This research introduces a pioneering spatiotranscriptomics platform designed to map the entire molecular and cellular landscape of the laboratory mouse. By combining Array-seq technology with a novel computational algorithm called LABEL, researchers can now simultaneously identify 379 distinct cell types and 16 major organ systems within a single whole-body section. This framework transitions bio...去小宇宙查看完整单集简介
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This article identifies a critical developmental shift in mammalian skin where the ability to achieve organ-level regeneration is lost shortly after birth. While embryonic wounds can fully restore complex structures like hair follicles and sweat glands, postnatal injuries typically result in scarring and a failure to regenerate diverse cell lineages. The study discovers that postnatal wound-specif...去小宇宙查看完整单集简介
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The paper details the MSK-50K cohort, a massive clinico-genomic study analyzing over 54,000 tumors across 448 cancer subtypes to map tissue-specific driver alterations. Researchers identified 164 new cancer hotspots and discovered that one-third of drivers occur in non-canonical contexts, often displaying unique biological features like increased subclonality and later emergence. The study highlig...去小宇宙查看完整单集简介
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This research demonstrates that radiotherapy significantly improves the effectiveness of adeno-associated virus (AAV) gene therapy by triggering epigenetic changes that boost transgene expression. Scientists developed a specialized AAV platform using an interferon-inducible promoter to ensure that therapeutic cytokines, specifically IL-12, are only produced within the irradiated tumor site. This l...去小宇宙查看完整单集简介
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This study provides a comprehensive genomic and immunological analysis of the transition from premalignant dysplastic nodules to very early hepatocellular carcinoma (veHCC). Researchers discovered that while TERT alterations often exist in early lesions, the actual shift to malignancy is primarily driven by the accumulation of copy number alterations (CNAs) rather than single-nucleotide mutations....去小宇宙查看完整单集简介
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This research identifies transforming growth factor β (TGFβ) as a major obstacle to the formation of tertiary lymphoid structures (TLSs) in pancreatic cancer. While lymphotoxin beta receptor (LTBR) signaling can trigger the development of these immune aggregates, high levels of TGFβ program fibroblasts into a myofibroblastic (myCAF) state that suppresses immune cell recruitment. By inhibiting the ...去小宇宙查看完整单集简介
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This study presents a comprehensive, high-resolution atlas of human glioblastoma, documenting the complex cellular and molecular organization within the tumor's distinct anatomical regions. By integrating spatial transcriptomics, single-cell RNA sequencing, and protein measurements, the researchers mapped 56 distinct cell states across more than 115,000 spatial data points. They identified previou...去小宇宙查看完整单集简介
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This research introduces DrugReflector, a deep learning architecture designed to accelerate phenotypic drug discovery by linking disease biology with chemical interventions through transcriptomics. By utilizing a lab-in-the-loop active reinforcement learning framework, the system iteratively refines gene signatures to prioritize compounds likely to induce desired cellular changes. In experimental ...去小宇宙查看完整单集简介
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The paper introduces So3D, the first comprehensive, cross-species online resource dedicated to three-dimensional spatial omics. While previous databases focused on two-dimensional tissue slices, this platform integrates over 70 datasets across four species to reconstruct complex 3D tissue architectures. It features five specialized analysis modules designed to identify spatial domains, map cell ty...去小宇宙查看完整单集简介
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This research describes a large-scale functional study designed to pinpoint the causal genetic variants behind complex human diseases and traits. By utilizing massively parallel reporter assays (MPRA), the authors tested over 200,000 fine-mapped variants across five different cell types to measure their direct impact on gene regulation. They successfully identified 13,121 trait-associated regulato...去小宇宙查看完整单集简介
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