His study significantly shapes our understanding of glioblastoma treatment by introducing an innovative approach that combines photodynamic therapy (PDT) with necroptosis induction. By targeting glioblastoma stem cells—those most resistant to conventional therapies—this method offers new possibilities for more precise surgical outcomes, reduced recurrence, and the development of personalised treatment strategies. Findings demonstrate that inducing necroptosis, a regulated form of cell death, following PDT could bring about notable clinical benefits, particularly by addressing glioblastoma’s well-known resistance to apoptosis. This marks an important advancement in tackling the complexities of glioblastoma treatment, with the potential to improve therapeutic outcomes and extend survival rates for patients facing this aggressive brain tumour.

dx.doi.org/10.13140/RG.2.2.28609.98400