? 21:15 • What about addressing the concerns surrounding how we can ensure patients with a positive FIT test go in for a colonoscopy? 23:22 • How much of an issue are language barriers when it comes to screening tools? 28:11 • Can you talk about how Exact Sciences are using AI and the evolution of the microbiome internally or in product development? 29:42 • Do you see a future for stool-based testing in between/in combination with colonoscopies? 32:59 • Have you noticed differences in sensitivity and specificity based on age? 34:07 • What are your thoughts on making these tools available in a direct-to-consumer offering? […] How do you make these screening tools more readily available while weighing the usage risks? 35:08 • What is the rate of patients who have a positive stool-based test getting a colonoscopy? 38:44 • If you were talking to a GI fellow deciding to make the jump to industry, what do you tell them? 41:58 • Thank you, Paul 44:55 • Thanks for listening 45:21

Paul J. Limburg, MD, MPH, is chief medical officer for screening at Exact Sciences and emeritus professor of Medicine at Mayo Clinic.

We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Dr. Limburg, follow @limburg_paul and @ExactSciences on X. Disclosures: Chey and Berry report no relevant financial disclosures. Limburg reports he is an employee of Exact Sciences.

In this podcast episode, Amy Oxentenko, MD, discusses her initiatives as ACG president, addressing workforce challenges in the GI space and more. • Intro :50 • Amy Oxentenko, MD 1:09 • How does it feel to be finishing your year as ACG president? 1:54 • What were your main initiatives and goals for this year, and how did they go? 3:28 • Is there a teaser you can give us for what you will reveal at the ACG annual meeting? 8:39 • Chey and Oxentenko on the critical role of additional research within the future of gastroenterology. 12:01 • What research has the college conducted to better understand the true clinical FTE available to patients? […] Are there certain solutions that have stood out to you in your work? 13:19 • Will there be a task force to comment on the rise of clinicians choosing to participate in more of a locum tenens practice? 18:35 • Can you speak about the recent progress made toward addressing the gender gap in GI? 21:32 • What can listeners do in this political climate to continue to make strides towards equity in the field? 25:47 • What have you learned about yourself in the past year as ACG president? 30:09 • What are you optimistic about in GI after this year? 33:19 • On the other hand, what are you most concerned about for gastroenterology? 36:17 • Any advice for the next ACG president? 39:31 • What is next for you? 41:18 • Thank you, Amy 43:10 • Thanks for listening 43:52 Amy Oxentenko, MD, FACP, FACG, AGAF, is a professor of medicine and vice dean of Mayo Clinic Practice. She is a member of the ACG board of trustees and executive team, serving as ACG president from October 2024-October 2025.

We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Dr. Oxentenko, follow @AmyOxentenkoMD on X. Disclosures: Chey, Berry and Oxentenko report no relevant financial disclosures.

