Editor-in-Chief Paul Y. Kwo, MD, FACG and Associate Editor Elie S. Al Kazzi, MD, MPH discuss "Tofacitinib in acute severe ulcerative colitis (TACOS): A randomized controlled trial," by Singh A, Goyal MK, Midha V, et al. Am J Gastroenterol 2024; 119 (7), 1365-1372.

Margaret J. Zhou, MD, MS and Timothy Yen, MD discuss "Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence," by O'Sullivan T, Mandarino FV, Gauci JL, et al. Gut. 2024 Dec 10;74(1):67-74.

Margaret J. Zhou, MD, MS and Timothy Yen, MD discuss "Germline CDH1 variants and lifetime cancer risk,” by Ryan CE, Fasaye G, Gallanis AF, et al. JAMA. 2024;332(9):722–729.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Bharati Kochar, MD, MS discuss “Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis,” by Sands BE, Feagan BG, Biroulet LP, et al. N Engl J Med. 2024; 391: 1119-29.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Cold Versus Hot Snare Endoscopic Resection of Large Nonpedunculated Colorectal Polyps: Randomized Controlled German CHRONICLE Trial,” by Steinbrück I, Ebigbo A, Kuellmer A, et al. Gastroenterology. 2024 Sep;167(4):764-777

Philip Schoenfeld, MD, MSEd, MSc (Epi) discusses “Combination of Carvedilol with Variceal Band Ligation in Prevention of First Variceal Bleed in Child-Turcotte-Pugh B and C Cirrhosis with High-Risk Oesophageal Varices: the ‘CAVARLY’ Trial,” by Tevethia HV, Pande A, Vijayaraghavan R, et al. Gut. 2024; 73: 1844-53.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MS discuss “Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial,” by Summarizing Rothenber M, Dellon E, Collins M, et al. Lancet Gastroenterol Hep. 2023; 9: 990-1004

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Elie S. Al Kazzi, MD, MPH discuss “Subcutaneous Infliximab (CT-P13 SC) as Maintenance Therapy for Inflammatory Bowel Disease: Two Randomized Phase 3 Trials (LIBERTY),” Gastroenterology. 2024;167:919–933.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Christopher Velez, MD discuss “Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease,” by Fass R, Vaezi M, Sharma P, et al. Aliment Pharmacol Ther. 2023 Nov;58(10):1016-1027.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Margaret Zhou, MD, MS discuss “Colonoscopy quality measures and adherence to follow-up guidelines among endoscopists participating in a U.S. endoscopy registry,” by Shapiro JA, Holub JL, Dominitz JA R, et al. Gastrointest Endosc. 2024 Aug 5:S0016-5107(24)03404-7.