In this episode Dr. Imran Ahson and Dr. Pamela Yelick discuss the intersection of genetics and dentistry, focusing on translational research and regenerative medicine in oral health. They delve into the importance of genetics in dentistry, highlighting the potential for dentists to identify and study genetically inherited craniofacial features and anomalies. Dr. Yelick also discusses her work in tissue regeneration, particularly in growing dental pulp tissue and developing bioengineered teeth. They touch upon the growing recognition of the oral cavity's importance in systemic health and the need for more funding and support for dental research. Lastly, they emphasize the various career paths available in dentistry beyond private practice, including academia, research, and entrepreneurship.
Dr. Yelick discusses the potential establishment of a DMD PhD program to retain students and emphasizes the increasing interest in research among undergraduates and high school students. She highlights the importance of collaboration between academia and biotech companies to enhance infrastructure and training opportunities.
Throughout the conversation, Dr. Ahson expresses fascination with genetic contributions to tooth and jaw growth, as well as advancements in regenerative medicine. Both experts discuss the potential of stem cells in tooth regeneration, the challenges of cryopreservation for dental pulp stem cells, and the future prospects of gene therapy in treating craniofacial disorders.
Dr. Yelick emphasizes the significance of clinical feedback in product development for regenerative therapies and suggests avenues for clinicians to engage in research, such as contributing to online journals and collaborating with dental materials companies. Dr. Ahson encourages clinicians to explore research opportunities and highlights the accessibility of open-access journals for interdisciplinary dialogue.
Topics:
00:01:00 - Dr. Yelick's background in developmental molecular biology and her transition to studying craniofacial development00:02:00 - Introduction to the zebrafish model and its application in Dr. Yelick's research00:05:00 - Collaboration with Dr. Joseph Vicanti and the inception of research on tooth regeneration00:08:00 - Importance of translational research in dentistry and its impact on clinical practice00:09:00 - Collaboration with Dr. Louise Bertassoni and research on dental pulp stem cells00:12:00 - Potential applications of saliva diagnostics in oral health monitoring00:13:00 - Discussion on the significance of oral health in overall systemic health00:14:00 - Funding challenges and the need for protected time for clinicians pursuing research careers00:16:00 - Collaboration between clinicians and basic scientists in advancing dental research00:19:00 - Dr. Yelick's experience chairing the Gordon Research Conference on craniofacial morphogenesis and tissue regeneration00:22:00 - Challenges faced by clinicians balancing clinical practice and research pursuits00:23:00 - Exploration of diverse career paths available to dental professionals beyond clinical practice00:25:00 - Increasing interest in research among students00:29:00 - Stem cells in tooth regeneration00:39:00 - Challenges of cryopreservation for dental pulp stem cells 00:42:00 - Future prospects of gene therapy for craniofacial disorders Significance of clinical feedback in product development00:51:00 - Opportunities for clinicians to engage in research00:52:00 - Accessibility of open-access journals for