Dr. Ben Lynch, pioneer in epigenetics and Nutrigenomics and author of Dirty Genes, discusses the profound impact of understanding our genetic blueprint and how personalized strategies can optimize health. He introduces his tool, StrateGene, a comprehensive genetic analysis that enables individuals and practitioners to develop precise health plans based on one's genetic pathways. Dr. Lynch emphasizes the importance of looking beyond mere genetic variations and understanding the epigenetic factors that influence gene expression. This episode explores how a strategic approach to genetics empowers people to work with their DNA rather than being limited by it.

Key Takeaways:

• StrateGene is a strategic tool that maps out genetic pathways, highlighting vulnerabilities and providing actionable strategies for health optimization.
• Traditional genetic reports often oversimplify by suggesting a single supplement or action for each variation, leading to confusion and ineffective treatment.
• Genetics is just the beginning—epigenetics (environmental and lifestyle influences) play a crucial role in how genes express and affect health.
• Dr. Lynch emphasizes the concept of "Dirty Genes," where genes can be "born dirty" (genetic predisposition) or "act dirty" due to lifestyle and environmental factors.
• Understanding one's genetic pathways enables better decisions in nutrition, lifestyle, and supplementation to mitigate health risks and enhance well-being.
• Misguided supplement recommendations based on genetic variations can sometimes worsen health conditions; personalized analysis is crucial.
• Dr. Lynch stresses the importance of patient empowerment through education, enabling them to participate actively in their health journey.
• StrateGene is designed to be a lifelong reference tool for health professionals and individuals, evolving as one’s health journey progresses.
• The difference between genetic predisposition and actual health outcomes is determined largely by lifestyle choices and environmental exposures.

Connect with Dr. Lynch - https://www.drbenlynch.com/

LINKS

https://sequencing.com/

In this episode, we explore Nicole Castellano's remarkable journey from her diverse career as a pilot, world-class skater, and entrepreneur to confronting a mysterious illness that began a 12-year diagnostic odyssey. We discuss the challenges inherent in diagnosing rare conditions like porphyria, the transformative role of genetic testing, and the critical importance of patient advocacy. Nicole, who now serves as the executive director of the American Porphyria Foundation, shares her personal experiences and offers insights into how advanced technologies like whole genome sequencing, combined with increased patient empowerment, can significantly reduce diagnostic timelines and restore hope for individuals living with rare diseases.

What You'll Learn:

• Nicole Castellano's Personal Journey: Her life before porphyria, the onset of her illness, the long diagnostic odyssey (12 years, numerous doctors and misdiagnoses), and her eventual diagnosis and advocacy work.    
• Porphyria: The nature of the disease, its symptoms, the challenges in diagnosis, and the different types (acute hepatic porphyria, cutaneous porphyrias, etc.).    
• The Diagnostic Odyssey: The difficulties and delays in obtaining a correct diagnosis for rare diseases.    
• The Role of Genetic Testing: The importance of genetic and biochemical testing in diagnosing porphyria, the limitations of current testing methods, and the potential of whole genome sequencing.    
• Patient Empowerment and Advocacy: The importance of patients and families advocating for themselves, the role of support groups and online resources, and the need for greater awareness among healthcare professionals.    
• The American Porphyria Foundation (APF): Its role in supporting patients, providing resources, and working to improve diagnosis and treatment.    
• Innovations in Healthcare: The potential of AI and precision medicine to improve diagnosis and treatment of rare diseases.    

https://porphyriafoundation.org/

LINKS

https://sequencing.com/

In this episode of Outsmart Your Genes, Dr. Jeremy Koenig sits down with Dr. Jason Siefferman, a triple board-certified physician specializing in physical medicine, rehabilitation, interventional pain medicine, and headache medicine. As the founder and medical director of Manhattan Pain Medicine, Dr. Siefferman shares his expertise in diagnosing and treating complex pain conditions, particularly in patients with hypermobility spectrum disorders and Ehlers-Danlos Syndrome (EDS). He discusses his unique journey from studying music to medicine, highlighting the parallels between the two disciplines in collaboration and patient care. Dr. Siefferman delves into the challenges of treating chronic pain, the importance of understanding its root causes, and how regenerative medicine, including prolotherapy and platelet-rich plasma (PRP) therapy, is revolutionizing care for hypermobility-related pain. He also explores the role of genetics in precision medicine, the potential of AI in diagnostics, and his vision for advancing research in pain management. Tune in for an insightful discussion on redefining chronic pain treatment and integrating genetic insights into patient care.