In this special crossover podcast episode, Tuesday Night IBS hosts Jeffrey Roberts, MSEd, BSc, Erica Dermer and Kate Scarlata, MPH, RDN, are joined live by William Chey, MD, and Amanda Lynett, MS, RDN, at FOOD the Main Course Conference in Ann Arbor, MI. • Intro :02 • About Scarlata :30 • About Chey 1:07 • About Lynett 1:49 • Chey, what are your goals for this year's FOOD the Main Course Conference? 2:58 • How do you feel that mechanisms of diet are affecting microbiomes? 5:37 • Amanda, what have you learned over the years as you have put together this conference, and how do you think this experience has shaped a more well-rounded program for clinicians? 8:23 • What are you personally going to take away from the conference this year? 11:17 • A discussion on peer-to-peer interactions, the spirit of collaborative care, and what each provider is bringing to the table. 12:22 • Kate, tell us about why you come back to this conference every year. 17:32 • What challenges did you overcome to move the needle forward in diet and GI conditions? 19:14 • Chey, can you talk about the correlation between stress and diet when it comes to IBS? 24:21 • How are we dealing with the ramifications of GLP-1s? 29:33 • As providers, what is your first instinct when patients tell you they started GLP-1s? 32:28 • How is the community going to help listeners weed through Internet noise to find accurate information? 35:01 • Group discussion on the rise of severe constipation. 41:31 • Who decides to send patients for colectomy consultations? 43:33 • Is there anything else you want to share or highlight from the conference? 47:25 • Thank you all 48:58 • Thanks for listening 49:42 Erica Dermer is an IBS and Celiac Disease patient who hosts the Celiac and the Beast blog and You Had Me at Eat podcast series. Amanda Lynett MS, RDN, is a registered dietitian with her masters. Amanda is with the Division of Gastroenterology at Michigan Medical in Ann Arbor. Jeffrey Roberts, MSEd, BSc, is a patient advocate and creator of the first website for IBS sufferers. He is the co-founder of Tuesday Night IBS. Kate Scarlata, MPH, RDN, is a US-based dietitian with over 30 years of experience. Kate's expertise is in gastrointestinal disorders and food intolerance. We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more Tuesday Night IBS, be sure check out TuesdayNightIBS.com and to follow and subscribe to their podcast. Disclosures: Chey and Roberts report no relevant financial disclosures. Scarlata reports stock options with Epicured LLC and FODY Food Company, financial support from Dr. Schar, Mahana Therapeutics, Nestle Health Science, Olipop, Pendulum, QOL Medical.

In this podcast episode, Miguel Regueiro, MD, discusses developing the medical home model for patients with IBD, technological advances for patients in GI and more. • Intro :58 • The interview/about Regueiro 1:03 • Tell us about your family and where you grew up. 1:24 • How did you get interested in medicine? 2:16 • Who were your early influences? 4:18 • What is the medical home? 5:57 • How did you develop the idea to apply the medical home model to IBD? 7:45 • Did you get any funding from the payers for this model to keep costs under control for this patient population? 10:57 • Why hasn't this model become standard of care for patients with complex IBD? 14:13 • What has worked, and what hasn't worked when it comes to adopting an integrative care medical home model? 18:15 • Are there themes patients share as to why they wouldn't want to be enrolled in a medical home? 21:28 • What motivated your change to go from UPMC to become the GI Chief of Cleveland Clinic? 23:09 • What have you learned in this position at Cleveland Clinic? 25:23 • Are you spending a lot of time on the business side of care as opposed to the patient side? 26:34 • How would you recommend that people prepare for having a position like this? 27:34 • Are you seeing a shift in excitement over taking on leadership roles outside of traditional academics? 30:02 • With our clinical tool chest changing so rapidly, is there a common theme that you use to guide the strategy of the institute on what to invest in? 35:06 • What are the challenges that you still see in the ways we are using telehealth? 39:05 • What are some of the most exciting things you see on the horizon in the realm of IBD management? 40:26 • Thank you, Miguel 42:55 • Thanks for listening 45:11 Miguel Regueiro, MD, is the chief of the Digestive Disease Institute at Cleveland Clinic, and professor in the department of medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Regueiro, follow @MRegueiroMD on X. Disclosures: Berry and Chey report no relevant financial disclosures. Regueiro reports being on the advisory boards of and consulting for Abavax, Abbvie, Amgen, Biocon, BMS, Boehringer Ingelheim Pharmaceuticals Inc. (BIPI), Celgene, Celltrion, Gilead, Genentech, Johnson and Johnson, Lilly, Merck, Organon, Pfizer, Prometheus, Roche, Salix, Sanofi, Takeda and UBC.

