PCR Perspectives

PCR Perspectives

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PCR Perspectives episodes

  • How to understand and manage the large spectrum of shock phenotypes?
    Marko Noc speaks with Holger Thiele at #europcr 2026 about cardiogenic shock and the growing importance of recognising shock phenotypes in clinical practice. What do we really mean by “shock phenotypes”, and how should they shape management decisions? The discussion also addresses the specific challenges of out-of-hospital cardiac arrest, and how underlying pathophysiology adds further complexity to an already heterogeneous patient population. In 2026, what actually works in cardiogenic shock management, and where is the evidence still evolving? The conversation also looks ahead to ongoing and future randomised trials, and whether better phenotyping could help define more homogeneous study populations and ultimately improve outcomes. Finally, they review the key principles of managing patients in cardiogenic shock today, from initial assessment to treatment strategy. A focused discussion on one of the most challenging and rapidly evolving areas in acute cardiovascular care.

    Hosted on Acast. See acast.com/privacy for more information.

    11 min
  • Risk evaluation in asymptomatic patients: what is the current and future role of CT angiography?
    Ronak Rajani speaks with Carlos Collet at #europcr 2026 about the role of coronary CT angiography in cardiovascular risk assessment among asymptomatic individuals. How should cardiovascular risk be evaluated in patients without symptoms, and what do current guidelines recommend? Can coronary CT angiography improve risk stratification beyond traditional clinical risk scores, and which patients are most likely to benefit from imaging? The discussion explores the information provided by coronary CT angiography, from stenosis severity and plaque characteristics to newer approaches such as functional assessment and the evaluation of pericoronary adipose tissue. These emerging technologies may offer additional insights into plaque biology and cardiovascular risk. How do these advances fit within current guidelines, and what does the latest clinical evidence tell us about their potential role in prevention strategies? Listen to this discussion to learn about the current and future role of coronary CT angiography in asymptomatic patients.

    Hosted on Acast. See acast.com/privacy for more information.

    12 min
  • What are the latest developments in TAVI for aortic regurgitation?
    In this #europcr 2026 conversation, Andreas Baumbach speaks with Raj Makkar about one of the most rapidly evolving areas in structural heart interventions: TAVI for aortic regurgitation. While TAVI has become an established treatment for aortic stenosis, managing patients with pure native aortic regurgitation remains more challenging. In recent years, dedicated transcatheter devices have been developed and evaluated, with encouraging results in patients who are at high surgical risk or unsuitable for surgery. The discussion focuses on the ALIGN-AR study, which assessed a dedicated TAVI device in patients with symptomatic, moderate-to-severe or severe aortic regurgitation who were not appropriate candidates for surgery. Andreas Baumbach and Raj Makkar review the study design, patient population, and key outcomes, and discuss how these findings may influence clinical practice. They also explore the current guideline recommendations and the future role of transcatheter therapies in the management of aortic regurgitation. Listen to this insightful discussion to learn about the latest evidence and emerging treatment options for this challenging patient population.

    Hosted on Acast. See acast.com/privacy for more information.

    7 min
  • Why are most unstable coronary lesions missed by angiography?
    In this #europcr 2026 interview, Davide Capodanno and Peter Libby discuss the role of inflammation in atherosclerosis and why many high-risk coronary plaques remain undetected by angiography. Advances in vascular biology have revealed how inflammation contributes to plaque instability and rupture, yet vulnerable plaques may appear angiographically insignificant. How can these lesions be identified before they lead to clinical events? What role do inflammation and emerging therapeutic targets play in reducing residual cardiovascular risk? Listen to this discussion to explore the mechanisms of plaque vulnerability and their implications for coronary artery disease management.

    Hosted on Acast. See acast.com/privacy for more information.

