Sciences & Technologies

Paclitaxel; Mechanism of action⑦

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How does paclitaxel work to treat cancer?

Which phase of cell cycle does it work in?

(Reference)

  1. Microtubules; The basics Molecular biology of the cell 10, 2309-2327(1999)

    2. https://www.nature.com/scitable/content/microtubules-the-basics-14673338

    2.Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.Jawdat AI Bassam, et al.vol.21 (10)604-614 Oct 2011, Trends in cell biology.

    https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(11)00128-0?code=cell-site

    1. Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures. Elizabeth H Kellogg, et al. Journal of Molecular Biology. 429(5). January 2017

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