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By Dr. Kylie Burton & Jessica Briecke
Peptides are revolutionizing modern medicine—but the science can feel overwhelming. That's where we come in.
Join Dr. Kylie Burton, Functional Medicine Practitioner, and Jessica Br
... moreThe podcast currently has 71 episodes available.
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The peptide world is full of hype, half-truths, and confusing acronyms, so we’re slowing down and getting specific about two names that keep showing up: BPC-157 and TB-500. Ready to understand BPC-157 (Body Protection Compound) in plain English and why its headline is tissue repair? Next up is the peptide it's often combined with: TB-500, a thymosin beta 4 fragment. It works with actin inside your cells, helping the “right” cells migrate to the “right” place when your body is trying to recover. Our favorite way to remember this Wolverine Stack and the first peptide Dr. Kylie started is: TB-500 directs traffic, BPC-157 does the road work. From there, we bring it to real life with stories from past guests and our own experiences using this peptide combination: severe shoulder history, chronic illness, fitness recovery, and even the kind of stubborn ankle pain that just won’t budge. Not ready for injections? Dr. Kylie wasn't either. Capsules are available. If you’re curious about the Wolverine Stack (BPC-157 and TB-500)as it helps with recovery, are peptides for tendon and ligament support, and peptides for gut health, tune in. Then share it with your audience so they can benefit from this peptide stack too. BPC-157 and TB-500 are the peptides that'll have you saying "is it possible to feel this good at this age?" Where do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.com Ready to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform at drkylieburton.com/shop. Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com/peptidesaffiliate. You can also get started through Jessica's platform at B2BwithJess.com. Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary. You have the science. You have the tools. Now it's time to take the next step. This is PepTalk: Peptides Unpacked—science made simple, re...

Why do so many patients — not just those with endometriosis — end up cycling through specialists, labs, and prescriptions without ever getting a real answer? In this episode, Dr. Kylie Burton and Jessica Brickie sit down with gynecologist and women's health advocate Dr. Joelle Osias to make the case for a different model of medicine altogether: one built on root causes, individualized labs, and tools like peptides and GLP-1s that fall outside the standard playbook. Dr. Osias uses her own path — from Stanford- and Johns Hopkins-trained gynecologist to outspoken advocate for personalized medicine — to explain why "standard of care" so often means algorithmic, one-size-fits-all treatment, and what changes when a physician is willing to look at the whole body instead of just their assigned specialty. She and the hosts trace that thinking through endometriosis as a case study (its whole-body, autoimmune nature, the limits of hormones and repeat surgery), but the conversation ranges well beyond it — into gut health and food sensitivities, thyroid testing gaps, vitamin D, peptides like BPC-157 and KPV, and the growing off-label use of GLP-1s for inflammation, PCOS, cardiovascular risk, and even cancer prevention. Jessica also shares her own diagnosis story from 1990, grounding the discussion in just how far — and how little — medicine has moved in three decades. Whether or not endometriosis is part of your story, this episode is really about a bigger question: what does it look like to treat the whole patient, and what tools exist for that once you step outside the standard of care? What You'll LearnWhy "standard of care" is often algorithmic by design — and what gets lost when medicine treats patients as a protocol instead of an individualHow Dr. Osias started incorporating peptides (including BPC-157 and KPV) into patient care, and the regulatory hurdles around off-label and non-FDA-indicated treatmentsGLP-1 microdosing for inflammation, PCOS, cardiovascular risk, and more — including why standard pharmaceutical dosing doesn't fit every patientThe gut-immune connection, food sensitivities, and why 80% of the immune system lives in the gutCommonly missed labs: free T3, reverse T3, vitamin D, ferritin — and why standard panels can miss real dysfunctionThe challenges of accessing peptide and GLP-1 therapy for adolescent patientsEndometriosis as a case study: what it actually is, why it's better understood as a whole-body autoimmune-inflammatory condition, and why surgery and hormones alone so often fall shortThe risks of early hysterectomy and why Dr. Osias considers it a last resort, not a first-line fixWhy Dr. Osias believes personalized medicine, not algorithmic standard-of-care protocols, is the future of healthcare — for women and men alike Segment BreakdownWhat Endometriosis Really Is — Redefining endometriosis as a whole-body, autoimmune-inflammatory conditionGenetics, Toxins & Immune Clues — Family patterns, environmental exposures, and immune dysfunctionWhy Surgery Alone Falls Short — The limits of the "medicate and operate" cycleStandard of Care & the Patient Runaround — How patients get bounced between specialists without answersLearning Peptides Beyond the Rules — Dr. Osias's journey into BPC-157, patient-driven discovery, and the FDA approval processGLP-1 Microdosing for Inflammation — Off-label use, dosing challenges, and stigma around GLP-1 therapyGut, Thyroid, Vitamin D & Root Causes — The labs conventional care often skipsPeptides for Teens: Safety & Access — Navigating age restrictions and adolescent carePersonalized Care & Patient Agency — Why patients need to be partners, not passengers, in their own treatment Guest Dr. Joelle Osias is a gynecologist, entrepreneur, and women's health advocate based in Menlo Park, California. She trained at Tufts University and Stanford University School of Medicine, completed her residency at Johns Hopkins, and pursued advanced training through the Royal College of Obstetricians and Gynecologists and Stanford Graduate School of Business. Her practice focuses on endometriosis, menopausal care, weight management, and personalized, longevity-focused medicine. Learn more: https://foreviva.com/ Where do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.com Ready to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform at drkylieburton.com/shop. Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com/peptidesaffiliate. You can also get started through Jessica's platform at B2BwithJess.com. Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary. You have the science. You have the tools. Now it's time to take the next step. This is PepTalk: Peptides Unpacked—science made simple, re...