What You'll Learn:

• Dr. Jason Siefferman's Expertise – Triple board-certified in physical medicine, rehabilitation, interventional pain medicine, and headache medicine.
• Manhattan Pain Medicine – Multidisciplinary approach to diagnosing and treating complex pain conditions.
• Music & Medicine Connection – How Dr. Siefferman’s background in music influences his patient care approach.
• Challenges in Chronic Pain Treatment – The need to understand the root cause of pain rather than just treating symptoms.
• Hypermobility Spectrum Disorders & EDS – Diagnosis, treatment, and challenges in managing these conditions.
• Regenerative Medicine – Use of prolotherapy and platelet-rich plasma (PRP) to strengthen ligaments and stabilize joints.
• Genetics in Pain Medicine – Role of DNA-driven diagnostics in precision-based treatment models.
• Artificial Intelligence in Healthcare – Potential for AI to enhance diagnostics and research in pain management.
• Future of Pain Management – The need for more clinical studies and standardization of treatment protocols for hypermobility disorders.
• Collaboration in Medicine – Importance of interdisciplinary teamwork in improving patient outcomes.

Connect with Dr. Jason: https://www.linkedin.com/in/jsiefferman/

#Sequencing #WholeGenomeSequencing #WGS #DNATesting #GeneticTesting #GeneTesting #EhlersDanlosSyndrome #EDS #HypermobileEDS #HealthTech #PrecisionMedicine #Genomics #Biotech

LINKS

https://sequencing.com/

In this episode, we welcome Denise Morrow, a trailblazer in patient advocacy whose personal diagnostic odyssey led to groundbreaking health discoveries. After decades of searching for answers, whole genome sequencing enabled her to identify a primary CoQ10 deficiency, dramatically improving her health and inspiring her to launch Genetics for Health. In collaboration with Dr. Karen Erbs, Denise is now on a mission to empower others navigating similar medical mysteries by utilizing genetic insights to uncover root causes of rare diseases. From her early struggles with undiagnosed conditions to her relentless pursuit of answers, Denise shares how genetic data transformed her life and how she’s using her experience to help others regain control over their health. Tune in for an inspiring conversation on the power of genomics, patient advocacy, and the future of precision medicine.

Episode Highlights:

• Denise Morrow’s Diagnostic Odyssey – Her decades-long journey to uncover the root cause of her health struggles.
• Whole Genome Sequencing – How sequencing technology led to her life-changing discovery.
• Primary CoQ10 Deficiency – The key genetic insight that transformed her health.
• Genetics for Health Initiative – Denise’s new venture to help others navigate their genetic data.
• Collaboration with Dr. Karen Erbs – Partnering to bring genetic insights into clinical practice.
• Rare Disease Advocacy – Empowering patients to take control of their health journeys.
• The Role of Sequencing.com – How its tools enabled Denise to decode her genetic story.
• The Future of Precision Medicine – How genetic discoveries are shaping personalized healthcare.

Connect with Denise: https://www.linkedin.com/in/denise-morrow-9594b93/

LINKS

https://sequencing.com/

 In this episode, Dr. Jeremy Koenig sits down with Dr. Brandon Colby, a pioneer in predictive medicine and CEO of Sequencing, to explore how whole genome sequencing is transforming healthcare. Dr. Colby shares his personal journey of living with a rare genetic disease, which fueled his mission to revolutionize disease prevention. They discuss the shift from reactive to proactive medicine, the role of genetic insights in personalized health strategies, and how Sequencing’s cutting-edge tools like NextGen Disease Screen and HealthScan empower individuals to take control of their health. From identifying hidden genetic risks to staying ahead of evolving research, this conversation highlights how DNA knowledge is unlocking new possibilities for longevity and well-being.


Episode Highlights:

• From Diagnosis to Prevention – Dr. Brandon Colby emphasizes the shift from reactive medicine to predictive and preventive healthcare through whole genome sequencing.
• Personal Mission – Dr. Colby’s experience with a rare genetic disease drove him to pioneer solutions that empower individuals with actionable genetic insights.
• Whole Genome vs. Traditional Testing – Unlike traditional genetic tests that analyze a limited number of markers, whole genome sequencing provides a complete view of an individual’s genetic risk factors.
• Actionable Insights – Genetic testing isn’t just about identifying risks—it enables people to make informed lifestyle choices, modify environmental factors, and improve long-term health outcomes.
• NextGen Disease Screen – Sequencing.com’s tool analyzes over 10,000 diseases, offering users a comprehensive look at potential genetic risks in a single report.
• HealthScan for Ongoing Updates – Since genetic research evolves rapidly, HealthScan continuously updates users on new findings relevant to their genome, ensuring they stay ahead of potential health risks.
• Genetic Testing for Families – Whole genome sequencing is becoming an essential tool for parents, helping identify potential health risks in newborns and enabling proactive care from birth.
• The Future of Medicine – With advancements in AI, data analytics, and genetic research, Dr. Colby envisions a future where genome sequencing becomes a standard part of preventive healthcare worldwide.

Connect with Dr. Brandon:

https://www.linkedin.com/in/brandoncolbymd

https://sequencing.com/

LINKS

https://sequencing.com/