In this podcast episode, Ryan Stidham, MD, discusses the evolution and development of digital imaging and AI in the GI space, how AI can revolutionize stages within the clinical trials and practices and more. • Intro :24 • The interview/about Stidham :36 • Tell us about your family and where you grew up. 1:14 • How did you embrace changes in technology growing up? 3:07 • What was the seminal moment that got you to move from being a consumer of information to being a producer and innovator? 6:05 • What ignited you to start commercializing and patenting your ideas, and operationalizing them into a company? How did that evolution occur? 8:32 • Can you give a quick overview of what these tools and technologies entail? 12:52 • What got you interested in inflammatory bowel disease, and how did your childhood interest in coding shift to artificial intelligence? 18:12 • Where did your interest in AI come about? 20:26 • You recently published a review on how AI will revolutionize the conduct of clinical trials in inflammatory bowel disease […] Will AI remove the need for central reading in IBD trials in the future? 23:58 • How do we change the way we train GI doctors, and should we start making these changes today? 26:38 • With AI rapidly changing the landscape, are we spending enough time educating our fellows in how to adapt to changes and communicate with patients? 32:33 • What do you think will change in IBD and gastroenterology in the near term as a result of AI? 35:06 • What is it that we really need in terms of health care access, and how can AI technology assist these needs? 38:39 • Thank you, Ryan 44:04 • Thanks for listening 44:20 Ryan Stidham, MD, MS, AGAF, is a translational scientist caring exclusively for patients with inflammatory bowel disease. He is an associate professor in the department of medicine and the department of computational medicine and bioinformatics where he serves as the associate chair of translational research. His research focus is the use of artificial intelligence to improving measurement of IBD and other gastrointestinal diseases, developing new interpretations of cross-sectional imaging, endoscopy, medical text, and other electronic data. We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Stidham, follow @CrohnsDoc on X. Disclosures: Berry and Chey report no relevant financial disclosures. Stidham reports consulting or on advisory boards for AbbVie, Bristol Myers Squibb, CorEvitas, Eli Lilly, Exact Sciences, Gilead, Janssen, Merck, Pfizer, and Takeda. Stidham holds intellectual property and equity on medical imaging and endoscopic analysis technologies licensed by the University of Michigan to PreNovo, LLC, AMI, LLC and PathwaysGI, Inc.

In this special crossover episode with Physicianary, previous Gut Talk guest, Austin Chiang, MD, and Physicianary host, Hansa Bhargava, MD, discuss the influence of social media in medicine and how AI continues to change the health care landscape. • Intro 0:30 • Austin Chiang, MD, MPH 0:36 • Tell us about your journey. 1:02 • How did you get involved with being a social media officer at your institution? 3:58 • Where do you think doctors should see themselves in the future of social media in medicine? 6:49 • What are the ways in which you see AI tech making a difference? 9:12 • Do you agree that it is helpful for doctors to be involved with product development and integration on an industry level? 12:14 • Can you give us some insight on the process of putting through new CPT codes as a company? 14:41 • Tell me more about your book, Gut: An Owner's Guide (The Body Literacy Library). What motivated you to write this book, and what do you think people will get out of it? 18:35 • If you were the "king of health care", what would you work on first? What is the most important aspect of health car that you think needs fixing? 21:23 • What's your favorite food? 25:24 • How to reach Chiang. 26:01 • Thanks 26:20 Austin Chiang, MD, MPH, is the first chief medical officer for the endoscopy business of Medtronic, the global leader in health technology. He is also currently an assistant professor of medicine at an academic teaching hospital in Philadelphia, PA, and serves as the director of the Endoscopic Weight Loss Program.

Listen to Gut Talk's very first episode with Dr. Chiang from 2019, Social Media in Medicine. We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. Follow Dr. Bhargava on X @hansabhargavaMD and on Instagram @doctorhansaMD. Follow Dr. Chiang everywhere on social media @AustinChiangMD.

Disclosures: Bhargava reports no relevant financial disclosures. Chiang reports he is the chief medical officer for Medtronic Endoscopy.