    10 min
  • Who should we consider for tricuspid intervention in 2026?
    Julien Dreyfus and Fabien Praz review the current indications and management of severe tricuspid regurgitation, highlighting that treatment is now recommended for symptomatic patients, and emphasising the importance of early referral before irreversible organ damage occurs. They outline a stepwise, multimodality diagnostic approach performed in expert heart valve centres, combining echocardiography, CT, right heart catheterisation and heart team evaluation to guide decision-making. Recent evidence shows that effective reduction of tricuspid regurgitation, whether through repair or replacement, can improve symptoms and reduce heart failure hospitalisations. The key message is that timely diagnosis, appropriate patient selection, and a tailored strategy are essential to optimise outcomes.

    Hosted on Acast. See acast.com/privacy for more information.

    6 min
  • Perspectives from a neurologist and a cardiologist on LAA closure vs DOAC for stroke prevention
    In this discussion, Lorenz Räber and David Seiffge review the latest evidence on percutaneous left atrial appendage (LAA) closure for stroke prevention, focusing on the CLOSURE AF and CHAMPION AF trials, highlighting that LAA closure provides stroke rates comparable to anticoagulation, with a key advantage in reducing bleeding risk. While a small signal of increased ischaemic stroke warrants further evaluation, the procedure is considered safe and particularly valuable for patients at high bleeding risk or unable to tolerate anticoagulation. Careful patient selection remains essential, with emerging interest in its use for patients experiencing stroke despite anticoagulation.

    Hosted on Acast. See acast.com/privacy for more information.

    13 min
  • How to anticipate a complex left atrial appendage closure intervention?
    In this episode, Xavier Freixa and Nina Wunderlich discuss how to better anticipate challenges in LAA closure. Moving beyond traditional morphology classifications, they highlight the importance of clinically relevant anatomical parameters, procedural factors such as coaxiality, and proper planning to optimise outcomes. They also explore what defines an ideal implant and the key role of operator experience and preparedness in managing complex cases.

    Hosted on Acast. See acast.com/privacy for more information.

    8 min
  • What is the latest in the management of coronary artery disease in TAVI candidates?

    Ole De Backer and Daniel Blackman discuss the management of coronary artery disease in TAVI candidates at #europcr 2026, focusing on whether PCI should be performed before valve implantation or can be safely deferred.


    They review PROTAVI, which supports a more selective strategy with PCI only when clinically indicated, suggesting less bleeding without clear harm from deferral. They contrast this with NOTION-3, which suggests a potential benefit of more systematic revascularisation before TAVI, but with important differences in design and endpoint definitions, particularly the inclusion of revascularisation in the primary outcome.


    Overall, the discussion highlights that there is no universal strategy and that decisions should be individualised based on coronary complexity, ischaemic risk, and bleeding risk.


    They also address a key clinical question often overlooked: how to manage patients with angina symptoms and whether valve treatment should still come first, followed by reassessment of coronary disease after TAVI.


    A practical discussion on a complex and evolving area of TAVI care!

    Hosted on Acast. See acast.com/privacy for more information.

    9 min
  • Reducing radiation exposure in the cath lab: What you need to know

    In this discussion, Angeliki Kolyda and Shareefah Shereef highlight the importance of reducing radiation exposure in the cath lab for both patients and staff. They emphasise the cumulative risks of repeated low-dose exposure and the need to adhere to the ALARA principle: minimising radiation through careful management of time, distance, and shielding.

    They also explore how new technologies, such as advanced shielding systems and real-time dosimeters, can support safer practice by increasing awareness and enabling immediate adjustments during procedures.

    The key message: innovation enhances safety, but it must go hand in hand with strong radiation protection practices and a team-wide commitment.

    Hosted on Acast. See acast.com/privacy for more information.

    4 min
  • What is the role of AI in the cath lab of tomorrow?

    Louis‑Marie Desroche and Joost Daemen explore the growing role of artificial intelligence in interventional cardiology. From risk stratification and CT-based plaque analysis to intracoronary imaging and angiography-derived physiology, AI is already transforming decision-making before and during PCI.

    Looking ahead, they highlight AI’s potential to become a true “co‑pilot” in the cath lab. However, key challenges remain, including the need for large-scale clinical validation and closer collaboration between clinicians, industry, and data experts to fully translate these technologies into improved patient outcomes.

    Hosted on Acast. See acast.com/privacy for more information.

    6 min

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