GLP-1 medications are the most talked-about compounds in modern medicine — and the most misunderstood. Most of the conversation focuses on weight loss results. Almost none of it explains the biology driving those results.

In this episode of Peptides Explained, we break down the science behind three of the most prescribed GLP-1 compounds: semaglutide, tirzepatide, and retatrutide.

Topics covered include:

• What GLP-1 is and why it matters for metabolic regulation
• How semaglutide mimics a naturally occurring gut hormone to suppress appetite and regulate blood sugar
• What makes tirzepatide different — and why its dual-receptor action changes the clinical picture
• Where retatrutide fits as a triple-agonist and what the early data suggests
• How these medications interact with insulin secretion, gastric emptying, and satiety signaling
• Side effects, clinical context, and what the research actually supports

Whether you're a clinician, a patient, or just someone trying to understand what these medications are actually doing in the body — this episode gives you the mechanistic foundation the headlines leave out.

Disclaimer: This podcast is for informational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional before considering any therapy.

Peptides are everywhere in the health and longevity conversation right now — but most of what's out there skips the fundamentals. Before you can understand semaglutide, BPC-157, or any other compound making headlines, you need to understand what a peptide actually is at the biological level.

In this episode of Peptides Explained, we lay the foundation:

• What peptides are and how they differ from proteins and small molecules
• How peptides function as signaling molecules in the body
• Why the body's own peptide systems are the basis for modern therapeutic compounds
• The difference between endogenous peptides and synthetic or compounded versions
• Why understanding mechanism matters before evaluating any peptide claim

This is the episode to send someone who's heard about peptides but doesn't know where to start. No hype, no bro science — just the biology you need to make sense of everything that comes after.

Disclaimer: This podcast is for informational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional before considering any therapy.