Most people are told to “fix their hormones” when intimacy stops feeling easy, but the body tells a more interesting story: blood flow and stress often sit at the root of desire, arousal, lubrication, and climax. In this episode, we unpack the surprising stats, the early warning signs hidden in sexual dysfunction, and the practical ways to support both the brain’s signal and the body’s response for men and women. We break down why erectile dysfunction can be an early marker of vascular issues, how stress tightens the valve on pleasure, and why so many women are misdirected away from circulation and toward hormone tweaks that don’t move the needle. Then we get specific about tools: how PT-141 influences central arousal, why tadalafil helps vessels stay relaxed to boost sensitivity and performance, and where oxytocin fits as the “connection” cue that eases anxiety and helps you feel safe and present. Expect candid stories, clear science, and zero shame. Whether you’re navigating perimenopause, dealing with inconsistent erections, or just battling a stress-heavy life that leaves no space for closeness, this conversation offers an actionable path: support circulation, calm the nervous system, and align desire with response. Order your ELATE and be one of the first 5,000 (starting February 4th) to do so for a free gift. Order it here: Did Jess send you here? Grab it from her at b2bwithjess.com/peptides Anybody else, grab it (and all other peptides we discuss) at drkylieburton.com/peptidesPlease show the podcast some extra love this month too. If you've been enjoying it, we would love a written review, subscribe, and a social media share. It's greatly appreciated! Where do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.com Ready to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform at drkylieburton.com/shop. Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com/peptidesaffiliate. You can also get started through Jessica's platform at B2BwithJess.com. Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary. You have the science. You have the tools. Now it's time to take the next step. This is PepTalk: Peptides Unpacked—science made simple, re...

In early July, the FDA held a major hearing near Washington, DC, addressing the regulatory status of a group of compounded peptides — and Jessica was there. In this episode, Dr. Kylie Burton and Jessica Briecke break down what actually happened at the hearing (as opposed to the wave of secondhand opinions that circulated online afterward). And shocker, we were the ONLY company who showed up! And we showed up in full force. So what happened and what did the FDA hearing mean to the peptide industry? Jessica explains as she was there. Jessica explains the regulatory shift at the center of the issue: twelve peptides were reclassified from a "Category 1" to "Category 2" status for compounding pharmacies, a change that significantly limits legal access. The hosts argue that restricting supply doesn't reduce demand — it pushes people toward unregulated "gray market" and research-chemical sites, where testing has reportedly turned up contaminants like arsenic and lead, and in some cases, no actual peptide at all in the product. They also talk about the risks of at-home reconstitution using instructions found on social media or generated by AI, done without pharmacist training or a sterile environment. The episode closes with a recap of the advocacy work itself — testimony at the hearing, meetings with congressional offices, and a broader case for regulation (not elimination) of compounded peptides — plus an invitation to a live business information session for anyone interested in partnering with the hosts' telemedicine company. What You'll LearnWhat changed: twelve peptides were moved from Category 1 to Category 2 status for compounding pharmacies, restricting legal accessWhy the hosts argue that restricting legal, regulated supply pushes demand toward the gray/black market instead of eliminating itWhat third-party testing has reportedly found in unregulated "research-grade" peptide powders — including contaminants and products containing no actual peptideThe risks of at-home reconstitution using unofficial instructions, without pharmacist training or a sterile environmentThe distinction the hosts draw between eliminating access and pushing for regulation, medical oversight, and domestic manufacturing standardsA firsthand account of the hearing itself, including testimony from the company's CEO and returning guest Dr. Joelle OsiasHave you been thinking about joining us as a affiliate? Come join us on September 22nd for a LIVE zoom session to learn more and get started. Register and get the details here: drkylieburton.com/register You can also always connect withConnect With UsJessica Brickie: Instagram @jessb.talkshealth | b2bwithjess.comDr. Kylie Burton: drkylieburton.com | Amplify ProgramWhere do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.com Ready to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform at drkylieburton.com/shop. Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com/peptidesaffiliate. You can also get started through Jessica's platform at B2BwithJess.com. Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary. You have the science. You have the tools. Now it's time to take the next step. This is PepTalk: Peptides Unpacked—science made simple, re...

