Midlife Mayhem

Oral vs Injection vs Cream: The Testosterone Showdown


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Testosterone therapy is exploding in popularity, especially among midlife women — but how you take testosterone dramatically affects how it works in your body.

In this episode, Joanne breaks down the three major delivery systems — transdermal creams, oral lozenges, and injections — and explains why some women are now being told they’re “poor absorbers” and switched to oral or injectable forms.

You’ll learn:

  • Why women may not respond to topical testosterone (and why “poor absorber” is often misdiagnosed)

  • How creams differ from orals in absorption, side effects, and DHT conversion

  • Why oral lozenges feel strong quickly — and the real reason they spike DHT

  • Why injections seem aggressive but actually deliver the smoothest hormonal profile

  • Which delivery system works best depending on your goals, symptoms, and physiology

  • How men differ in absorption and why some men do brilliantly on gels while others might as well bathe in them

  • How dosing, metabolism, and estrogen/testosterone balance influence results

  • How to talk to your provider about choosing the right method

    This episode is a must-listen for any woman navigating midlife hormones — and for men who want to understand why their therapy may or may not be working.

    💉 Delivery Systems Explained

    Joanne breaks down:

    1. Transdermal Creams
    • Gentle, steady, least DHT-converting

    • Great for subtle libido, mood, strength improvements

    • Why absorption varies wildly between women

    • When creams are not enough

      2. Oral Lozenges
      • Fast-acting, potent, and sharp

      • More likely to spike DHT

      • Why these are often a solution for “non-responders” — but come with caveats

      • The classic “love it or hate it” delivery method

        3. Injections
        • The smoothest and most predictable system

        • Lowest DHT spikes compared to oral

        • Best for consistent energy, stable mood, and strong results

        • Why smaller, more frequent microdoses are often ideal for women

          🔥 Who This Episode Is For
          • Women feeling under-dosed or inconsistent on testosterone cream

          • Women newly prescribed oral testosterone and unsure what to expect

          • Anyone concerned about androgenic symptoms like acne, hair shedding, or irritability

          • Men frustrated with gels or creams

          • Anyone navigating TRT/HRT and wanting real science without fear or fluff

            👀 Want More Like This?

            This episode is part of Joanne’s in-depth midlife education series. If you love detailed, physiology-first coaching — not surface-level soundbites — you’ll love what’s coming next.

            🌐 Explore the New Website

            My brand-new website is live (not fully finished, but go have a peek):

            👉 www.joannelee.com

            This is where all upcoming programs, courses, podcasts, and resources will live.

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            Midlife MayhemBy joanne lee cornish