After completing the material in this chapter each student should:-

* understand the separate assumptions associated with the one compartment model, rapid IV bolus dosing and linear elimination

* understand the properties of first order kinetics, linear models

* be able to write the differential equations for a simple pharmacokinetic model

* be able to define, use, and calculate the parameters:

* * kel (elimination rate constant)

* * V (apparent volume of distribution)

* * t1/2 (half-life)

* * AUC (area under the concentration versus time curve)

* * Cl (clearance)

as they apply to a one compartment linear model

* be able to use the integrated equations for a one compartment linear model to perform various dose and dosing regminen calculations