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Oral precancerous lesions are a worldwide health concern requiring public health interventions for prevention of oral cancer. These lesions, like leukoplakia, can progress to malignancy, with risk influenced by factors such as tobacco, alcohol, and HPV. Early detection through screening programs and public education campaigns are crucial strategies for improving outcomes. Technological advancements are enhancing diagnostic capabilities and offering new treatment possibilities, though challenges remain in resource allocation and access to care globally. Ultimately, a coordinated global effort is necessary to reduce the burden of oral cancer stemming from these precancerous conditions.