Peptides Explained

Peptides Explained

By John Garrett

Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more.
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Best of Peptides Explained

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  1. Number 1: Should You Be Using Peptides? The Honest Answer

    Visit Peptide-Solutions.info for more info Check out App.PeptidesExplained.info Should you be using peptides? The honest answer is that not everyone should. Peptides are not a nutritional requirement, a shortcut to better health, or something you need simply because they are trending. But some people do have a defined problem—such as obesity, metabolic disease, an injury, loss of function, a diagnosed hormone-related condition, or another health issue—for which a peptide-based medication or investigational compound may be relevant. In this episode, John Garrett, explains how to decide whether a peptide belongs in the conversation. You will learn how to start with the problem rather than the product, compare FDA-approved, off-label, compounded, experimental, and research-use categories, evaluate human versus animal versus anecdotal evidence, identify better-established alternatives, and build a plan for monitoring and stopping. This episode also points viewers to "The 11 Peptides I Find Most Compelling" and the individual Peptides Explained deep dives for compound-specific education. This content is educational only and is not medical advice. Speak with a qualified healthcare professional before starting, stopping, or changing any therapy.

    19min
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  2. Number 2: GHK-Cu Explained: The Science Behind the Copper Peptide for Skin, Hair, and Healing

    GHK-Cu Explained: The Science Behind the Copper Peptide for Skin, Hair, and Healing

    13min
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  3. Number 3: The 11 Peptides I Find Most Compelling

    After researching peptide science week after week—and using some compounds personally—I'm answering one of the most common questions I receive: Which peptides do I find the most useful and compelling? This is not a universal ranking or a recommendation to use all 11. Tirzepatide, retatrutide, tesamorelin, ipamorelin, BPC-157, TB-500, GHK-Cu, KPV, PT-141, MOTS-c, and SS-31 occupy very different evidence and regulatory categories. Some are FDA-approved prescription drugs. Some have encouraging human data. Others remain experimental and are supported mainly by animal, cell, mechanistic, or anecdotal evidence. In this episode, we examine the problem each peptide is intended to solve, how it works, what the human evidence shows, where the evidence is weak, known risks, regulatory status, and why each compound made my personal list. This episode is for education and discussion only. It is not medical advice. Always involve a qualified healthcare professional before starting, stopping, or changing a therapy. Peptides Explained is an affiliate partner with OfflinePeptides.com. Visit PeptidesExplained.info/OfflinePeptides. For Peptides through a compounding pharmacy or a telehealth option Visit Peptide-Solutions.info and submit a request for more information.

    49min
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  4. Number 4: What Are Peptides? The Building Blocks Behind Modern Therapeutic Compounds

    Peptides are everywhere in the health and longevity conversation right now — but most of what's out there skips the fundamentals. Before you can understand semaglutide, BPC-157, or any other compound making headlines, you need to understand what a peptide actually is at the biological level. In this episode of Peptides Explained, we lay the foundation: What peptides are and how they differ from proteins and small molecules How peptides function as signaling molecules in the body Why the body's own peptide systems are the basis for modern therapeutic compounds The difference between endogenous peptides and synthetic or compounded versions Why understanding mechanism matters before evaluating any peptide claim This is the episode to send someone who's heard about peptides but doesn't know where to start. No hype, no bro science — just the biology you need to make sense of everything that comes after. Disclaimer: This podcast is for informational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional before considering any therapy.

    19min
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  5. Number 5: Did Your GLP-1 Stop Working? Appetite, Receptors and Weight-Loss Plateaus

    Peptide-solutions.info App.peptidesexplained.info Does a weight-loss plateau mean your GLP-1 receptors have become desensitized? John separates cellular receptor biology from whole-body weight regulation and compares semaglutide, tirzepatide, and investigational retatrutide. We examine appetite suppression, food noise, gastric-emptying tachyphylaxis, metabolic adaptation, switching therapies, and what the clinical evidence can—and cannot—tell us. A plateau is real. “Receptor burnout” is a much bigger claim. Educational only; not medical advice.

    22min
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How many episodes does Peptides Explained have?

The podcast currently has 53 episodes available.