In this podcast episode, Prateek Sharma, MD, about how program directors can help shepherd GI fellows into clinical research spaces, providing quality exams for upper endoscopy and more. • Intro :24 • The interview/about Sharma :43 • Tell us about your family and where you grew up. 1:00 • Did you encourage your son to go into medicine? 2:17 • What kinds of doctors were your parents? 3:40 • Who were your big, early influences? 4:08 • If you didn't always want to be a doctor, what convinced you to change your mind? 6:11 • When did you make the decision to go into academic medicine as a career? 7:16 • Are you seeing fewer and fewer fellows interested in pursuing a career in academic medicine? […] Are there ways to counsel fellows to be more interested in this type of work? 9:49 • How long have you been a program director, and are you still enjoying the work? 13:58 • How did you choose to into internal medicine and GI? 17:22 • As leaders of academic research centers, what have you done or plan to do in the face of potential cuts to the NIH overhead rates? 18:40 • How are we doing right now as a country and globally in terms of early detection of Barrett's neoplasia? 22:08 • Why has performing high-quality surveillance and screening of procedures like colonoscopy been so much more successful than performing high-quality exams for upper endoscopy? 25:33 • If the biggest hurdle to performing these exams is time, do you feel that more education around how to perform a high-quality exam will move the needle, or are other incentives needed? 28:32 • Do you think AI-based detection is overhyped or underhyped in GI? 30:33 • What are your thoughts on DNA-based testing for conditions like Barrett's neoplasia, and how should they be incorporated into standard practice? 34:24 • What are your priorities as president of the American Society of Gastrointestinal Endoscopy this year? 38:42 • What do you see as the biggest threats or concerns to gastroenterologists? 42:25 • Final thoughts? 46:32 • Thank you, Prateek 47:13 • Thanks for listening 47:15 Prateek Sharma, MD, FASGE, FACP, FACG, is professor of medicine and director of the GI fellowship program at the University of Kansas School of Medicine.

We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Sharma, follow @KUcancercenter and @ASGEendoscopy on X and Instagram.

Disclosures: Berry and Chey report no relevant financial disclosures. Sharma reports consulting for Boston Scientific Corporation, CDx Labs, Cipla, Exact Sciences, Medtronic, Olympus Corporation, Salix Pharmaceuticals, Samsung Bioepis and Takeda and provides grant/research support to ERBE USA Inc., Fujifilm Holdings America Corporation, Ironwood Pharmaceuticals Inc. and NEC.

In this podcast episode, Maria Abreu, MD, current president of the AGA, discusses the unique upbringing of health care professionals who are children of immigrants, formal versus on-the-job leadership training and more. • Intro :24 • The interview/about Abreu :31 • Can you tell us about where you grew up and the impact your family had on the work you're doing now? :54 • Chey and Abreu on the profile in Gastroenterology in May 2024, which announced Abreu as the current AGA president and summarized her personal and professional life. 3:08 • Abreu on her father's involvement with the Bay of Pigs invasion in Cuba. 7:00 • Chey and Abreu on the impact of an upbringing as children of immigrants. 12:02 • How did you get interested in GI, specifically in IBD? 13:00 • When did it become apparent to you that you were interested in more than traditional academia and clinical medicine, and wanted to inspire and have a broader impact? 17:37 • What would you say to a younger physician or someone earlier in their career about formal leadership training versus on-the-job training? […] Do you think this generation needs formal training in how to manage people as health care becomes more complex? 21:11 • Do you think that the future of academia and the phenotype of who is going to lead in academic divisions will change? 28:40 • What are your priorities during your presidential year at AGA? 34:24 • What have you learned so far as president of the AGA? Has anything struck you as surprising? 42:03 • Thank you, Maria 44:12 • Thanks for listening 44:45 Maria T. Abreu, MD, is the current president of the American Gastroenterological Association. She is the fifth woman to lead AGA as president and the association's first Latino president. Dr. Abreu currently serves as the Martin Kalser Endowed Chair of Gastroenterology; professor of medicine, microbiology and immunology; and director of the Crohn's and Colitis Center at the University of Miami. We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Abreu, follow @ibddocmaria on X. Disclosures: Berry and Chey report no relevant financial disclosures. Abreu reports receiving consultant fees from serving on pharmaceutical advisory boards.