Sermorelin has a half-life of just 10 to 12 minutes — so how does something that leaves your system that fast do anything at all? That's the question Dr. Kylie Burton and Jessica Brickie open with in this episode, using it as the jumping-off point for a side-by-side look at two related growth hormone peptides: sermorelin and tesamorelin. The hosts explain sermorelin's core mechanism — a "gentle nudge" to the pituitary gland that prompts the body to release its own growth hormone in its natural pulsing rhythm, rather than forcing a large spike. They contrast that with tesamorelin, the more potent, FDA-approved (for HIV-associated lipodystrophy) option that's more targeted toward visceral fat. Both are used off-label in adult wellness for goals well beyond their approved indications, and the hosts are upfront about that distinction throughout. From there, the conversation moves into what people actually notice when starting sermorelin — deeper, more restorative sleep; a general sense of vitality; and steadier energy without the afternoon crash — along with an honest look at what's well-established research versus what's still associated/anecdotal. The hosts also spend meaningful time on one of their favorite applications: perimenopausal and postmenopausal women, where growth hormone decline compounds with the broader hormonal shifts of menopause, affecting sleep, energy, recovery, and bone density. What You'll LearnWhy sermorelin's short half-life is the point, not a limitation — it restores a natural release rhythm instead of forcing a spikeThe mechanism behind sermorelin: mimicking GHRH to stimulate the pituitary gland's own growth hormone releaseSermorelin vs. tesamorelin, side by side: potency, FDA-approved indications, off-label adult use, side effect profile, and costWhy tesamorelin is often thought of as the sharper, more targeted tool (visceral fat), while sermorelin functions more like a daily foundationThe three things people notice first: deeper sleep, overall vitality, and steadier energyHow sermorelin's energy mechanism differs from other options like MOT-C or NAD+ — and why it might be worth trying if those haven't worked for youWhat's backed by solid mechanistic research versus what's associated/anecdotal — and why this is a conversation to have with your own providerWhy sermorelin is often described as a good "front door" peptide for people new to peptide therapy or nervous about starting with something strongerWhy growth hormone decline hits an extra inflection point during the menopause transition — and how that ties into sleep, energy, recovery, and bone density for women in perimenopause and postmenopause Segment BreakdownThe 12-Minute Half-Life Mystery — Why sermorelin's fast clearance is actually the mechanism, not a flawGentle Nudge Versus Big Push — How sermorelin restores natural GH pulsing rather than forcing a spikeSermorelin Versus Tesamorelin — FDA-approved indications, off-label use, potency, and cost comparisonWhat People Notice First — Sleep, vitality, and energy as the three most common reported effectsWhat We Know and Don't — Separating established mechanism from anecdotal, individual-level outcomesMenopause, Bone Density, Recovery — Why this life stage is one of the hosts' favorite applications for sermorelinMedical Oversight and Where to Find Us — Why provider oversight matters and where to connect with the hostsWhere do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.com Ready to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform at drkylieburton.com/shop. Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com/peptidesaffiliate. You can also get started through Jessica's platform at B2BwithJess.com. Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary. You have the science. You have the tools. Now it's time to take the next step. This is PepTalk: Peptides Unpacked—science made simple, re...
The podcast currently has 71 episodes available.