Full text - http://bit.ly/2hTOg0O

Oncotarget | Interview with Dr. Dmitrovsky from the University of Texas MD Anderson Cancer Center, Houston, TX talking about their featured cover paper in Oncotarget Volume 8 Issue 1 "The ISG15-specific protease USP18 regulates stability of PTEN"

Facebook - http://bit.ly/2xznxjV

Twitter - http://bit.ly/2xzWvsu

LinkedIn - http://bit.ly/2xzJ6kc

Pintrest - http://bit.ly/2xzX8SS

Reddit - http://bit.ly/2hoxI0N

www.Oncotarget.com

Full text - http://bit.ly/2yWQ6Jx

Oncotarget | Interview with Dr. Bruno Larrivee from Departments of Biomedical Sciences, Molecular Biology and Ophthalmology - Maisonneuve-Rosemont Hospital Research Center, University of Montreal, Montreal, Quebec, Canada & Department of Biological Sciences Université du Québec à Montréal, Montréal, Quebec, Canada talking about their featured cover paper in Oncotarget Volume 7 Issue 35 "BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration"

Facebook - http://bit.ly/2xznxjV

Twitter - http://bit.ly/2xzWvsu

LinkedIn - http://bit.ly/2xzJ6kc

Pintrest - http://bit.ly/2xzX8SS

Reddit - http://bit.ly/2hoxI0N

www.Oncotarget.com

Full text - http://bit.ly/2hqMzYN

Oncotarget | Interview with Dr. Anutosh Ganguly from the Department of Integrative Biology and Pharmacology, University of Texas Medical School, 6431 Fannin St., Houston, Texas 77030, USA talking about their research published in Volume 2 Issue 5 titled "Class III β-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration"

Facebook - http://bit.ly/2xznxjV

Twitter - http://bit.ly/2xzWvsu

LinkedIn - http://bit.ly/2xzJ6kc

Pintrest - http://bit.ly/2xzX8SS

Reddit - http://bit.ly/2hoxI0N

www.Oncotarget.com

Full text - http://bit.ly/2hR9kW0

Oncotarget | Interview with Dr. Hirbe from the Division of Medical Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA talking about their featured cover paper in Oncotarget Volume 7 Issue 7 “Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation”

Facebook - http://bit.ly/2xznxjV

Twitter - http://bit.ly/2xzWvsu

LinkedIn - http://bit.ly/2xzJ6kc

Pintrest - http://bit.ly/2xzX8SS

Reddit - http://bit.ly/2hoxI0N

www.Oncotarget.com

Full Text: bit.ly/2xufwZQ

Critically, our findings suggest for the first time that targeting BRAFWT/V600E and CDK4/6 represents a novel therapeutic strategy to treat vemurafenib-resistant or vemurafenib-naïve radioiodine-refractory BRAFWT/V600E-PTC. This combined therapy could prevent selection and expansion of aggressive PTC cell sub-clones with intrinsic resistance, targeting tumor cells either with primary or secondary resistance to BRAFV600E inhibitor.

Facebook - bit.ly/2xznxjV

Twitter - bit.ly/2xzWvsu

LinkedIn - bit.ly/2xzJ6kc

Pintrest - bit.ly/2xzX8SS

Reddit - bit.ly/2hoxI0N

www.Oncotarget.com

Audiopaper - Published in Volume 8 Issue 42 of Oncotarget - "A global comparison of the cost of patented cancer drugs in relation to global differences in wealth" by Daniel A. Goldstein from the Davidoff Cancer Center, Rabin Medical Center, Petach Tikvah, Israel and the Winship Cancer Institute, Emory University, Atlanta, GA, USA

Full text - http://bit.ly/2xBGMsU

Facebook - http://bit.ly/2xznxjV

Twitter - http://bit.ly/2xzWvsu

LinkedIn - http://bit.ly/2xzJ6kc

Pintrest - http://bit.ly/2xzX8SS

Reddit - http://bit.ly/2hoxI0N

www.Oncotarget.com

Sustained autophagy contributes to the metabolic adaptation of cancer cells to hypoxic and acidic microenvironments. Since cells in such environments are resistant to conventional cytotoxic drugs, inhibition of autophagy represents a promising therapeutic strategy in clinical oncology. We previously reported that the efficacy of hydroxychloroquine (HCQ), an autophagy inhibitor under clinical investigation is strongly impaired in acidic tumor environments, due to poor uptake of the drug, a phenomenon widely associated with drug resistance towards many weak bases. In this study we identified salinomycin (SAL) as a potent inhibitor of autophagy and cytotoxic agent effective on several cancer cell lines under conditions of transient and chronic acidosis. Since SAL has been reported to specifically target cancer-stem cells (CSC), we used an established model of breast CSC and CSC derived from breast cancer patients to examine whether this specificity may be associated with autophagy inhibition. We indeed found that CSC-like cells are more sensitive to autophagy inhibition compared to cells not expressing CSC markers. We also report that the ability of SAL to inhibit mammosphere formation from CSC-like cells was dramatically enhanced in acidic conditions. We propose that the development and use of clinically suitable SAL derivatives may result in improved autophagy inhibition in cancer cells and CSC in the acidic tumor microenvironment and lead to clinical benefits.

Full text - http://bit.ly/2m8L2Mk

Facebook - bit.ly/2xznxjV

Twitter - bit.ly/2xzWvsu

LinkedIn - bit.ly/2xzJ6kc

Pintrest - bit.ly/2xzX8SS

Reddit - bit.ly/2hoxI0N

www.Oncotarget.com