In this podcast episode, Larry Kosinski, MD, founder of SonarMD, discusses reclaiming GI services for patients and physicians, developing new tools for IBD patients and more. • Intro :24 • The interview/about Kosinski :29 • Can you tell us about your upbringing and the experiences that got you to where you are today? What got you interested in gastroenterology? :55 • Of the many "chapters" in your story, can you talk about your merger and acquisition experience in the medical field? How has the process of different GI groups coming together changed over time? 5:40 • Why did the investors of SonarMD want to confine activities to just IBD and not scale it? 20:49 • Chey and Kosinski on the issues of moving away from patients being at the center of the decision-making and equal partnership in mergers and acquisitions. 22:03 • Chey and Kosinski on what drives physician burnout in gastroenterology. 25:06 • Do you feel that solutions focused on addressing cost in IBD is going to be as effective as solutions in addressing costs associated with functional diseases? 28:02 • What do you see next for SonarMD, and how has your own transition into your next "chapter" been? 32:24 • Berry, Chey and Kosinski on the development of tools to assist patients with IBD and diagnose GI conditions. 40:10 • What have you learned from the different projects you have worked on, and what advice would you give gastroenterologists interested in this type of innovation? 42:20 • Thank you, Larry 44:09 • Thanks for listening 44:33 Lawrence R. Kosinski, MD, MBA, AGAF, FACG, is a retired gastroenterologist who practiced for 35 years in suburban Chicago and is one of the founders of Illinois Gastroenterology Group, the largest independent GI practice in Illinois. We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Kosinski, follow @lrkosinski on X. Disclosures: Berry, Chey and Kosinski report no relevant financial disclosures.

In this podcast episode, Tom Serena, chief executive officer of the American Gastroenterological Association, discusses the role of private equity in specialty societies, the hunger to be involved in innovation and more. • Intro :24 • The interview/about Serena :29 • Can you tell us about your upbringing and how it helped you become who you are today? :50 • Were there certain early individuals or experiences that you think have been impactful or important to your career today? 1:43 • Have you always been a natural leader, or did you grow into it? 2:38 • What are some things you learned from your coach? 3:30 • Is there a pathway that you unintentionally took that led you to medical societies and medical society leadership? 5:09 • Over the thirty years you have been involved with the American Gastroenterological Association (AGA), when did you know that you were going to be a core part of the leadership team? 6:38 • How have you seen the GI field change over the last thirty years? 8:24 • Do you think there has been a shift in the culture of our specialty for major organizations like AGA to be more open to a wider range of physicians and stake holders? 11:00 • Where do you think we're going over the next few years with private equity? 14:08 • Can you tell us more about the AGA's GI Opportunity Fund? What prompted the AGA to partner with venture capital and how has the experience been so far? 19:19 • Are there things that organization leaders are more likely to invest or not invest in? 21:47 • Berry, Chey and Serena on non-traditional ways physicians are looking to make use of their medical training. 23:24 • How have larger legacy societies like AGA and ACG view the emergence of more nuanced clinical societies, and how do they impact the way the AGA tries to execute its mission? 27:05 • Can you talk about ABIM's impact on health care and the GI specialty? 30:01 • What are some of the biggest challenges facing AGA and GI as a field moving forward? 33:17 • Outside of the Opportunity Fund, what are other ways that the AGA is working to solve challenges around physician burnout, autonomy and reimbursement? 34:43 • Any life lessons you want to share with listeners? 36:22 • Thank you, Tom 37:39 • Thanks for listening 37:58 Tom Serena is chief executive officer of the American Gastroenterological Association. Tom joined AGA in 1994 and has served as the organization's CEO since 2010. His previous role was VP of finance. He has been heavily focused on governance, helping the governing board to become the stewards of AGA's future, with an emphasis on strengthening board - committee - staff relationships. We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on X @HealioGastro @sameerkberry @umfoodoc. For more from Serena, follow @TSerenaAGA on X. For more from the AGA, visit www.gastro.org and follow @AmerGastroAssn on X. Disclosures: Berry and Chey report no relevant financial disclosures. Serena reports he is an investor in the GI Opportunity Fund.