This research from Nature Neuroscience explores how the mammalian central nervous system regulates gene expression following injury. By utilizing single-nucleus multiomics, the authors identified thousands of injury-responsive enhancers (IRENs) that control cell-type-specific repair and stress programs in the mouse spinal cord. They developed deep learning models to decode the complex DNA sequence...去小宇宙查看完整单集简介
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This research explores how the Alzheimer’s drug Lecanemab utilizes microglia to eliminate harmful amyloid-beta (Aβ) plaques from the brain. By utilizing human microglia xenograft models and spatial transcriptomics, scientists discovered that the therapy’s effectiveness depends on its Fc fragment to trigger a specific genetic program in immune cells. This program boosts phagocytosis, improves lysos...去小宇宙查看完整单集简介
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This research introduces CCF-ME, a high-resolution mouse brain atlas developed by analyzing the dendritic microenvironments of over 100,000 neurons. Unlike traditional maps based on cell density, this framework groups neurons by integrating the morphological features of their local neighborhoods to reveal a more detailed anatomical organization. This innovative approach nearly doubles the number o...去小宇宙查看完整单集简介
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This research investigates how oxidized phosphatidylcholines (OxPCs) act as primary drivers of chronic neurodegeneration in progressive multiple sclerosis (P-MS). By using a mouse model, the authors demonstrate that depositing these toxic byproducts into the central nervous system creates persistent lesions that mirror the pathological and transcriptomic signatures of human disease. The study high...去小宇宙查看完整单集简介
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This research outlines a complex, brain-wide network called the allostatic–interoceptive system, which is responsible for regulating the body's metabolic resources and interpreting internal signals. By utilizing 7 Tesla fMRI technology, the study provides unprecedented detail regarding the connections between the cerebral cortex and small, deep structures within the brainstem and midbrain. The fin...去小宇宙查看完整单集简介
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This study introduces dendritome mapping, a high-throughput systems biology pipeline designed to profile the complex dendritic morphology of individual neurons in the mouse brain. By utilizing advanced 3D reconstruction and automated registration into a reference atlas, the researchers cataloged over 3,700 striatal medium spiny neurons (MSNs). Their findings reveal that neuronal shape is heavily i...去小宇宙查看完整单集简介
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This research identifies a specific group of leptin-sensitive neurons in the lateral hypothalamus (LepRLH) that helps animals overcome anxiety to perform essential survival behaviors. Using single-cell imaging and circuit manipulation in mice, scientists discovered that these neurons are activated by anxiogenic stimuli, such as open spaces or food in unfamiliar environments, to facilitate explorat...去小宇宙查看完整单集简介
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This study examines how the C9orf72 gene mutation affects the immune response in the central nervous system of patients with amyotrophic lateral sclerosis (ALS). By comparing genetic and sporadic forms of the disease, researchers discovered that the C9orf72 mutation causes haploinsufficiency, which prevents microglia from transitioning into necessary reactive and protective states. Unlike sporadic...去小宇宙查看完整单集简介
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The study introduces CSF-STREAM, a groundbreaking, noninvasive MRI technique designed to map the movement of cerebrospinal fluid at high resolutions. Researchers utilized this method to identify region-specific drivers of fluid mobility, discovering that cardiac cycles dominate movement at the brain’s base while respiration and vasomotion contribute significantly in smaller perivascular channels. ...去小宇宙查看完整单集简介
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This research explores how psychedelic substances like psilocybin decouple the relationship between neuronal activity and blood flow in the brain. Using both human neuroimaging and advanced optical imaging in mice, the authors discovered that these drugs disrupt neurovascular coupling, causing hemodynamic signals, the foundation of fMRI data, to become unreliable indicators of actual brain activit...去小宇宙查看完整单集简介
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